(Q35872321)

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MEK1/2 inhibitor selumetinib (AZD6244) inhibits growth of ovarian clear cell carcinoma in a PEA-15-dependent manner in a mouse xenograft model

scientific article published on 5 December 2011

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17 January 2020

MEK1/2 inhibitor selumetinib (AZD6244) inhibits growth of ovarian clear cell carcinoma in a PEA-15-dependent manner in a mouse xenograft model (English)

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17 January 2020

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clear cell carcinoma

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Francisco J Esteva

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17 January 2020

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Junzo Kigawa

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17 January 2020

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Tetsuro Oishi

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17 January 2020

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Chandra Bartholomeusz

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17 January 2020

Hitomi Saso

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17 January 2020

Ugur Akar

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17 January 2020

Ping Liu

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17 January 2020

Kimie Kondo

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17 January 2020

Anna Kazansky

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17 January 2020

Savitri Krishnamurthy

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17 January 2020

Jangsoon Lee

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17 January 2020

Naoto T Ueno

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17 January 2020

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5 December 2011

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17 January 2020

Molecular Cancer Therapeutics

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17 January 2020

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17 January 2020

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17 January 2020

360-369

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17 January 2020

A phase II study of PD-0325901, an oral MEK inhibitor, in previously treated patients with advanced non-small cell lung cancer

1 reference

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Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma

1 reference

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11 July 2018

PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival

1 reference

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Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors

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Activity of lapatinib is independent of EGFR expression level in HER2-overexpressing breast cancer cells

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The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells

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11 July 2018

Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

1 reference

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Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer

1 reference

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11 July 2018

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

1 reference

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11 July 2018

ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320047

11 July 2018

AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in precl

1 reference

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Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt.

1 reference

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11 July 2018

Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor

1 reference

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11 July 2018

Novel combinations based on epidermal growth factor receptor inhibition

1 reference

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11 July 2018

Activating mutations and/or expression levels of tyrosine kinase receptors GRB7, RAS, and BRAF in testicular germ cell tumors

1 reference

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11 July 2018

Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15.

1 reference

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11 July 2018

PED mediates AKT-dependent chemoresistance in human breast cancer cells

1 reference

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11 July 2018

Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation

1 reference

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11 July 2018

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

1 reference

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11 July 2018

RSK2 activity is regulated by its interaction with PEA-15

1 reference

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11 July 2018

Selective inhibition of the epidermal growth factor receptor by ZD1839 decreases the growth and invasion of ovarian clear cell adenocarcinoma cells.

1 reference

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11 July 2018

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

1 reference

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Clinical characteristics of clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy

1 reference

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World Health Organization classification and nomenclature of ovarian cancer

1 reference

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24 September 2018

Efficacy and safety of erlotinib HCl, an epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: results from a phase II multicenter study

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24 September 2018

The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity.

1 reference

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1 reference

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Ovarian clear cell adenocarcinoma

1 reference

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24 September 2018

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10.1158/1535-7163.MCT-11-0400

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17 January 2020

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17 January 2020

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17 January 2020

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