(Q35943365)

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The relative importance of kinetic mechanisms and variable enzyme abundances for the regulation of hepatic glucose metabolism--insights from mathematical modeling

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Europe PubMed Central

PMC publication ID

11 August 2017

The relative importance of kinetic mechanisms and variable enzyme abundances for the regulation of hepatic glucose metabolism--insights from mathematical modeling (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Hermann-Georg Holzhütter

2

object named as

Hermann-Georg Holzhütter

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Nikolaus Berndt

3

object named as

Nikolaus Berndt

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

1

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Sascha Bulik

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

2 March 2016

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

14

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

15

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Refeeding and metabolic syndromes: two sides of the same coin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

2 October 2017

Quantifying the contribution of the liver to glucose homeostasis: a detailed kinetic model of human hepatic glucose metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

2 October 2017

Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

2 October 2017

Citrate Oscillates in Liver and Pancreatic Beta Cell Mitochondria and in INS-1 Insulinoma Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

2 October 2017

Effects of overexpression of the liver subunit of 6-phosphofructo-1-kinase on the metabolism of a cultured mammalian cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

2 October 2017

Reciprocal regulation of glycogen phosphorylase and glycogen synthase by insulin involving phosphatidylinositol-3 kinase and protein phosphatase-1 in HepG2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

2 October 2017

Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

2 October 2017

Quantification of liver and kidney phosphofructokinase by radioimmunoassay in fed, starved and alloxan-diabetic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

2 October 2017

A Linear Steady-State Treatment of Enzymatic Chains. General Properties, Control and Effector Strength

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

2 October 2017

A morphometric study of the removal of phenobarbital-induced membranes from hepatocytes after cessation of threatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

2 October 2017

The synthesis and degradation of rat liver and kidney fructose bisphosphatase in Vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

2 October 2017

Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

2 October 2017

Regulation of phosphofructokinase activity by glucagon in isolated rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

2 October 2017

Determination of mitochondrial/cytosolic metabolite gradients in isolated rat liver cells by cell disruption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

2 October 2017

The endogenous citric acid-cycle intermediates and amino acids of mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Effect of feeding, fasting, and diabetes on liver glycogen synthase activity, protein, and mRNA in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

The onset of liver glycogen synthesis in fasted-refed rats. Effects of streptozocin diabetes and of peripheral insulin replacement.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Concentration of free oxaloacetate in the mitochondrial compartment of isolated liver cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Hormonal control of fructose 2,6-bisphosphate concentration in isolated rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

The role of fructose 2,6-bisphosphate in the long-term control of phosphofructokinase in rat liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Phosphopyruvate carboxylase induction by l-tryptophan. Effects on synthesis and degradation of the enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Influence of fasting and hemin on microsomal cytochromes and enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Thiamin deficiency: liver metabolite levels and redox and phosphorylation states in thiamin-deficient rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Effects of glucose feeding, cortisol, and insulin on liver glycogen synthesis in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Effects of hormonal and nutritional changes on rates of synthesis and degradation of hepatic phosphofructokinase isozymes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Inhibition of glycogenolysis and glycogen phosphorylase by insulin and proinsulin in rat hepatocyte cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Effect of pinealectomy on plasma glucose, insulin and glucagon levels in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Hepatic carbon flux after re-feeding in the glycogen-storage-disease (gsd/gsd) rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

The disposition of carbohydrate between glycogenesis, lipogenesis and oxidation in liver during the starved-to-fed transition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Relationship of hepatic glucose uptake to intrahepatic glucose concentration in fasted rats after glucose load.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Induction of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase mRNA by refeeding and insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Influence of long-term diabetes on liver glycogen metabolism in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Differential regulation of two glucose transporters in rat liver by fasting and refeeding and by diabetes and insulin treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Modulation of the phosphorylation state of rat liver pyruvate kinase by allosteric effectors and insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Control of blood glucose levels in the streptozotocin diabetic rat using a long-acting heat-treated insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

