(Q35913889)

11 August 2017

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title

Brain endothelial cells as pharmacological targets in brain tumors (English)

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11 August 2017

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Michel Demeule

1

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11 August 2017

Anthony Régina

2

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11 August 2017

Borhane Annabi

3

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11 August 2017

Yanick Bertrand

4

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11 August 2017

Michel W Bojanowski

5

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11 August 2017

Richard Béliveau

6

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11 August 2017

1 October 2004

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11 August 2017

Molecular Neurobiology

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11 August 2017

30

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11 August 2017

157-183

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11 August 2017

2

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https://scigraph.springernature.com/pub.10.1385/mn:30:2:157

11 August 2017

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cites work

Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain

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12 December 2020

Feasibility of intraventricular administration of etoposide in patients with metastatic brain tumours

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12 December 2020

Distinct antitumor properties of a type IV collagen domain derived from basement membrane

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12 December 2020

Antiangiogenic therapy against experimental glioblastoma using genetically engineered cells producing interferon-alpha, angiostatin, or endostatin

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12 December 2020

The temporal-spatial expression of VEGF, angiopoietins-1 and 2, and Tie-2 during tumor angiogenesis and their functional correlation with tumor neovascular architecture

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12 December 2020

Expression and functional activity of the ABC-transporter proteins P-glycoprotein and multidrug-resistance protein 1 in human brain tumor cells and astrocytes.

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12 December 2020

MDR1 P-glycoprotein is expressed by endothelial cells of newly formed capillaries in human gliomas but is not expressed in the neovasculature of other primary tumors.

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12 December 2020

A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrier

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12 December 2020

Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol.

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12 December 2020

Tissue factor, osteopontin, alphavbeta3 integrin expression in microvasculature of gliomas associated with vascular endothelial growth factor expression

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12 December 2020

Endothelial cell heterogeneity

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12 December 2020

Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM

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12 December 2020

Prolonged treatment with angiostatin reduces metastatic burden during radiation therapy

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12 December 2020

Ionizing radiation modulates cell surface integrin expression and adhesion of COLO-320 cells to collagen and fibronectin in vitro

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12 December 2020

Tumor response to radiotherapy regulated by endothelial cell apoptosis

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12 December 2020

Gene transfer to the central nervous system by transplantation of cerebral endothelial cells.

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12 December 2020

Immunotherapy and biological modifiers for the treatment of malignant brain tumors.

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12 December 2020

The third helix of the Antennapedia homeodomain translocates through biological membranes.

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12 December 2020

Blood-brain barrier biology and methodology

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12 December 2020

Endothelial cell implantation and survival within experimental gliomas

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12 December 2020

Emerging molecular mechanisms of brain tumour oedema.

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12 December 2020

Beta-amyloid (1-42) peptide impairs blood-brain barrier function after intracarotid infusion in rats.

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12 December 2020

Response of bovine endothelial cells to FGF-2 and VEGF is dependent on their site of origin: Relevance to the regulation of angiogenesis

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12 December 2020

Down-regulation of caveolin-1 in glioma vasculature: modulation by radiotherapy.

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12 December 2020

Endothelial differentiation in intracerebral and subcutaneous experimental gliomas.

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12 December 2020

Determinants of passive drug entry into the central nervous system

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12 December 2020

The physiological function of drug-transporting P-glycoproteins

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12 December 2020

Differences in multidrug resistance phenotype and matrix metalloproteinases activity between endothelial cells from normal brain and glioma.

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12 December 2020

Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors

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12 December 2020

In situ visualization of intratumor growth factor signaling: immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms

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12 December 2020

New systems for delivery of drugs to the brain in neurological disease

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12 December 2020

Therapeutic angiogenesis using autologous bone marrow stromal cells: improved blood flow in a chronic limb ischemia model

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12 December 2020

Peptide delivery to the brain via adsorptive-mediated endocytosis: advances with SynB vectors

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12 December 2020

Constitutive activation of Stat3alpha in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2).

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12 December 2020

Emerging role of endothelin-1 in tumor angiogenesis.

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12 December 2020

Vascular proteomics and subtractive antibody expression cloning

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12 December 2020

Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung.

