(Q35875920)

English

The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice

scientific article published in March 2012

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scholarly article

1 reference

Europe PubMed Central

10 August 2017

The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice (English)

1 reference

Europe PubMed Central

10 August 2017

Alzheimer's disease

0 references

1 reference

based on heuristic

inferred from title

1 reference

ChEBI release 2020-05-28

toxic encephalopathy

1 reference

based on heuristic

inferred from title

John Q. Trojanowski

3

object named as

John Q Trojanowski

1 reference

Europe PubMed Central

10 August 2017

author name string

Bin Zhang

1

1 reference

Europe PubMed Central

10 August 2017

Jenna Carroll

2

1 reference

Europe PubMed Central

10 August 2017

Yuemang Yao

4

1 reference

Europe PubMed Central

10 August 2017

Michiyo Iba

5

1 reference

Europe PubMed Central

10 August 2017

Justin S Potuzak

6

1 reference

Europe PubMed Central

10 August 2017

Anne-Marie L Hogan

7

1 reference

Europe PubMed Central

10 August 2017

Sharon X Xie

8

1 reference

Europe PubMed Central

10 August 2017

Carlo Ballatore

9

1 reference

Europe PubMed Central

10 August 2017

Amos B Smith

10

1 reference

Europe PubMed Central

10 August 2017

Virginia M-Y Lee

11

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Europe PubMed Central

10 August 2017

Kurt R Brunden

12

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10 August 2017

language of work or name

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publication date

1 March 2012

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10 August 2017

Journal of Neuroscience

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Europe PubMed Central

10 August 2017

32

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Europe PubMed Central

10 August 2017

3601-3611

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Europe PubMed Central

10 August 2017

11

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Europe PubMed Central

10 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3321513/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice

1 reference

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The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies

1 reference

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27 July 2018

Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy

1 reference

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Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies

1 reference

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A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model

1 reference

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1 reference

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Taxanes: optimizing adjuvant chemotherapy for early-stage breast cancer

1 reference

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Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

1 reference

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Novel microtubule-targeting agents - the epothilones.

1 reference

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Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening

1 reference

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Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects.

1 reference

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Discovery of ixabepilone.

1 reference

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Differential regulation of dynein and kinesin motor proteins by tau

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Targeting the microtubules in breast cancer beyond taxanes: the epothilones

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Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

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Multiple-motor based transport and its regulation by Tau.

1 reference

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Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

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Mutations causing neurodegenerative tauopathies

1 reference

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Discovery of (E)-9,10-dehydroepothilones through chemical synthesis: on the emergence of 26-trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B as a promising anticancer drug candidate

1 reference

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Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation

1 reference

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Repeat motifs of tau bind to the insides of microtubules in the absence of taxol

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Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

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Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

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Neurodegenerative tauopathies

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Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

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Tubulin synthesis and assembly in differentiating neurons

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Identifiers

10.1523/JNEUROSCI.4922-11.2012

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

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