(Q35906528)

English

Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegeneration

scientific article published on 23 April 2010

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scholarly article

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20399848%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegeneration (English)

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20399848%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

toll-like receptor

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neurodegeneration

1 reference

based on heuristic

inferred from title

Colm Cunningham

5

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31 January 2020

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Robert Field

1

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31 January 2020

Suzanne Campion

2

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31 January 2020

Colleen Warren

3

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31 January 2020

Carol Murray

4

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31 January 2020

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23 April 2010

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31 January 2020

Brain, Behavior, and Immunity

1 reference

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31 January 2020

24

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31 January 2020

6

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31 January 2020

996-1007

1 reference

Europe PubMed Central

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31 January 2020

Attenuation of the influenza virus sickness behavior in mice deficient in Toll-like receptor 3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Systemic inflammation and disease progression in Alzheimer disease

1 reference

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11 July 2018

Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4+ T Cells in MS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Mouse norovirus replication is associated with virus-induced vesicle clusters originating from membranes derived from the secretory pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Delirium accelerates cognitive decline in Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Interferon-alpha causes neuronal dysfunction in encephalitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Peripheral challenge with double-stranded RNA elicits global up-regulation of cytokine gene expression in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

TLR3: interferon induction by double-stranded RNA including poly(I:C).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Differential expression of interferon responsive genes in rodent models of transmissible spongiform encephalopathy disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Noroviruses everywhere: has something changed?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Sleep and body temperature responses in an acute viral infection model are altered in interferon type I receptor-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Preferential expression and function of Toll-like receptor 3 in human astrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Double-stranded RNA enhances the expression of galectin-9 in vascular endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Differential antiviral response of endothelial cells after infection with pathogenic and nonpathogenic hantaviruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Early induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Impact of viral and bacterial burden on cognitive impairment in elderly persons with cardiovascular diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Interleukin 1 in the brain: biology, pathology and therapeutic target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Structural and functional neuropathology in transgenic mice with CNS expression of IFN-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Failure of interferon to modify scrapie in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Interferon System in Mice Infected with the Scrapie Agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Acceleration of scrapie disease in mice by an adenovirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Identification of a second interferon-regulated murine Mx gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Acceleration of scrapie in mice by target-organ treatment with interferon inducers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

11 July 2018

Systemic interferon-alpha regulates interferon-stimulated genes in the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1- and neutrophil-dependent mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

Microglia recognize double-stranded RNA via TLR3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

Peripheral infection and aging interact to impair hippocampal memory consolidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

Neuropathologically distinct prion strains give rise to similar temporal profiles of behavioral deficits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

Gene expression profiling of scrapie-infected brain tissue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

Chronic glial activation, neurodegeneration, and APP immunoreactive deposits following acute administration of double-stranded RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

Prolonged effects of polyriboinosinic:polyribocytidylic acid on spontaneous running wheel activity and brain interferon-alpha mRNA in rats: a model for immunologically induced fatigue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

Characterization and expression of the Mx1 gene in wild mouse species.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

MRI assessment of the blood-brain barrier in a hamster model of scrapie.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

Increased blood-brain barrier permeability in scrapie-infected mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

An attempt to modify scrapie in mice by the administration of interferon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

24 September 2018

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334265

14 November 2018

Stem cell based delivery of IFN-beta reduces relapses in experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20399848

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing

1 reference

https://pubmed.ncbi.nlm.nih.gov/20399848

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Failure to Modify Scrapie in Mice by Administration of Interferon or Anti-interferon Globulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20399848

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20399848

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequential activation of murine mononuclear phagocytes for tumor cytolysis: differential expression of markers by macrophages in the several stages of development

1 reference

https://pubmed.ncbi.nlm.nih.gov/20399848

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A NEW METHOD FOR THE MEASUREMENT OF MUSCLE RELAXATION IN WHITE MICE

1 reference

https://pubmed.ncbi.nlm.nih.gov/20399848

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/20399848

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BBI.2010.04.004

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20399848%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20399848%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20399848%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

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