(Q35226332)

7 August 2017

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title

Intracellular antibodies and challenges facing their use as therapeutic agents (English)

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7 August 2017

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Terence H Rabbitts

2

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author name string

M Natividad Lobato

series ordinal

1

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7 August 2017

1 September 2003

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Trends in Molecular Medicine

7 August 2017

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7 August 2017

9

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7 August 2017

9

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7 August 2017

390-396

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Single-chain antigen-binding proteins

7 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Design, intracellular expression, and activity of a human anti-human immunodeficiency virus type 1 gp120 single-chain antibody

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Stability engineering of antibody single-chain Fv fragments

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

An intrinsically stable antibody scFv fragment can tolerate the loss of both disulfide bonds and fold correctly.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Antibody scFv fragments without disulfide bonds made by molecular evolution

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Removal of the conserved disulfide bridges from the scfv fragment of an antibody: effects on folding kinetics and aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Mutual Stabilization of VLand VHin Single-Chain Antibody Fragments, Investigated with Mutants Engineered for Stability†

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

The intracellular antibody capture technology (IACT): towards a consensus sequence for intracellular antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Selection of antibodies for intracellular function using a two-hybrid in vivo system

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

A natural antibody missing a cysteine in VH: consequences for thermodynamic stability and folding.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Intrabody construction and expression. II. A synthetic catalytic Fv fragment

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Intrabody construction and expression. I. The critical role of VL domain stability

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

A semi-synthetic repertoire of intrinsically stable antibody fragments derived from a single-framework scaffold

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

The selection of intracellular antibodies.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Inhibition of Tat-mediated transactivation and HIV-1 replication by human anti-hCyclinT1 intrabodies

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Binding of intracellular anti-Rev single chain variable fragments to different epitopes of human immunodeficiency virus type 1 rev: variations in viral inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Intracellular antibody-caspase-mediated cell killing: an approach for application in cancer therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Harnessing the ubiquitination machinery to target the degradation of specific cellular proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Intracellular antibodies against HIV-1 envelope protein for AIDS gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Functional deletion of the CCR5 receptor by intracellular immunization produces cells that are refractory to CCR5-dependent HIV-1 infection and cell fusion

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Antineoplastic effect of anti-erbB-2 intrabody is not correlated with scFv affinity for its target

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Targeted tumor killing via an intracellular antibody against erbB-2.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Phenotypic knockout of the high-affinity human interleukin 2 receptor by intracellular single-chain antibodies against the alpha subunit of the receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Intrabody-mediated knockout of the high-affinity IL-2 receptor in primary human T cells using a bicistronic lentivirus vector

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Characterization of anti-cyclin E single-chain Fv antibodies and intrabodies in breast cancer cells: enhanced intracellular stability of novel sFv-F(c) intrabodies

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Generation and functional characterization of intracellular antibodies interacting with the kinase domain of human EGF receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Intracellular expression of anti-p21ras single chain Fv fragments inhibits meiotic maturation of xenopus oocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Restoration of transcriptional activity of p53 mutants in human tumour cells by intracellular expression of anti-p53 single chain Fv fragments

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Intrabody-mediated phenotypic knockout of major histocompatibility complex class I expression in human and monkey cell lines and in primary human keratinocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Protein transduction technology

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Ligand-targeted therapeutics in anticancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Therapeutic efficacy of anti-ErbB2 immunoliposomes targeted by a phage antibody selected for cellular endocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Antisense technology and prospects for therapy of viral infections and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

1 reference

7 January 2021

Expanding small RNA interference

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

RNA interference: advances and questions

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

A system for stable expression of short interfering RNAs in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Single domain intracellular antibodies: a minimal fragment for direct in vivo selection of antigen-specific intrabodies

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Inhibition of human immunodeficiency virus type 1 replication in vitro in acutely and persistently infected human CD4+ mononuclear cells expressing murine and humanized anti-human immunodeficiency virus type 1 Tat single-chain variable fragment intr

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Intracellular expression of antibody fragments directed against HIV reverse transcriptase prevents HIV infection in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Human recombinant antibody fragments neutralizing human immunodeficiency virus type 1 reverse transcriptase provide an experimental basis for the structural classification of the DNA polymerase family.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Intracellular immunization against HIV-1 infection of human T lymphocytes: utility of anti-rev single-chain variable fragments

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Intracellular immunization with cytosolic recombinant antibodies.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

IMGT, the international ImMunoGeneTics database: a high-quality information system for comparative immunogenetics and immunology

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900163-1

7 January 2021

10.1016/S1471-4914(03)00163-1

Identifiers

DOI

1 reference

7 August 2017

1 reference

PubMed ID

13129705