(Q35879488)

10 August 2017

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title

14-3-3 Proteins--a focus on cancer and human disease (English)

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10 August 2017

Erik Wilker

1

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10 August 2017

Michael B Yaffe

series ordinal

2

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10 August 2017

language of work or name

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1 September 2004

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Journal of Molecular and Cellular Cardiology

10 August 2017

published in

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10 August 2017

volume

37

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10 August 2017

issue

3

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10 August 2017

page(s)

633-642

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Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

10 August 2017

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Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

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Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

7 January 2021

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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

7 January 2021

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Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.

7 January 2021

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PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells

7 January 2021

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High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer

7 January 2021

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Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth

7 January 2021

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14-3-3 proteins: biological function and domain structure

7 January 2021

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14-3-3 proteins: structure, function, and regulation

7 January 2021

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14-3-3 proteins; bringing new definitions to scaffolding

7 January 2021

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The 14-3-3 proteins: cellular regulators of plant metabolism

7 January 2021

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The structural basis for 14-3-3:phosphopeptide binding specificity

7 January 2021

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14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking

7 January 2021

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Crystal structure of the zeta isoform of the 14-3-3 protein

7 January 2021

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Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways

7 January 2021

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Molecular evolution of the 14-3-3 protein family

7 January 2021

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How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis

7 January 2021

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14-3-3 alpha and delta are the phosphorylated forms of raf-activating 14-3-3 beta and zeta. In vivo stoichiometric phosphorylation in brain at a Ser-Pro-Glu-Lys MOTIF

7 January 2021

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14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction

7 January 2021

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A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein

7 January 2021

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Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding

7 January 2021

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The signal modulator protein 14-3-3 is a target of sphingosine- or N,N-dimethylsphingosine-dependent kinase in 3T3(A31) cells

7 January 2021

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14-3-3zeta C-terminal stretch changes its conformation upon ligand binding and phosphorylation at Thr232.

7 January 2021

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Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding

7 January 2021

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Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variants

7 January 2021

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A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

7 January 2021

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Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation

7 January 2021

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Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Positive regulation of Wee1 by Chk1 and 14-3-3 proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3 proteins: regulation of subcellular localization by molecular interference

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Identification of genes overexpressed in head and neck squamous cell carcinoma using a combination of complementary DNA subtraction and microarray analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Coincident inactivation of 14-3-3sigma and p16INK4a is an early event in vulval squamous neoplasia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3σ Positively Regulates p53 and Suppresses Tumor Growth

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Functional regulation of p73 and p63: development and cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

p63 and p73 transactivate differentiation gene promoters in human keratinocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Role of the beta isoform of 14-3-3 proteins in cellular proliferation and oncogenic transformation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Forced expression of antisense 14-3-3beta RNA suppresses tumor cell growth in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Mutations of the BRAF gene in human cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Disruption of the 14-3-3 binding site within the B-Raf kinase domain uncouples catalytic activity from PC12 cell differentiation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

A novel rap1/B-Raf/14-3-3 theta protein complex is formed in vivo during the morphogenetic differentiation of postmeiotic male germ cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Interaction of the protein kinase Raf-1 with 14-3-3 proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Activation of Raf-1 by 14-3-3 proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Regulation of the Raf-1 kinase domain by phosphorylation and 14-3-3 association.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Interactions of c-Raf-1 with phosphatidylserine and 14-3-3.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3 Isotypes facilitate coupling of protein kinase C-ζ to Raf-1: negative regulation by 14-3-3 phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Regulating mammalian checkpoints through Cdc25 inactivation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

7 January 2021

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Cdc25B activity is regulated by 14-3-3.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Involvement of a type 1 protein phosphatase encoded by bws1+ in fission yeast mitotic control.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Phosphorylation and inactivation of the mitotic inhibitor Wee1 by the nim1/cdr1 kinase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Dual phosphorylation controls Cdc25 phosphatases and mitotic entry

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Rapid destruction of human Cdc25A in response to DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Cell migration: integrating signals from front to back

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Integrins in regulation of tissue development and function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Axis of evil: molecular mechanisms of cancer metastasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Identification of a novel interaction between integrin beta1 and 14-3-3beta

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Lissencephaly and the molecular basis of neuronal migration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3 proteins in the nervous system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3zeta is an effector of tau protein phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

14-3-3 proteins block apoptosis and differentially regulate MAPK cascades

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.015

10.1016/J.YJMCC.2004.04.015

7 January 2021

Identifiers

DOI

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10 August 2017

1 reference