(Q35956449)

English

Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia

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Europe PubMed Central

PMC publication ID

11 August 2017

Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

author name string

Nobuyuki Fujita

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Dessislava Markova

2

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

D Greg Anderson

3

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Kazuhiro Chiba

4

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Yoshiaki Toyama

5

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Irving M Shapiro

6

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Makarand V Risbud

7

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

language of work or name

0 references

publication date

26 March 2012

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

11 August 2017

287

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

20

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

16975-16986

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Regulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Prolyl hydroxylase domain protein 3 targets Pax2 for destruction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Inhibition of hypoxia-inducible factor-targeting prolyl hydroxylase domain-containing protein 2 (PHD2) enhances matrix synthesis by human chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-kappaB-dependent pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

HIF-dependent induction of adenosine A2B receptor in hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

2 October 2017

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

11 July 2018

Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

11 July 2018

Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351286

11 July 2018

Vertebral endplate architecture and vascularization: application of micro-computerized tomography, a vascular tracer, and immunocytochemistry in analyses of disc degeneration in the aging sand rat.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.334466

21 January 2018

Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.334466

21 January 2018

Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.334466

21 January 2018

Hypoxia-inducible factor-1-mediated regulation of semaphorin 4D affects tumor growth and vascularity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.334466

21 January 2018

Magnetic resonance classification of lumbar intervertebral disc degeneration.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.334466

21 January 2018

Upper thoracic-spine disc degeneration in patients with cervical pain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.334466

21 January 2018

The Human Intervertebral Disc: A Micro-Angiographical Study on Its Vascular Supply at Various Ages

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.334466

21 January 2018

Lymph and blood supply of the human intervertebral disc. Cadaver study of correlations to discitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ingrowth of blood vessels in disc degeneration. Angiographic and histological studies of cadaveric spines

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.334466

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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