(Q35918870)

11 August 2017

Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice (English)

1 reference

11 August 2017

1 reference

Rong Deng

1

1 reference

11 August 2017

Y Gloria Meng

2

1 reference

11 August 2017

Kwame Hoyte

3

1 reference

11 August 2017

Jeff Lutman

4

1 reference

11 August 2017

Yanmei Lu

5

1 reference

11 August 2017

Suhasini Iyer

6

1 reference

11 August 2017

Laura E DeForge

7

1 reference

11 August 2017

Frank-Peter Theil

8

1 reference

11 August 2017

Paul J Fielder

9

1 reference

11 August 2017

Saileta Prabhu

10

1 reference

11 August 2017

1 January 2012

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11 August 2017

Monoclonal Antibodies

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11 August 2017

4

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11 August 2017

1

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11 August 2017

101-109

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Identification of IgG(1) variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: comparison of soluble receptor-based and cell-based binding assays

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338944

Analyses of the recycling receptor, FcRn, in live cells reveal novel pathways for lysosomal delivery.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338944

Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338944

FcRn: the neonatal Fc receptor comes of age.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338944

Pharmacokinetic/pharmacodynamic modeling of IVIG effects in a murine model of immune thrombocytopenia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338944

Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338944

Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338944

Pharmacokinetic/pharmacodynamic modeling of the effects of intravenous immunoglobulin on the disposition of antiplatelet antibodies in a rat model of immune thrombocytopenia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338944

Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338944

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338944

Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338944

The SCID mouse mutant: definition, characterization, and potential uses

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338944

Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice.

11 July 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18543

Identifying amino acid residues that influence plasma clearance of murine IgG1 fragments by site-directed mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18543

High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18543

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18543

Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18543

The minipig in dermatotoxicology: methods and challenges.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18543

Monoclonal antibody pharmacokinetics and pharmacodynamics

21 January 2018

1 reference

12 December 2020

Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates

1 reference

12 December 2020

Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-{alpha} antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys

1 reference

12 December 2020

Subcutaneous absorption of monoclonal antibodies: role of dose, site of injection, and injection volume on rituximab pharmacokinetics in rats

1 reference

12 December 2020

Rapid blood clearance of injected mouse IgG2a in SCID mice

1 reference

12 December 2020

The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs

1 reference

12 December 2020

The use of severe combined immunodeficiency mice to study the metabolism of human immunoglobulin G

1 reference

12 December 2020

Chimeric human-mouse IgG antibodies with shuffled constant region exons demonstrate that multiple domains contribute to in vivo half-life

1 reference

12 December 2020

Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice

1 reference

12 December 2020

Identifiers

DOI

10.4161/MABS.4.1.18543

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

22327433

1 reference