(Q35951819)

11 August 2017

1 reference

title

Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. (English)

1 reference

11 August 2017

Wendy T Watford

1

1 reference

11 August 2017

Bruce D Hissong

2

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11 August 2017

Jay H Bream

3

1 reference

11 August 2017

Yuka Kanno

4

1 reference

11 August 2017

Linda Muul

5

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11 August 2017

John J O'Shea

6

1 reference

11 August 2017

language of work or name

1 reference

1 December 2004

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11 August 2017

published in

Immunological Reviews

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11 August 2017

volume

202

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11 August 2017

page(s)

139-156

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Toll-like receptors and innate immunity

11 August 2017

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Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages

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Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction

21 January 2018

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Differential Regulation of Interleukin (IL)-12 p35 and p40 Gene Expression and Interferon (IFN)-γ–primed IL-12 Production by IFN Regulatory Factor 1

21 January 2018

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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

21 January 2018

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Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris

21 January 2018

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Regulation of virus-induced IL-12 and IL-23 expression in human macrophages

21 January 2018

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A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

21 January 2018

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Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

21 January 2018

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T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

21 January 2018

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Selective expression of an interleukin-12 receptor component by human T helper 1 cells

21 January 2018

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A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

21 January 2018

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Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases

21 January 2018

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Partial impairment of cytokine responses in Tyk2-deficient mice

21 January 2018

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Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

21 January 2018

1 reference

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Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling

21 January 2018

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IFN-gamma production by antigen-presenting cells: mechanisms emerge.

21 January 2018

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Serine phosphorylation of STATs

21 January 2018

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IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells

21 January 2018

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Type I interferons and the Th1/Th2 paradigm

21 January 2018

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Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling

21 January 2018

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Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain

21 January 2018

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MAP kinases in the immune response

21 January 2018

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Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway

21 January 2018

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Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice

21 January 2018

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Sphingosine 1-phosphate, a key cell signaling molecule

21 January 2018

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Positive modulation of IL-12 signaling by sphingosine kinase 2 associating with the IL-12 receptor beta 1 cytoplasmic region

21 January 2018

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Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity

21 January 2018

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TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes

21 January 2018

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Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways

21 January 2018

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Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

21 January 2018

1 reference

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Inhibition of NF-kappa B activity in T and NK cells results in defective effector cell expansion and production of IFN-gamma required for resistance to Toxoplasma gondii.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

SOCS3 regulates the plasticity of gp130 signaling

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

SOCS3 negatively regulates IL-6 signaling in vivo

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Specific down-regulation of interleukin-12 signaling through induction of phospho-STAT4 protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

SYNERGISTIC PROLIFERATION AND ACTIVATION OF NATURAL KILLER CELLS BY INTERLEUKIN 12 AND INTERLEUKIN 18

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways

21 January 2018

1 reference

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21 January 2018

1 reference

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Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

21 January 2018

1 reference

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Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

21 January 2018

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

21 January 2018

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Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent

21 January 2018

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Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii

21 January 2018

1 reference

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Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi

21 January 2018

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Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis

21 January 2018

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CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism

21 January 2018

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Jaks, STATs, Cytokines, and Sepsis

21 January 2018

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TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

21 January 2018

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A role for IFN-alpha beta in virus infection-induced sensitization to endotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

The susceptibility to experimental myasthenia gravis of STAT6-/- and STAT4-/- BALB/c mice suggests a pathogenic role of Th1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice.

21 January 2018

1 reference

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Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis

21 January 2018

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STAT4 signal pathways regulate inflammation and airway physiology changes in allergic airway inflammation locally via alteration of chemokines

21 January 2018

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Mechanistic insights into impaired dendritic cell function by rapamycin: inhibition of Jak2/Stat4 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Genetic dissection of immunity to mycobacteria: the human model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

The role of interleukin-12 in human infectious diseases: only a faint signature

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Atopy and mutations of IL-12 receptor beta 2 chain gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Mutations of the IL-12 receptor beta2 chain gene in atopic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Impairment of IL-12-dependent STAT4 nuclear translocation in a patient with recurrent Mycobacterium avium infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

The lineage decisions of helper T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

A novel transcription factor, T-bet, directs Th1 lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Role of T-bet in commitment of TH1 cells before IL-12-dependent selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Interleukin-12 antagonists as new therapeutic agents in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

A protein tyrosine kinase in the interferon alpha/beta signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

A heritable defect in IL-12 signaling in B10.Q/J mice. I. In vitro analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

A heritable defect in IL-12 signaling in B10.Q/J mice. II. Effect on acute resistance to Toxoplasma gondii and rescue by IL-18 treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Components of a Stat recognition code: evidence for two layers of molecular selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Potential targets of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for multiple sclerosis therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

A novel anti-inflammatory role for simvastatin in inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Intracellular thiols contribute to Th2 function via a positive role in IL-4 production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

The biology of Stat4 and Stat6

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

The roles of IL-12 in providing a third signal for clonal expansion of naive CD8 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Transcript imaging of the development of human T helper cells using oligonucleotide arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Induction of the 2B9 antigen/dipeptidyl peptidase IV/CD26 on human natural killer cells by IL-2, IL-12 or IL-15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

Interleukin-12 induces expression of interferon regulatory factor-1 via signal transducer and activator of transcription-4 in human T helper type 1 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00211.X

10.1111/J.0105-2896.2004.00211.X

21 January 2018

Identifiers

DOI

1 reference

11 August 2017

1 reference