(Q35905331)

11 August 2017

Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance (English)

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11 August 2017

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Helena Edlund

6

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author name string

Pär Steneberg

1

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11 August 2017

Alexandros G Sykaras

2

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11 August 2017

Fredrik Backlund

3

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11 August 2017

Jurate Straseviciene

4

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11 August 2017

Ingegerd Söderström

5

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11 August 2017

language of work or name

English

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publication date

17 June 2015

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Journal of Biological Chemistry

11 August 2017

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11 August 2017

290

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11 August 2017

31

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11 August 2017

19034-19043

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describes a project that uses

11 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4521028/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice

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27 July 2018

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27 July 2018

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Hyperinsulinemia drives diet-induced obesity independently of brain insulin production

27 July 2018

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Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis

27 July 2018

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27 July 2018

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27 July 2018

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A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats

27 July 2018

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Basal-state hyperinsulinemia in healthy normoglycemic adults is predictive of type 2 diabetes over a 24-year follow-up: a preliminary report

27 July 2018

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Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy

27 July 2018

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Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

27 July 2018

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Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis

27 July 2018

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Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse?

27 July 2018

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Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis.

27 July 2018

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27 July 2018

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27 July 2018

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Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.

27 July 2018

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27 July 2018

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Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes

27 July 2018

1 reference

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Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase

27 July 2018

1 reference

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

27 July 2018

1 reference

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Hepatic over-expression of peroxisome proliferator activated receptor gamma2 in the ob/ob mouse model of non-insulin dependent diabetes mellitus

27 July 2018

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Regulation of putative fatty acid transporters and Acyl-CoA synthetase in liver and adipose tissue in ob/ob mice

27 July 2018

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PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL

27 July 2018

1 reference

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Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.

27 July 2018

1 reference

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Diet-induced type II diabetes in C57BL/6J mice

27 July 2018

1 reference

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Transcriptional and epigenetic regulation of PPARγ expression during adipogenesis

27 July 2018

1 reference

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Increased hepatic CD36 expression with age is associated with enhanced susceptibility to nonalcoholic fatty liver disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4521028

Basal state hyperinsulinemia in healthy normoglycemic adults heralds dysglycemia after more than two decades of follow up.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4521028

Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4521028

Hyperinsulinemia and the development of nonalcoholic Fatty liver disease in nondiabetic adults

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4521028

Insulin acutely upregulates protein expression of the fatty acid transporter CD36 in human skeletal muscle in vivo.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4521028

Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4521028

Insulin and oleic acid increase PPARgamma2 expression in cultured mouse hepatocytes

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4521028

Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4521028

The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4521028

Insulin stimulates fatty acid transport by regulating expression of FAT/CD36 but not FABPpm

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4521028

Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4521028

High insulin levels are required for FAT/CD36 plasma membrane translocation and enhanced fatty acid uptake in obese Zucker rat hepatocytes

24 September 2018

1 reference

12 December 2020

Triacylglycerol-rich lipoproteins protect lipoprotein lipase from inactivation by ANGPTL3 and ANGPTL4

1 reference

12 December 2020

Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts

1 reference

12 December 2020

Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice

1 reference

12 December 2020

Upregulation of liver VLDL receptor and FAT/CD36 expression in LDLR-/- apoB100/100 mice fed trans-10,cis-12 conjugated linoleic acid

1 reference

12 December 2020

Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in

1 reference

12 December 2020

Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M115.640292

1 reference

11 August 2017

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11 August 2017

PubMed publication ID

26085100

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