(Q35929397)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21519954%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism (English)

1 reference

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29 January 2020

0 references

1 reference

9

1 reference

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29 January 2020

author name string

Stepan Melnyk

1

1 reference

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29 January 2020

George J Fuchs

2

1 reference

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29 January 2020

Eldon Schulz

3

1 reference

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29 January 2020

Maya Lopez

4

1 reference

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29 January 2020

Stephen G Kahler

5

1 reference

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29 January 2020

Jill J Fussell

6

1 reference

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29 January 2020

Jayne Bellando

7

1 reference

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29 January 2020

Oleksandra Pavliv

8

1 reference

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29 January 2020

Lisa Seidel

10

1 reference

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29 January 2020

David W Gaylor

11

1 reference

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29 January 2020

S Jill James

12

1 reference

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29 January 2020

language of work or name

English

0 references

publication date

1 March 2012

1 reference

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Journal of Autism and Developmental Disorders

29 January 2020

published in

1 reference

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29 January 2020

volume

42

1 reference

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29 January 2020

issue

3

1 reference

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29 January 2020

page(s)

367-377

1 reference

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Mechanisms involved in the neurotoxic, cognitive, and neurobehavioral effects of alcohol consumption during adolescence

29 January 2020

cites work

1 reference

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Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder

2 October 2017

1 reference

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Redox remodeling as an immunoregulatory strategy

2 October 2017

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Age-dependent decreases in DNA methyltransferase levels and low transmethylation micronutrient levels synergize to promote overexpression of genes implicated in autoimmunity and acute coronary syndromes

2 October 2017

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One-carbon metabolism and schizophrenia: current challenges and future directions.

2 October 2017

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Genomic and epigenetic evidence for oxytocin receptor deficiency in autism

2 October 2017

1 reference

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Investigating the biochemical impact of DNA damage with structure-based probes: abasic sites, photodimers, alkylation adducts, and oxidative lesions

2 October 2017

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Extracellular redox modulation by regulatory T cells

2 October 2017

1 reference

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A role for glutathione in the pathophysiology of bipolar disorder and schizophrenia? Animal models and relevance to clinical practice.

2 October 2017

1 reference

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3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder

2 October 2017

1 reference

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A synaptic trek to autism

2 October 2017

1 reference

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Epigenetic dysregulation in cognitive disorders.

2 October 2017

1 reference

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From trans-methylation to cytosine methylation: evolution of the methylation hypothesis of schizophrenia

2 October 2017

1 reference

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Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism

2 October 2017

1 reference

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Neurometabolic disorders and dysfunction in autism spectrum disorders

2 October 2017

1 reference

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Nuclear and mitochondrial genome defects in autisms

2 October 2017

1 reference

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MECP2 promoter methylation and X chromosome inactivation in autism

2 October 2017

1 reference

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Importance of methyl donors during reproduction

2 October 2017

1 reference

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GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability

2 October 2017

1 reference

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Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism

2 October 2017

1 reference

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The methylation, neurotransmitter, and antioxidant connections between folate and depression

2 October 2017

1 reference

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Improvement of aggressive behavior and quality of life impairment following S-adenosyl-methionine (SAM-e) augmentation in schizophrenia

2 October 2017

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Glutathione: a novel treatment target in psychiatry

2 October 2017

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A mathematical model of glutathione metabolism

2 October 2017

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N-acetyl cysteine as a glutathione precursor for schizophrenia--a double-blind, randomized, placebo-controlled trial

2 October 2017

1 reference

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The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits.

2 October 2017

1 reference

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Epigenomic profiling reveals DNA-methylation changes associated with major psychosis

2 October 2017

1 reference

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Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine

2 October 2017

1 reference

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Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidence

2 October 2017

1 reference

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The role of one-carbon metabolism in schizophrenia and depression

2 October 2017

1 reference

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Stability and flexibility of epigenetic gene regulation in mammalian development

2 October 2017

1 reference

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Strong association of de novo copy number mutations with autism

2 October 2017

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Evidence of toxicity, oxidative stress, and neuronal insult in autism

2 October 2017

1 reference

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Epigenetics of autism spectrum disorders

2 October 2017

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Integrity of the methylation cycle is essential for mammalian neural tube closure.