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12 December 2020

Targeting angiogenic processes by combination rofecoxib and ionizing radiation

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12 December 2020

Primary brain tumours in adults.

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12 December 2020

The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone

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12 December 2020

Bone marrow: a possible alternative source of cells in the adult nervous system

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12 December 2020

Characterization of prenylcysteines that interact with P-glycoprotein and inhibit drug transport in tumor cells

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12 December 2020

Radiation-mediated control of drug delivery

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12 December 2020

Pharmacological insights from P-glycoprotein knockout mice.

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12 December 2020

Overcoming Multidrug Resistance in Cancer: An Update on the Clinical Strategy of Inhibiting P-Glycoprotein

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12 December 2020

Effect of VEGF receptor inhibitor PTK787/ZK222584 [correction of ZK222548] combined with ionizing radiation on endothelial cells and tumour growth

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12 December 2020

Localization of endostatin in rat and human gliomas.

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12 December 2020

Identification of a novel family of cell-surface proteins expressed in human vascular endothelium

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12 December 2020

Genes expressed in human tumor endothelium

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12 December 2020

The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation

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12 December 2020

Extent of resection in malignant gliomas: a critical summary.

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12 December 2020

Specific matrix metalloproteinase profiles in the cerebrospinal fluid correlated with the presence of malignant astrocytomas, brain metastases, and carcinomatous meningitis.

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12 December 2020

Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier

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12 December 2020

Promotion of angiogenesis by low energy laser irradiation

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12 December 2020

Downregulation of MMP-9 in ERK-mutated stable transfectants inhibits glioma invasion in vitro

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12 December 2020

UV irradiation upregulates Egr-1 expression at transcription level

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12 December 2020

New chemotherapeutic agents: update of major chemoradiation trials in solid tumors

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12 December 2020

The functional role of P-glycoprotein in the blood-brain barrier

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12 December 2020

Endothelial cell-based systemic gene therapy of metastatic melanoma

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12 December 2020

Role of multidrug resistance P-glycoproteins in cholesterol esterification

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12 December 2020

Poly(ethylene glycol)-coated hexadecylcyanoacrylate nanospheres display a combined effect for brain tumor targeting

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12 December 2020

A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma

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12 December 2020

Marrow stromal cells as stem cells for nonhematopoietic tissues

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12 December 2020

Physiological roles of matrix metalloproteinases: implications for tumor growth and metastasis

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12 December 2020

Overexpression of vascular endothelial growth factor isoforms drives oxygenation and growth but not progression to glioblastoma multiforme in a human model of gliomagenesis.

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12 December 2020

Tat-mediated delivery of heterologous proteins into cells

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12 December 2020

Ultrastructural and morphometric investigation of human brain capillaries in normal and peritumoral tissues

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12 December 2020

Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth

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12 December 2020

Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma

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12 December 2020

Angiogenesis and fibroblast proliferation precede formation of recurrent tumors after radiation therapy in nude mice

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12 December 2020

Quantification and distribution of neovascularization following microinjection of C6 glioma cells in rat brain.

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12 December 2020

Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders

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12 December 2020

In vivo protein transduction: delivery of a biologically active protein into the mouse

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12 December 2020

The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis

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12 December 2020

Pharmacokinetics and blood-brain barrier transport of an anti-transferrin receptor monoclonal antibody (OX26) in rats after chronic treatment with the antibody.

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12 December 2020

Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth

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12 December 2020

Expression of multidrug-resistance P-glycoprotein (MDR1) in human brain tumors.

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12 December 2020

Immunohistochemical study of tight junction-related protein in neovasculature in astrocytic tumor.

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12 December 2020

Egr-1 mediates extracellular matrix-driven transcription of membrane type 1 matrix metalloproteinase in endothelium

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12 December 2020

Reactive oxygen intermediates target CC(A/T)6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation

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12 December 2020

beta-Amyloid efflux mediated by p-glycoprotein

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12 December 2020

Prevention of irradiation-induced glioma cell invasion by temozolomide involves caspase 3 activity and cleavage of focal adhesion kinase.

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12 December 2020

Expression of ET(A) and ET(B) receptor mRNA in human cerebral arteries.

