(Q35918940)

11 August 2017

Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie (English)

1 reference

11 August 2017

Bruno P Imbimbo

17

1 reference

ORCID Public Data File 2021

author name string

Giorgio Poli

1

1 reference

11 August 2017

Erica Corda

2

1 reference

11 August 2017

Barbara Lucchini

3

1 reference

11 August 2017

Maria Puricelli

4

1 reference

11 August 2017

Piera Anna Martino

5

1 reference

11 August 2017

Paola Dall'ara

6

1 reference

11 August 2017

Gino Villetti

7

1 reference

11 August 2017

Silvio R Bareggi

8

1 reference

11 August 2017

Cristiano Corona

9

1 reference

11 August 2017

Elena Vallino Costassa

10

1 reference

11 August 2017

Paola Gazzuola

11

1 reference

11 August 2017

Barbara Iulini

12

1 reference

11 August 2017

Maria Mazza

13

1 reference

11 August 2017

Pierluigi Acutis

14

1 reference

11 August 2017

Paolo Mantegazza

15

1 reference

11 August 2017

Cristina Casalone

16

1 reference

11 August 2017

1 January 2012

1 reference

11 August 2017

1 reference

11 August 2017

6

1 reference

11 August 2017

1

1 reference

11 August 2017

62-72

1 reference

Memory impairment in transgenic Alzheimer mice requires cellular prion protein

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Prion protein misfolding and disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Role of lipid rafts in the processing of the pathogenic prion and Alzheimer's amyloid-beta proteins

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Prions and peripheral nerves: a deadly rendezvous

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Increased expression of glial cell line-derived neurotrophic factor (GDNF) in the brains of scrapie-infected mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

The prion protein and lipid rafts

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

The prion protein requires cholesterol for cell surface localization.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Notch-1 activation and dendritic atrophy in prion disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Neuropathology and molecular biology of variant Creutzfeldt-Jakob disease.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Alzheimer's and prion diseases: distinct pathologies, common proteolytic denominators.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Chronic subclinical prion disease induced by low-dose inoculum

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

The Notch-Hes pathway in mammalian neural development

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Mice devoid of PrP are resistant to scrapie

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Novel proteinaceous infectious particles cause scrapie

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

The sequential development of the brain lesion of scrapie in three strains of mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Self-replication and scrapie

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Prion infection of mice transgenic for human APPSwe: increased accumulation of cortical formic acid extractable Abeta(1-42) and rapid scrapie disease development

11 July 2018

1 reference

https://api.crossref.org/works/10.4161%2FPRI.6.1.18317

Prion protein codon 129 polymorphism and risk of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FPRI.6.1.18317

Is M129V of PRNP gene associated with Alzheimer's disease? A case-control study and a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FPRI.6.1.18317

Hyaluronic acid induces survival and proliferation of human myeloma cells through an interleukin-6-mediated pathway involving the phosphorylation of retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FPRI.6.1.18317

Binding of prion protein to lipid membranes and implications for prion conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FPRI.6.1.18317

The N-terminal region of the prion protein ectodomain contains a lipid raft targeting determinant

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FPRI.6.1.18317

The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivatives.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

The mouse model for scrapie: inoculation, clinical scoring, and histopathological techniques.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338967

Treatment by CpG or Flt3-ligand does not affect mouse susceptibility to BSE prions

24 September 2018

1 reference

https://api.crossref.org/works/10.4161%2FPRI.6.1.18317

Mouse cortical cells lacking cellular PrP survive in culture with a neurotoxic PrP fragment

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22453180

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Genotyping of the prion protein gene at codon 129

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22453180

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

PrP glycoforms are associated in a strain-specific ratio in native PrPSc

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22453180

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4161/PRI.6.1.18317

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

22453180

1 reference