(Q35895234)

English

Tying the knot: the cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines.

scientific article published on 7 October 2011

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scholarly article

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12 February 2020

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12 September 2020

Tying the knot: the cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines (English)

1 reference

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12 February 2020

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cell surface receptor

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31 July 2019

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28 September 2019

inorganic compound

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4 November 2019

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19 November 2019

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20 November 2019

membrane protein

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15 December 2019

vascular endothelial growth factor A

1 reference

20 August 2020

signal transduction

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26 August 2020

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12 September 2020

molecular knots

1 reference

based on heuristic

inferred from title

K. Ravi Acharya

2

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author name string

Shalini Iyer

1

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7 October 2011

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1 November 2011

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20 August 2020

26 August 2020

12 September 2020

10 references

31 July 2019

28 September 2019

4 November 2019

19 November 2019

20 November 2019

15 December 2019

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278

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copyright license

Creative Commons Attribution 2.5 Generic

9 references

Europe PubMed Central

31 July 2019

Europe PubMed Central

28 September 2019

Europe PubMed Central

4 November 2019

Europe PubMed Central

19 November 2019

Europe PubMed Central

20 November 2019

Europe PubMed Central

15 December 2019

Europe PubMed Central

20 August 2020

Europe PubMed Central

26 August 2020

Europe PubMed Central

12 September 2020

Structural determinants of vascular endothelial growth factor-D receptor binding and specificity

1 reference

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Structural Insights into the Binding of Vascular Endothelial Growth Factor-B by VEGFR-1D2: RECOGNITION AND SPECIFICITY

1 reference

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Vascular endothelial growth factor B controls endothelial fatty acid uptake.

1 reference

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Structural determinants of growth factor binding and specificity by VEGF receptor 2

1 reference

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Inhibition of vascular endothelial growth factor receptor signaling in angiogenic tumor vasculature

1 reference

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VEGF-B: a survival, or an angiogenic factor?

1 reference

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11 July 2018

ALINE: a WYSIWYG protein-sequence alignment editor for publication-quality alignments

1 reference

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Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects

1 reference

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Positive and negative modulation of angiogenesis by VEGFR1 ligands

1 reference

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Crystal structure of vascular endothelial growth factor-B in complex with a neutralising antibody Fab fragment

1 reference

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1 reference

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Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos

1 reference

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11 July 2018

The molecular basis of VEGFR-1 signal transduction pathways in primary human monocytes

1 reference

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11 July 2018

Expression and function of vascular endothelial growth factor receptors (Flt-1 and Flk-1) in vascular adventitial fibroblasts

1 reference

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11 July 2018

Crystal structure of the Orf virus NZ2 variant of vascular endothelial growth factor-E. Implications for receptor specificity

1 reference

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11 July 2018

Crystal structure of human vascular endothelial growth factor-B: identification of amino acids important for receptor binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

11 July 2018

Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.

1 reference

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11 July 2018

Vascular endothelial growth factor D is dispensable for development of the lymphatic system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

11 July 2018

Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

11 July 2018

The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

11 July 2018

A set of loop-1 and -3 structures in the novel vascular endothelial growth factor (VEGF) family member, VEGF-ENZ-7, is essential for the activation of VEGFR-2 signaling

1 reference

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11 July 2018

Vascular endothelial growth factors encoded by Orf virus show surprising sequence variation but have a conserved, functionally relevant structure.

1 reference

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11 July 2018

Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

11 July 2018

The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

11 July 2018

Vascular endothelial growth factor: a novel endocrine defensive response to hypoglycemia

1 reference

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11 July 2018

The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis

1 reference

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11 July 2018

Tyrosine residues 951 and 1059 of vascular endothelial growth factor receptor-2 (KDR) are essential for vascular permeability factor/vascular endothelial growth factor-induced endothelium migration and proliferation, respectively

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

11 July 2018

Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules

1 reference

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11 July 2018

VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

11 July 2018

The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

11 July 2018

Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

11 July 2018

Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

11 July 2018

Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

11 July 2018

Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

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VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

11 July 2018

The vascular endothelial growth factor family; proteins which guide the development of the vasculature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

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Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

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Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.

1 reference

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Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis

1 reference

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Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

1 reference

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VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface

1 reference

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11 July 2018

Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells

1 reference

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1 reference

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11 July 2018

Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells

1 reference

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11 July 2018

Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-gamma and migration of endothelial cells expressing Flt 1

1 reference

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11 July 2018

Mapping the charged residues in the second immunoglobulin-like domain of the vascular endothelial growth factor/placenta growth factor receptor Flt-1 required for binding and structural stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

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Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase

1 reference

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Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells

1 reference

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p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

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Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

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Proteolytic processing regulates receptor specificity and activity of VEGF-C.

1 reference

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Molecular cloning of a novel vascular endothelial growth factor, VEGF-D

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1 reference

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1 reference

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1 reference

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1 reference

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

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Signalling mechanisms in the regulation of vascular cell migration

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Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR

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Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

1 reference

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1 reference

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1 reference

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1 reference

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Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis

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1 reference

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Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor

1 reference

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11 July 2018

Identification of a new endothelial cell growth factor receptor tyrosine kinase

1 reference

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11 July 2018

FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

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Vascular endothelial growth factor is essential for corpus luteum angiogenesis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08350.X

21 January 2018

The neural tube patterns vessels developmentally using the VEGF signaling pathway.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08350.X

21 January 2018

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08350.X

21 January 2018

VEGF gene and phenotype relation with Alzheimer's disease and mild cognitive impairment.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08350.X

21 January 2018

Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08350.X

21 January 2018

A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08350.X

21 January 2018

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08350.X

21 January 2018

Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08350.X

21 January 2018

Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08350.X

21 January 2018

The protein kinase MEK1/2 mediate vascular endothelial growth factor- and histamine-induced hyperpermeability in porcine coronary venules

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08350.X

21 January 2018

Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

24 September 2018

Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for placenta growth factor, which is related to vascular endothelial growth factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328748

24 September 2018

Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08350.X

21 January 2018

Vascular endothelial growth factor-D expression in human atherosclerotic lesions

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08350.X

21 January 2018

Viral Vascular Endothelial Growth Factors Vary Extensively in Amino Acid Sequence, Receptor-binding Specificities, and the Ability to Induce Vascular Permeability yet Are Uniformly Active Mitogens

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08350.X

21 January 2018

Placenta growth factor is induced in human keratinocytes during wound healing

1 reference

https://pubmed.ncbi.nlm.nih.gov/21917115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/21917115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/21917115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21917115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: role of flt-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21917115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of peripheral angiogenesis by vascular endothelial growth factor (VEGF)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21917115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21917115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt signaling mediates VEGF/VPF vascular permeability in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21917115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small GTP-Binding Protein Rac Is an Essential Mediator of Vascular Endothelial Growth Factor-Induced Endothelial Fenestrations and Vascular Permeability

1 reference

https://pubmed.ncbi.nlm.nih.gov/21917115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topological similarities in TGF-beta 2, PDGF-BB and NGF define a superfamily of polypeptide growth factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21917115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/21917115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21917115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the heparin-binding region of snake venom vascular endothelial growth factor (VEGF-F) and its blocking of VEGF-A165.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21917115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anti-angiogenic VEGF isoform VEGF165b transiently increases hydraulic conductivity, probably through VEGF receptor 1 in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21917115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1742-4658.2011.08350.X

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21917115%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21917115%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21917115%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

ResearchGate publication ID

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