(Q35871790)

English

Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).

scientific article published on 17 December 2015

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scholarly article

1 reference

Europe PubMed Central

10 August 2017

Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7). (English)

1 reference

Europe PubMed Central

10 August 2017

O-linked N-acetylglucosamine (GlcNAc) transferase

1 reference

GOA release 2020-03-11

Ubiquitin specific peptidase 7

1 reference

GOA release 2020-03-11

Lysine methyltransferase 2E (inactive)

1 reference

GOA release 2020-03-11

thiol-dependent deubiquitinase

1 reference

GOA release 2020-03-11

author name string

Xiaodan Ding

1

1 reference

Europe PubMed Central

10 August 2017

Wei Jiang

2

1 reference

Europe PubMed Central

10 August 2017

Peipei Zhou

3

1 reference

Europe PubMed Central

10 August 2017

Lulu Liu

4

1 reference

Europe PubMed Central

10 August 2017

Xiaoling Wan

5

1 reference

Europe PubMed Central

10 August 2017

Xiujie Yuan

6

1 reference

Europe PubMed Central

10 August 2017

Xizi Wang

7

1 reference

Europe PubMed Central

10 August 2017

Miao Chen

8

1 reference

Europe PubMed Central

10 August 2017

Jun Chen

9

1 reference

Europe PubMed Central

10 August 2017

Jing Yang

10

1 reference

Europe PubMed Central

10 August 2017

Chao Kong

11

1 reference

Europe PubMed Central

10 August 2017

Bin Li

12

1 reference

Europe PubMed Central

10 August 2017

Chao Peng

13

1 reference

Europe PubMed Central

10 August 2017

Catherine C L Wong

14

1 reference

Europe PubMed Central

10 August 2017

Fajian Hou

15

1 reference

Europe PubMed Central

10 August 2017

Yan Zhang

16

1 reference

Europe PubMed Central

10 August 2017

language of work or name

0 references

publication date

17 December 2015

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

10

1 reference

Europe PubMed Central

10 August 2017

12

1 reference

Europe PubMed Central

10 August 2017

e0145023

1 reference

Europe PubMed Central

10 August 2017

copyright license

Creative Commons Attribution 4.0 International

17 December 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Annexin-1 regulated by HAUSP is essential for UV-induced damage response

1 reference

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Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis

1 reference

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27 July 2018

USP7 modulates UV-induced PCNA monoubiquitination by regulating DNA polymerase eta stability

1 reference

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De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder

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27 July 2018

O-GlcNAc transferase and O-GlcNAcase: achieving target substrate specificity

1 reference

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27 July 2018

Ubiquitin-specific protease 7 regulates nucleotide excision repair through deubiquitinating XPC protein and preventing XPC protein from undergoing ultraviolet light-induced and VCP/p97 protein-regulated proteolysis

1 reference

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27 July 2018

Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia.

1 reference

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27 July 2018

Altering O-linked β-N-acetylglucosamine cycling disrupts mitochondrial function

1 reference

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Decreased O-linked GlcNAcylation protects from cytotoxicity mediated by huntingtin exon1 protein fragment

1 reference

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27 July 2018

HCF-1 Is Cleaved in the Active Site of O-GlcNAc Transferase

1 reference

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27 July 2018

O-GlcNAcylation of cofilin promotes breast cancer cell invasion

1 reference

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27 July 2018

A Role for USP7 in DNA Replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

O-GlcNAcylation involvement in high glucose-induced cardiac hypertrophy via ERK1/2 and cyclin D2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

O-linked N-acetylglucosamine transferase (OGT) is overexpressed and promotes O-linked protein glycosylation in esophageal squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

A correlation between altered O-GlcNAcylation, migration and with changes in E-cadherin levels in ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

O-GlcNAc processing enzymes: catalytic mechanisms, substrate specificity, and enzyme regulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

The role of UBL domains in ubiquitin-specific proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

The ubiquitin code

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

O-GlcNAcase is essential for embryonic development and maintenance of genomic stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Critical role of O-Linked β-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

GlcNAcylation of histone H2B facilitates its monoubiquitination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Trithorax group proteins: switching genes on and keeping them active

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Mll5 is required for normal spermatogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

The first identification of lysine malonylation substrates and its regulatory enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Polycomb repressive complex 2 is necessary for the normal site-specific O-GlcNAc distribution in mouse embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

The multifaceted roles of USP7: new therapeutic opportunities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Structure of human O-GlcNAc transferase and its complex with a peptide substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

USP7/HAUSP stimulates repair of oxidative DNA lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Regulation of the Polycomb protein RING1B ubiquitination by USP7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

O-GlcNAc cycling enzymes associate with the translational machinery and modify core ribosomal proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

MLL5 contributes to hematopoietic stem cell fitness and homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

HAUSP as a therapeutic target for hematopoietic tumors (review).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

The hexosamine signaling pathway: deciphering the "O-GlcNAc code"

1 reference

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27 July 2018

Tumour suppression: disruption of HAUSP gene stabilizes p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

A dynamic role of HAUSP in the p53-Mdm2 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

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DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

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MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

27 July 2018

mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

24 September 2018

Cancer metabolism and elevated O-GlcNAc in oncogenic signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

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Gene and protein expression of O-GlcNAc-cycling enzymes in human laryngeal cancer

1 reference

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24 September 2018

MLL5 expression as a biomarker for DNA hypermethylation and sensitivity to epigenetic therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

24 September 2018

Usp7 protects genomic stability by regulating Bub3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

24 September 2018

O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

24 September 2018

O-GlcNAc profiling: from proteins to proteomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

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1 reference

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24 September 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683056

24 September 2018

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1 reference

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1 reference

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1 reference

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24 September 2018

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1 reference

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1 reference

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1 reference

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24 September 2018

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

1 reference

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24 September 2018

Mll2 controls cardiac lineage differentiation of mouse embryonic stem cells by promoting H3K4me3 deposition at cardiac-specific genes

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26678539

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0145023

1 reference

Europe PubMed Central

10 August 2017

2015PLoSO..1045023D

0 references

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

ResearchGate publication ID

0 references

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