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12 December 2020

Vascular activation of adhesion molecule mRNA and cell surface expression by ionizing radiation

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12 December 2020

A Systematic Overview of Radiation Therapy Effects in Brain Tumours

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12 December 2020

Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 2).

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12 December 2020

Endothelial cell heterogeneity and organ specificity

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12 December 2020

Identification of tumor angiogenesis-related genes by subtractive hybridization

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12 December 2020

beta-Amyloid-mediated vasoactivity and vascular endothelial damage.

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12 December 2020

Alpha(v)beta3 and alpha(v)beta5 integrin expression in glioma periphery.

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12 December 2020

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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12 December 2020

Effect of diabetes on the blood brain barrier

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12 December 2020

Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells.

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12 December 2020

Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade

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12 December 2020

Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest

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12 December 2020

Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels

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12 December 2020

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

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12 December 2020

Facilitation of drug entry into the CNS via transient permeation of blood brain barrier: laboratory and preliminary clinical evidence from bradykinin receptor agonist, Cereport.

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12 December 2020

Irradiation-induced angiogenesis through the up-regulation of the nitric oxide pathway: implications for tumor radiotherapy

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12 December 2020

Postnatal bone marrow stromal cells elicit a potent VEGF-dependent neoangiogenic response in vivo

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12 December 2020

Antiangiogenic activity of endostatin inhibits C6 glioma growth

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12 December 2020

Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1).

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12 December 2020

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

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12 December 2020

The role of matrix metalloproteinase genes in glioma invasion: co-dependent and interactive proteolysis

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12 December 2020

A rat glioma model, CNS-1, with invasive characteristics similar to those of human gliomas: a comparison to 9L gliosarcoma

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12 December 2020

Gene expression of GLUT3 and GLUT1 glucose transporters in human brain tumors.

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12 December 2020

Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation.

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12 December 2020

Brain drug targeting and gene technologies

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12 December 2020

Phase II evaluation of temozolomide and 13-cis-retinoic acid for the treatment of recurrent and progressive malignant glioma: a North American Brain Tumor Consortium study

1 reference

12 December 2020

Combined effects of radiotherapy and angiostatin gene therapy in glioma tumor model

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12 December 2020

Endothelial hyperplasia: an important indicator of actual angiogenesis

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12 December 2020

Phase II studies of RMP-7 and carboplatin in the treatment of recurrent high grade glioma. RMP-7 European Study Group.

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12 December 2020

Physiology and pathology of the blood-brain barrier: implications for microbial pathogenesis, drug delivery and neurodegenerative disorders

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12 December 2020

Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway

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12 December 2020

Intraoperative magnetic resonance imaging and magnetic resonance imaging-guided therapy for brain tumors

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12 December 2020

Analysis of VEGF-responsive genes involved in the activation of endothelial cells

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12 December 2020

Proteolytic remodeling of extracellular matrix

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12 December 2020

Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier.

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12 December 2020

Green tea catechins as novel antitumor and antiangiogenic compounds

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12 December 2020

Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth

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12 December 2020

Localization of gelatinase-A and gelatinase-B mRNA and protein in human gliomas

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12 December 2020

Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis.

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12 December 2020

Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?

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12 December 2020

Angiogenesis in cancer and other diseases

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12 December 2020

Regulation of life and death by the zinc finger transcription factor Egr-1.

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12 December 2020

Caveolae: from cell biology to animal physiology

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12 December 2020

Delivery of peptides and proteins through the blood-brain barrier

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12 December 2020

Vascular-specific growth factors and blood vessel formation

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12 December 2020

Pharmacokinetics and brain uptake of biotinylated basic fibroblast growth factor conjugated to a blood-brain barrier drug delivery system.

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12 December 2020

The endothelin system in human glioblastoma.

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12 December 2020

Targeting microparticles to select tissue via radiation-induced upregulation of endothelial cell adhesion molecules.

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12 December 2020

Origin of endothelial progenitors in human postnatal bone marrow

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12 December 2020

Role of angiogenesis in tumor growth and metastasis

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12 December 2020

Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains

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12 December 2020

Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma

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12 December 2020

Cyclic strain stimulates early growth response gene product 1-mediated expression of membrane type 1 matrix metalloproteinase in endothelium

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12 December 2020

High transcytosis of melanotransferrin (P97) across the blood-brain barrier

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12 December 2020

Gamma knife radiosurgery for the treatment of brain metastases

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12 December 2020

Increased levels of tissue endostatin in human malignant gliomas.

