(Q35960308)

English

Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Mycobacterium tuberculosis

0 references

author name string

Amanda S Fivian-Hughes

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Joanna Houghton

2

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Elaine O Davis

3

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

27 October 2011

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

158

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Pt 2

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

308-318

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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1 reference

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Forkhead-associated (FHA) domain containing ABC transporter Rv1747 is positively regulated by Ser/Thr phosphorylation in Mycobacterium tuberculosis

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The challenge of new drug discovery for tuberculosis

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1 reference

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Thr202Ala in thyA is a marker for the Latin American Mediterranean lineage of the Mycobacterium tuberculosis complex rather than para-aminosalicylic acid resistance.

1 reference

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1 reference

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Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase

1 reference

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An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

1 reference

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Molecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis

1 reference

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Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX

1 reference

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Functional analysis of the Mycobacterium tuberculosis FAD-dependent thymidylate synthase, ThyX, reveals new amino acid residues contributing to an extended ThyX motif.

1 reference

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Global transcriptional profile of Mycobacterium tuberculosis during THP-1 human macrophage infection

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Silencing Mycobacterium smegmatis by using tetracycline repressors

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Global incidence of multidrug-resistant tuberculosis

1 reference

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2 October 2017

Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution

1 reference

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A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor

1 reference

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Genomics of Mycobacterium tuberculosis: old threats & new trends.

1 reference

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The temporal expression profile of Mycobacterium tuberculosis infection in mice.

1 reference

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Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment

1 reference

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Genes required for mycobacterial growth defined by high density mutagenesis

1 reference

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2 October 2017

The use and analysis of microarray data

1 reference

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2 October 2017

Genetic evidence for a novel thymidylate synthase in the halophilic archaeon Halobacterium salinarum and in Campylobacter jejuni

1 reference

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2 October 2017

An alternative flavin-dependent mechanism for thymidylate synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352284

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Use of a flexible cassette method to generate a double unmarked Mycobacterium tuberculosis tlyA plcABC mutant by gene replacement

1 reference

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Cloning and expression of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase in Escherichia coli

1 reference

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The catalytic mechanism and structure of thymidylate synthase

1 reference

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Synthesis and evaluation of 5-substituted 2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis

1 reference

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Development of a repressible mycobacterial promoter system based on two transcriptional repressors

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Usefulness of resistant gene markers for predicting treatment outcome on second-line anti-tuberculosis drugs

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Alternative thymidylate synthase, ThyX, involved in Corynebacterium glutamicum ATCC 13032 survival during stationary growth phase

1 reference

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Biochemical characterization of two thymidylate synthases in Corynebacterium glutamicum NCHU 87078.

1 reference

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Mutations in the thymidylate synthase gene is a major mechanism in the para-aminosalicylic acid resistance of M. tuberculosis

1 reference

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Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Life without dihydrofolate reductase FolA.

1 reference

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1 reference

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Intracellular gene expression. Analysis of RNA from mycobacteria in macrophages using RT-PCR

1 reference

https://pubmed.ncbi.nlm.nih.gov/22034487

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NADP+ expels both the co-factor and a substrate analog from the Mycobacterium tuberculosis ThyX active site: opportunities for anti-bacterial drug design

1 reference

https://pubmed.ncbi.nlm.nih.gov/22034487

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based on heuristic

inferred from PubMed ID database lookup

Instability and site-specific excision of integration-proficient mycobacteriophage L5 plasmids: development of stably maintained integrative vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22034487

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1099/MIC.0.053983-0

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

ResearchGate publication ID

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