(Q35961500)

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Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking

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Europe PubMed Central

PMC publication ID

11 August 2017

Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

energy efficiency

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based on heuristic

inferred from title

Victor V Maltsev

object named as

Victor A Maltsev

1

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Edward G. Lakatta

2

object named as

Edward G Lakatta

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Europe PubMed Central

PMC publication ID

11 August 2017

language of work or name

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publication date

16 March 2013

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Europe PubMed Central

PMC publication ID

11 August 2017

Journal of Molecular and Cellular Cardiology

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Europe PubMed Central

PMC publication ID

11 August 2017

59

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Europe PubMed Central

PMC publication ID

11 August 2017

181-195

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18.

1 reference

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2 October 2017

Ca(2+)-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2

1 reference

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2 October 2017

Ca2+-activated adenylyl cyclase 1 introduces Ca2+-dependence to beta-adrenergic stimulation of HCN2 current

1 reference

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Ca2+-regulated-cAMP/PKA signaling in cardiac pacemaker cells links ATP supply to demand

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2 October 2017

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis

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2 October 2017

Rhythmic beating of stem cell-derived cardiac cells requires dynamic coupling of electrophysiology and Ca cycling

1 reference

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2 October 2017

A novel quantitative explanation for the autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteins.

1 reference

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2 October 2017

A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.

1 reference

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2 October 2017

Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).

1 reference

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2 October 2017

Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model.

1 reference

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2 October 2017

Ca(2+) -stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells

1 reference

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2 October 2017

HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice

1 reference

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2 October 2017

Biological pacemakers based on I(f).

1 reference

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2 October 2017

Computer modelling of the sinoatrial node

1 reference

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2 October 2017

Fundamental importance of Na+-Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node

1 reference

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2 October 2017

Cardiac Action and Pacemaker Potentials based on the Hodgkin-Huxley Equations

1 reference

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2 October 2017

Biological pacemaker created by gene transfer

1 reference

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2 October 2017

Ca2+-stimulated adenylyl cyclase isoform AC1 is preferentially expressed in guinea-pig sino-atrial node cells and modulates the I(f) pacemaker current

1 reference

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11 July 2018

Correlation between electrical activity and the size of rabbit sino-atrial node cells

1 reference

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11 July 2018

Reciprocal role of the inward currents ib, Na and i(f) in controlling and stabilizing pacemaker frequency of rabbit sino-atrial node cells

1 reference

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11 July 2018

Roles of sarcoplasmic reticulum Ca2+ cycling and Na+/Ca2+ exchanger in sinoatrial node pacemaking: insights from bifurcation analysis of mathematical models.

1 reference

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24 September 2018

Minor contribution of cytosolic Ca2+ transients to the pacemaker rhythm in guinea pig sinoatrial node cells.

1 reference

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24 September 2018

Impact of ionic current variability on human ventricular cellular electrophysiology.

1 reference

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24 September 2018

Roles of L-type Ca2+ and delayed-rectifier K+ currents in sinoatrial node pacemaking: insights from stability and bifurcation analyses of a mathematical model

1 reference

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24 September 2018

Dynamical description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cell

1 reference

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24 September 2018

Heterogeneous expression of Ca(2+) handling proteins in rabbit sinoatrial node

1 reference

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24 September 2018

Sinoatrial nodal cell ryanodine receptor and Na(+)-Ca(2+) exchanger: molecular partners in pacemaker regulation

1 reference

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24 September 2018

A sustained inward current activated at the diastolic potential range in rabbit sino-atrial node cells.

1 reference

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24 September 2018

Facilitation of the L-type calcium current in rabbit sino-atrial cells: effect on cardiac automaticity

1 reference

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7 January 2021

Ionic mechanisms underlying the positive chronotropy induced by beta1-adrenergic stimulation in guinea pig sinoatrial node cells: a simulation study

1 reference

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Alternative to hand-tuning conductance-based models: construction and analysis of databases of model neurons

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Similar network activity from disparate circuit parameters

1 reference

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10.1016/J.YJMCC.2013.03.004

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

release_p3qbe6y7k5aktkoqzkfwswouua

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24 November 2022

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

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Europe PubMed Central

PMC publication ID

11 August 2017

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