(Q35968398)

11 August 2017

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title

Making protein interactions druggable: targeting PDZ domains (English)

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11 August 2017

Kumlesh K Dev

1

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11 August 2017

publication date

1 December 2004

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Nature Reviews Drug Discovery

11 August 2017

published in

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11 August 2017

volume

3

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11 August 2017

issue

12

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11 August 2017

page(s)

1047-1056

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

11 August 2017

cites work

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Modulation of protein-protein interactions with small organic molecules

21 January 2018

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Small-molecule inhibitors of the p53 suppressor HDM2: have protein-protein interactions come of age as drug targets?

21 January 2018

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PDZ domain proteins of synapses

21 January 2018

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Functional roles of protein interactions with AMPA and kainate receptors

21 January 2018

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Proteins interactions implicated in AMPA receptor trafficking: a clear destination and an improving route map.

21 January 2018

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The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein

21 January 2018

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The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

21 January 2018

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The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy

21 January 2018

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Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex

21 January 2018

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Recognition of unique carboxyl-terminal motifs by distinct PDZ domains

21 January 2018

1 reference

PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system

21 January 2018

1 reference

Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha

21 January 2018

1 reference

The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits

21 January 2018

1 reference

Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1

21 January 2018

1 reference

Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site.

21 January 2018

1 reference

Molecular determinants for PICK1 synaptic aggregation and mGluR7a receptor coclustering: role of the PDZ, coiled-coil, and acidic domains

21 January 2018

1 reference

NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex

21 January 2018

1 reference

Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors

21 January 2018

1 reference

BAR domains as sensors of membrane curvature: the amphiphysin BAR structure

21 January 2018

1 reference

The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways

21 January 2018

1 reference

PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells

21 January 2018

1 reference

Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1

21 January 2018

2 references

21 January 2018

Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons

31 March 2020

1 reference

Phosphorylation of 46-kDa protein of synaptic vesicle membranes is stimulated by GTP and Ca2+/calmodulin

21 January 2018

1 reference

Regulation of mglu(7) receptors by proteins that interact with the intracellular C-terminus

21 January 2018

1 reference

The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin

21 January 2018

1 reference

The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs

21 January 2018

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Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP

21 January 2018

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Interaction of the C-terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1.

21 January 2018

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GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors

21 January 2018

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Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP

21 January 2018

1 reference

Different binding motifs in metabotropic glutamate receptor type 7b for filamin A, protein phosphatase 1C, protein interacting with protein kinase C (PICK) 1 and syntenin allow the formation of multimeric protein complexes

21 January 2018

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PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7

21 January 2018

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Axon/dendrite targeting of metabotropic glutamate receptors by their cytoplasmic carboxy-terminal domains

21 January 2018

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Immunolocalization of PICK1 in the ascending auditory pathways of the adult rat.

21 January 2018

1 reference

Specific involvement in neuropathic pain of AMPA receptors and adapter proteins for the GluR2 subunit

21 January 2018

1 reference

Eph signaling: a structural view

21 January 2018

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PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands

21 January 2018

1 reference

EphB2 guides axons at the midline and is necessary for normal vestibular function

21 January 2018

1 reference

Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin

21 January 2018

1 reference

The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins

21 January 2018

1 reference

A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth

21 January 2018

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Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1

21 January 2018

1 reference

Monoamine transporters: from genes to behavior

21 January 2018

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Plasma membrane monoamine transporters: structure, regulation and function

21 January 2018

1 reference

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

21 January 2018

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Mice lacking the norepinephrine transporter are supersensitive to psychostimulants

21 January 2018

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Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions.

21 January 2018

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cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1

21 January 2018

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The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons

21 January 2018

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Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)

21 January 2018

1 reference

Protein kinase C stimulates the acid-sensing ion channel ASIC2a via the PDZ domain-containing protein PICK1.

21 January 2018

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ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1

21 January 2018

1 reference

PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses.

