(Q46303283)

English

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.

scientific article

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192374%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192374%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Alzheimer's disease

0 references

lipopolysaccharide

0 references

0 references

0 references

author name string

Masashi Kitazawa

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192374%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Salvatore Oddo

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192374%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Tritia R Yamasaki

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192374%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Kim N Green

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192374%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Frank M LaFerla

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192374%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

language of work or name

0 references

publication date

1 September 2005

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192374%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192374%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

25

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192374%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

39

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192374%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

8843-8853

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192374%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Association of microglia with amyloid plaques in brains of APP23 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau phosphorylation at serine 396 and serine 404 by human recombinant tau protein kinase II inhibits tau's ability to promote microtubule assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: the Cache County study

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: more than a 'cholinergic disorder' - evidence that cholinergic-monoaminergic interactions contribute to EEG slowing and dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory drugs protect against Alzheimer disease at low doses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The renaissance of GSK3

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1, neuroinflammation, and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase-3beta is complexed with tau protein in brain microtubules

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrovascular transforming growth factor-beta contributes to inflammation in the Alzheimer's disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additive effects of amyloid beta fragment and interleukin-1beta on interleukin-6 secretion in rat primary glial cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia, and the lack of paired helical filament-typed, dystrophic neurites

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5: One of the links between senile plaques and neurofibrillary tangles?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5 is a key factor in tau aggregation and tangle formation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10--a role for IL-1 beta?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of cyclin-dependent kinase-5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the histocompatibility glycoprotein HLA-DR in neurological disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain macrophages synthesize interleukin-1 and interleukin-1 mRNAs in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial interleukin-1 alpha expression in human head injury: correlations with neuronal and neuritic beta-amyloid precursor protein expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk of Alzheimer's disease and duration of NSAID use.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial response to amyloid plaques in APPsw transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-1 beta and IL-6 in mouse parotid acinar cells: characterization of synthesis, storage, and release

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16192374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.2868-05.2005

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192374%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

release_2d55m554bzetnbdgfy2tttkddq

1 reference

https://api.fatcat.wiki/v0/release/2d55m554bzetnbdgfy2tttkddq

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192374%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16192374%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q46303283&oldid=1838623934"