(Q35958460)

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Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Robert V Farese

7

object named as

Robert V Farese

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Europe PubMed Central

PMC publication ID

11 August 2017

author name string

Jun Zhang

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Kathryn L Kelley

2

1 reference

Europe PubMed Central

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11 August 2017

Stephanie M Marshall

3

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Matthew A Davis

4

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Martha D Wilson

5

1 reference

Europe PubMed Central

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11 August 2017

Janet K Sawyer

6

1 reference

Europe PubMed Central

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11 August 2017

J Mark Brown

8

1 reference

Europe PubMed Central

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11 August 2017

Lawrence L Rudel

9

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Europe PubMed Central

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11 August 2017

language of work or name

1 reference

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publication date

29 March 2012

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Europe PubMed Central

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11 August 2017

Journal of Lipid Research

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Europe PubMed Central

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11 August 2017

53

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Europe PubMed Central

PMC publication ID

11 August 2017

6

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Europe PubMed Central

PMC publication ID

11 August 2017

1144-1152

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Europe PubMed Central

PMC publication ID

11 August 2017

Cholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351821

2 October 2017

Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351821

2 October 2017

Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351821

2 October 2017

Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351821

2 October 2017

LDL cholesteryl oleate as a predictor for atherosclerosis: evidence from human and animal studies on dietary fat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351821

2 October 2017

Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351821

2 October 2017

Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351821

2 October 2017

ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351821

2 October 2017

The metabolism of chylomicron cholesterol ester in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351821

2 October 2017

Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351821

2 October 2017

Acyl-coenzyme A:cholesteryl acyltransferase 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351821

2 October 2017

Hepatic origin of cholesteryl oleate in coronary artery atherosclerosis in African green monkeys. Enrichment by dietary monounsaturated fat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351821

2 October 2017

Absorption and metabolism of dietary cholesterol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351821

2 October 2017

Cholesterol ester metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351821

2 October 2017

Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351821

2 October 2017

Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351821

27 July 2018

Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M024356

21 January 2018

Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M024356

21 January 2018

ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M024356

21 January 2018

Cholesterol accumulation and liver cell death in mice with Niemann-Pick type C disease

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M024356

21 January 2018

Dose-comparison study of the combination of ezetimibe and simvastatin (Vytorin) versus atorvastatin in patients with hypercholesterolemia: the Vytorin Versus Atorvastatin (VYVA) study

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M024356

21 January 2018

Effectiveness and tolerability of ezetimibe in patients with primary hypercholesterolemia: pooled analysis of two phase II studies

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M024356

21 January 2018

Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of acyl CoA:cholesterol acyltransferase in cholesterol absorption and its inhibition by 57-118 in the rabbit

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo evidence that the lipid-regulating activity of the ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CI-1011 lowers lipoprotein(a) and plasma cholesterol concentrations in chow-fed cynomolgus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver-specific inhibition of acyl-coenzyme a:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysosomal unesterified cholesterol content correlates with liver cell death in murine Niemann-Pick type C disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1194/JLR.M024356

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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