21 January 2018

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NSF binding to GluR2 regulates synaptic transmission

21 January 2018

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Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins.

21 January 2018

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Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression.

21 January 2018

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Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression.

21 January 2018

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Phosphorylation of serine-880 in GluR2 by protein kinase C prevents its C terminus from binding with glutamate receptor-interacting protein

21 January 2018

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Regulation of synaptic strength and AMPA receptor subunit composition by PICK1

21 January 2018

1 reference

Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila

21 January 2018

1 reference

Assembly of Cell Regulatory Systems Through Protein Interaction Domains

21 January 2018

1 reference

Transduction peptides: from technology to physiology

21 January 2018

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N-methyl-D-aspartate-induced alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor down-regulation involves interaction of the carboxyl terminus of GluR2/3 with Pick1. Ligand-binding studies using Sindbis vectors carrying AMPA re

21 January 2018

1 reference

Gene transfer into neurons from hippocampal slices: comparison of recombinant Semliki Forest Virus, adenovirus, adeno-associated virus, lentivirus, and measles virus.

21 January 2018

1 reference

A peptide carrier for the delivery of biologically active proteins into mammalian cells.

21 January 2018

1 reference

Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions

21 January 2018

1 reference

A selective irreversible inhibitor targeting a PDZ protein interaction domain.

21 January 2018

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Role of electrostatic interactions in PDZ domain ligand recognition

21 January 2018

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Intracellular antibodies and challenges facing their use as therapeutic agents

21 January 2018

1 reference

RNA interference: the silent treatment.

21 January 2018

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Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons

21 January 2018

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Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

21 January 2018

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Classification of PDZ domains

21 January 2018

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Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition

21 January 2018

1 reference

Inhibition of protein-protein association by small molecules: approaches and progress

21 January 2018

1 reference

Mutagenesis reveals a role for ABP/GRIP binding to GluR2 in synaptic surface accumulation of the AMPA receptor

21 January 2018

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The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.

21 January 2018

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Investigation of the PDZ domain ligand binding site using chemically modified peptides.

21 January 2018

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Organization of signaling complexes by PDZ-domain scaffold proteins

21 January 2018

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A PDZ domain-based detection system for enzymatic assays

21 January 2018

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Expression of transcripts encoding AMPA receptor subunits and associated postsynaptic proteins in the macaque brain

21 January 2018

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Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons

21 January 2018

1 reference

Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle

21 January 2018

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Epidermolysis bullosa and embryonic lethality in mice lacking the multi-PDZ domain protein GRIP1.

21 January 2018

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AMPA receptor–PDZ interactions in facilitation of spinal sensory synapses

21 January 2018

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PDZ domains: targeting signalling molecules to sub-membranous sites

21 January 2018

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PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane

31 March 2020

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PICK1 targets activated protein kinase Calpha to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA-type glutamate receptor subunit 2.

31 March 2020

1 reference

Ionotropic glutamate receptor biology: effect on synaptic connectivity and function in neurological disease

31 March 2020

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PICK1 interacts with and regulates PKC phosphorylation of mGLUR7

31 March 2020

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Surface expression of the netrin receptor UNC5H1 is regulated through a protein kinase C-interacting protein/protein kinase-dependent mechanism.

31 March 2020

1 reference

Neuron-to-glia signaling mediated by excitatory amino acid receptors regulates ErbB receptor function in astroglial cells of the neuroendocrine brain

31 March 2020

1 reference

Association study of PICK1 rs3952 polymorphism and schizophrenia

31 March 2020

1 reference

Intracellullar peptides as putative natural regulators of protein interactions

31 March 2020

1 reference

Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins

31 March 2020

1 reference

A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders

31 March 2020

1 reference

Phosphoinositide recognition domains

31 March 2020

1 reference

SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor

31 March 2020

1 reference

Differential cellular and subcellular localization of ampa receptor-binding protein and glutamate receptor-interacting protein.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD1578

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Dimensions Publication ID

11 August 2017

1036543230

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