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12 December 2020

Intratumoral gene therapy of malignant brain tumor in a rat model with angiostatin delivered by adeno-associated viral (AAV) vector

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12 December 2020

Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation

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12 December 2020

P-Glycoprotein, a gatekeeper in the blood-brain barrier

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12 December 2020

In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment.

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12 December 2020

Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts

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12 December 2020

Origin and differentiation of human and murine stroma

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12 December 2020

Altered blood-brain-barrier function in Alzheimer's disease?

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12 December 2020

Regulation of MAP kinases by docking domains

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12 December 2020

Vascular progenitors derived from murine bone marrow stromal cells are regulated by fibroblast growth factor and are avidly recruited by vascularizing tumors

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12 December 2020

Radiation induction of immediate early genes: effectors of the radiation-stress response.

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12 December 2020

Primary and secondary glioblastomas: from concept to clinical diagnosis

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12 December 2020

Marrow stromal stem cells

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12 December 2020

Radiation-induced increase in invasive potential of human pancreatic cancer cells and its blockade by a matrix metalloproteinase inhibitor, CGS27023

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12 December 2020

Heterogeneous regional expression patterns of matrix metalloproteinases in human malignant gliomas.

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12 December 2020

Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells

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12 December 2020

Caveolin-1 expression enhances endothelial capillary tubule formation

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12 December 2020

The cell biology of the plasminogen system.

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12 December 2020

Promises and pitfalls of anti-angiogenic therapy in clinical trials

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12 December 2020

Angiogenesis inhibited by drinking tea.

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12 December 2020

IS20I, a specific alphavbeta3 integrin inhibitor, reduces glioma growth in vivo.

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12 December 2020

Randomized trial on the efficacy of radiotherapy for cerebral low-grade glioma in the adult: European Organization for Research and Treatment of Cancer Study 22845 with the Medical Research Council study BRO4: an interim analysis.

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12 December 2020

Diversity in unity: the biochemical composition of the endothelial cell surface varies between the vascular beds

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12 December 2020

Cooperative effect of radioimmunotherapy and antiangiogenic therapy with thalidomide in human cancer xenografts

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12 December 2020

Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier

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12 December 2020

Antivasculature effects of doxorubicin-containing liposomes in an intracranial rat brain tumor model.

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12 December 2020

Isolation of endothelial cells from brain, lung, and kidney: expression of the multidrug resistance P-glycoprotein isoforms

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12 December 2020

Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.

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12 December 2020

Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity

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12 December 2020

Expression of the multidrug-resistance P-glycoprotein (Pgp, MDR-1) by endothelial cells of the neovasculature in central nervous system tumors

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12 December 2020

Carrier-mediated or specialized transport of drugs across the blood-brain barrier

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12 December 2020

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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12 December 2020

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12 December 2020

Changes in multidrug transporter protein expression in endothelial cells cultured from isolated human brain microvessels.

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12 December 2020

Radiation induced-tubulogenesis in endothelial cells is antagonized by the antiangiogenic properties of green tea polyphenol (-) epigallocatechin-3-gallate

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12 December 2020

Benefits of adjuvant chemotherapy in high-grade gliomas.

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12 December 2020

Orthotopic models are necessary to predict therapy of transplantable tumors in mice

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12 December 2020

The role of gamma knife radiosurgery in the treatment of primary and metastatic brain tumors

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12 December 2020

Molecular and functional MDR1-Pgp and MRPs expression in human glioblastoma multiforme cell lines

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12 December 2020

Selective Lutheran glycoprotein gene expression at the blood-brain barrier in normal brain and in human brain tumors

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12 December 2020

A fibronectin fragment inhibits tumor growth, angiogenesis, and metastasis

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12 December 2020

Diet and cancer prevention

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12 December 2020

Identifiers

DOI

10.1385/MN:30:2:157

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Dimensions Publication ID

11 August 2017

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