2 October 2017

1 reference

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Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism

2 October 2017

1 reference

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8-Hydroxy-2'-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures

2 October 2017

1 reference

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Nitrotyrosine and chlorotyrosine: clinical significance and biological functions in the vascular system

2 October 2017

1 reference

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Gene expression profiling reveals a signaling role of glutathione in redox regulation.

2 October 2017

1 reference

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Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3.

2 October 2017

1 reference

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Neuroglial activation and neuroinflammation in the brain of patients with autism

2 October 2017

1 reference

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A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A

2 October 2017

1 reference

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Autism as a disorder of neural information processing: directions for research and targets for therapy

2 October 2017

1 reference

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Model of autism: increased ratio of excitation/inhibition in key neural systems

2 October 2017

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Redox regulation of cell growth and cell death

2 October 2017

1 reference

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Redox state as a central modulator of precursor cell function

2 October 2017

1 reference

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Analysis of glutathione: implication in redox and detoxification

2 October 2017

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The endophenotype concept in psychiatry: etymology and strategic intentions

2 October 2017

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Redox regulation of homocysteine-dependent glutathione synthesis

2 October 2017

1 reference

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Cell signalling and the glutathione redox system

2 October 2017

1 reference

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DNA methylation in cancer: too much, but also too little

2 October 2017

1 reference

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DNA methylation and mammalian epigenetics

2 October 2017

1 reference

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Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

2 October 2017

1 reference

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Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease

2 October 2017

1 reference

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CpG methylation reduces genomic instability.

2 October 2017

1 reference

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DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine

2 October 2017

1 reference

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Disturbances of one-carbon metabolism in neuropsychiatric disorders: a review

2 October 2017

1 reference

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Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS)

2 October 2017

1 reference

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Autism diagnostic observation schedule: a standardized observation of communicative and social behavior

2 October 2017

1 reference

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Investigation of antioxidant enzymes in children with autistic disorder

2 October 2017

1 reference

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Mechanisms for the involvement of DNA methylation in colon carcinogenesis

11 July 2018

1 reference

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The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases

11 July 2018

1 reference

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Longitudinal changes in grey and white matter during adolescence.

24 September 2018

1 reference

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Increase in cerebellar neurotrophin-3 and oxidative stress markers in autism

24 September 2018

1 reference

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N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility

24 September 2018

1 reference

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Novel de novo SHANK3 mutation in autistic patients

24 September 2018

1 reference

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Dietary and genetic compromise in folate availability reduces acetylcholine, cognitive performance and increases aggression: critical role of S-adenosyl methionine

24 September 2018

1 reference

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Altered vascular phenotype in autism: correlation with oxidative stress

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342663

Redox modifications of protein-thiols: emerging roles in cell signaling

24 September 2018

1 reference

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Increased excretion of a lipid peroxidation biomarker in autism.

24 September 2018

1 reference

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Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342663

Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342663

Increased transcription and activity of glutathione synthase in response to deficiencies in folate, vitamin E, and apolipoprotein E.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342663

Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342663

Changes in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autism

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342663

A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry

24 September 2018

1 reference

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Genomic imprinting: mother maintains methylation marks.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3342663

Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo.

24 September 2018

1 reference

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A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection

24 September 2018

1 reference

12 December 2020

Oxidative stress in autism

1 reference

12 December 2020

In vivo oxidative DNA damage: measurement of 8-hydroxy-2'-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection

1 reference

12 December 2020

Measurement of plasma and intracellular S-adenosylmethionine and S-adenosylhomocysteine utilizing coulometric electrochemical detection: alterations with plasma homocysteine and pyridoxal 5'-phosphate concentrations

1 reference

12 December 2020

Formation and efflux of glutathione disulfide studied in isolated rat hepatocytes

1 reference

12 December 2020

Analysis of glutathione and glutathione disulfide in whole cells and mitochondria by postcolumn derivatization high-performance liquid chromatography with ortho-phthalaldehyde

1 reference

12 December 2020

10.1007/S10803-011-1260-7

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21519954%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21519954%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PubMed publication ID

21519954

1 reference