11 July 2018

Decreased hepatic phosphatidylinositol-3,4,5-triphosphate (PIP3) levels and impaired glucose homeostasis in type 1 and type 2 diabetic rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

Targeting hepatic glucokinase in type 2 diabetes: weighing the benefits and risks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

The intravenous glucose tolerance test in cannulated Wistar rats: a robust method for the in vivo assessment of glucose-stimulated insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

Time-dependent hierarchical regulation analysis: deciphering cellular adaptation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

Synthesis and degradation of phosphoenolpyruvate carboxylase in rat liver and adipose tissue. Changes during a starvation-re-feeding cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

Regulation of alpha-cell function by the beta-cell during hypoglycemia in Wistar rats: the "switch-off" hypothesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

Hepatic glucokinase in the fed, fasted, and alloxan-diabetic rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

Allosteric activators of glucokinase: potential role in diabetes therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

Regulation of glycolytic flux in ischemic preconditioning. A study employing metabolic control analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

A daily rhythm in glucose tolerance: a role for the suprachiasmatic nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

A suprachiasmatic nucleus generated rhythm in basal glucose concentrations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

The role of glucose-6-phosphatase in the action of insulin on hepatic glucose production in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

Hepatic lobular patterns of phosphoenolpyruvate carboxykinase, glycogen synthase, and glycogen phosphorylase in fasted and fed rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

Effect of streptozotocin-induced diabetes mellitus on the turnover of rat liver pyruvate carboxylase and pyruvate dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

Turnover of liver pyruvate kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

Regulation of peripheral insulin/glucagon levels by rat liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

Control of gluconeogenesis in liver. II. Effects of glucagon, catecholamines, and adenosine 3',5'-monophosphate on gluconeogenesis in the perfused rat liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774192

24 September 2018

Control analysis of metabolic systems

1 reference

https://api.crossref.org/works/10.1186%2FS12915-016-0237-6

21 January 2018

Regulation of Glycogen Synthesis in Rat-Hepatocyte Cultures by Glucose, Insulin and Glucocorticoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased responses of glucagon and glucose production to hypoglycemia with intraperitoneal versus subcutaneous insulin treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic Enzyme Activities in Streptozotocin-Diabetic Rats Before and After Insulin Treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of alloxan diabetes on the turnover of rat liver glycogen synthase. Comparison with liver phosphorylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of diabetes, insulin, starvation, and refeeding on the level of rat hepatic fructose 2,6-bisphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral administration of vanadate to diabetic rats restores liver 6-phosphofructo-2-kinase content and mRNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic zonation in liver of diabetic rats. Zonal distribution of phosphoenolpyruvate carboxykinase, pyruvate kinase, glucose-6-phosphatase and succinate dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose Transporter Levels in Tissues of Spontaneously Diabetic Zucker fa/fa Rat (ZDF/drt) and Viable Yellow Mouse (Avy/a)

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of glucagon response to hypoglycemia in long-term experimental diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of mixed-function oxidation with biosynthetic processes. 1. Inhibition of gluconeogenesis by aminopyrine in perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of metabolites between the cytosolic and mitochondrial compartments of hepatocytes isolated from fed rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Starvation or diabetes decreases the content but not the mRNA of 6-phosphofructo-2-kinase in rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of starvation in the rat on metabolite concentrations in blood, liver and skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of antidiabetic compounds on glyoxalase I activity in experimental diabetic rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of rat liver fructose 2,6-bisphosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diurnal changes in plasma glucose and insulin responses to oral glucose load in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial transmembrane ion distribution during anoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CONTROL OF GLUCONEOGENESIS IN THE PERFUSED LIVER OF NORMAL AND ADRENALECTOMIZED RATS

1 reference

https://pubmed.ncbi.nlm.nih.gov/26935066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S12915-016-0237-6

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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