(Q35968447)

11 August 2017

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title

When sugars guide axons: insights from heparan sulphate proteoglycan mutants (English)

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11 August 2017

Jeong-Soo Lee

1

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11 August 2017

Chi-Bin Chien

series ordinal

2

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11 August 2017

publication date

1 December 2004

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11 August 2017

published in

Nature Reviews Genetics

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11 August 2017

volume

5

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11 August 2017

issue

12

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11 August 2017

page(s)

923-935

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The molecular biology of axon guidance

11 August 2017

cites work

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Molecular mechanisms of axon guidance

21 January 2018

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Signal transduction underlying growth cone guidance by diffusible factors

21 January 2018

1 reference

Dynamic regulation of axon guidance.

21 January 2018

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Signalling mechanisms mediating neuronal responses to guidance cues

21 January 2018

1 reference

The Drosophila Netrin receptor Frazzled guides axons by controlling Netrin distribution.

21 January 2018

1 reference

Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent slit during midline axon guidance.

21 January 2018

1 reference

Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex

21 January 2018

1 reference

The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons

21 January 2018

1 reference

Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation

21 January 2018

1 reference

Axonal protein synthesis provides a mechanism for localized regulation at an intermediate target

21 January 2018

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Axonal and presynaptic protein synthesis: new insights into the biology of the neuron

21 January 2018

1 reference

Comm sorts robo to control axon guidance at the Drosophila midline.

21 January 2018

1 reference

Functions of cell surface heparan sulfate proteoglycans

21 January 2018

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Heparan Sulfate Core Proteins in Cell-Cell Signaling

21 January 2018

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Order out of chaos: assembly of ligand binding sites in heparan sulfate

21 January 2018

1 reference

Conservation and divergence of axon guidance mechanisms.

21 January 2018

1 reference

Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance

21 January 2018

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Slit is the midline repellent for the robo receptor in Drosophila.

21 January 2018

1 reference

C. elegans slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor.

21 January 2018

1 reference

Slit2-Mediated chemorepulsion and collapse of developing forebrain axons

21 January 2018

1 reference

Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration

21 January 2018

1 reference

Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching

21 January 2018

1 reference

Involvement of Islet-2 in the Slit signaling for axonal branching and defasciculation of the sensory neurons in embryonic zebrafish

21 January 2018

1 reference

Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline

21 January 2018

1 reference

Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors

21 January 2018

1 reference

The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans.

21 January 2018

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Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord

21 January 2018

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Conserved roles for Slit and Robo proteins in midline commissural axon guidance

21 January 2018

1 reference

The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans

21 January 2018

1 reference

UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans

21 January 2018

1 reference

UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans

21 January 2018

1 reference

UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues

21 January 2018

1 reference

Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord

21 January 2018

1 reference

The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.

21 January 2018

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Deleted in Colorectal Cancer (DCC) encodes a netrin receptor

21 January 2018

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A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion

21 January 2018

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Short- and long-range repulsion by the Drosophila Unc5 netrin receptor.

21 January 2018

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Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases

21 January 2018

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In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases

21 January 2018

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Mechanisms and functions of Eph and ephrin signalling

21 January 2018

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Regulation of axial patterning of the retina and its topographic mapping in the brain.

21 January 2018

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Retinal axon response to ephrin-as shows a graded, concentration-dependent transition from growth promotion to inhibition

21 January 2018

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EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping

21 January 2018

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Topographic mapping in dorsoventral axis of the Xenopus retinotectal system depends on signaling through ephrin-B ligands

21 January 2018

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Bifunctional action of ephrin-B1 as a repellent and attractant to control bidirectional branch extension in dorsal-ventral retinotopic mapping

21 January 2018

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Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila

21 January 2018

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Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways

21 January 2018

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Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation

21 January 2018

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Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans

21 January 2018

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The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate

21 January 2018

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In vitro polymerization of heparan sulfate backbone by the EXT proteins

21 January 2018

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In vitro heparan sulfate polymerization: crucial roles of core protein moieties of primer substrates in addition to the EXT1-EXT2 interaction

21 January 2018

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The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate

21 January 2018

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Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice

21 January 2018

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Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis

21 January 2018

1 reference

21 January 2018

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The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension

21 January 2018

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The Caenorhabditis elegans sqv genes and functions of proteoglycans in development

21 January 2018

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Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification

21 January 2018

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Roles of heparan-sulphate glycosaminoglycans in cancer

21 January 2018

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Mammalian Brain Morphogenesis and Midline Axon Guidance Require Heparan Sulfate

21 January 2018

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Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

21 January 2018

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Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process.

21 January 2018

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FGFs, heparan sulfate and FGFRs: complex interactions essential for development

21 January 2018

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Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization

21 January 2018

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Clustering induces redistribution of syndecan-4 core protein into raft membrane domains

21 January 2018

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Heparan sulphate proteoglycans modulate fibroblast growth factor-2 binding through a lipid raft-mediated mechanism

21 January 2018

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Lipid rafts mediate chemotropic guidance of nerve growth cones

21 January 2018

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Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase sigma

21 January 2018

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Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons

21 January 2018

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Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain

21 January 2018

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Characterization of Slit protein interactions with glypican-1

21 January 2018

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Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 protein

21 January 2018

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Deleted in colorectal carcinoma (DCC) binds heparin via its fifth fibronectin type III domain

21 January 2018

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EphB/syndecan-2 signaling in dendritic spine morphogenesis

21 January 2018

1 reference

FGF signaling and target recognition in the developing Xenopus visual system

21 January 2018

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Inhibition of FGF receptor activity in retinal ganglion cell axons causes errors in target recognition

21 January 2018

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Heparan sulfate proteoglycan-dependent induction of axon branching and axon misrouting by the Kallmann syndrome gene kal-1.

21 January 2018

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Differential sulfations and epimerization define heparan sulfate specificity in nervous system development

21 January 2018

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EXT gene family member rib-2 is essential for embryonic development and heparan sulfate biosynthesis in Caenorhabditis elegans

21 January 2018

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An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

21 January 2018

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Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system

21 January 2018

1 reference

Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system

21 January 2018

1 reference

Pathfinding and error correction by retinal axons: the role of astray/robo2.

21 January 2018

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Generating X: formation of the optic chiasm

21 January 2018

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Embryonic fibroblasts with a gene trap mutation in Ext1 produce short heparan sulfate chains

21 January 2018

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Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline

21 January 2018

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Short-range and long-range guidance by Slit and its Robo receptors: a combinatorial code of Robo receptors controls lateral position

21 January 2018

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Selecting a longitudinal pathway: Robo receptors specify the lateral position of axons in the Drosophila CNS.

21 January 2018

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Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling

21 January 2018

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The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance

21 January 2018

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Syndecan-1 and -4 synthesized simultaneously by mouse mammary gland epithelial cells bear heparan sulfate chains that are apparently structurally indistinguishable

21 January 2018

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Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

21 January 2018

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Targeted disruption of NDST-1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice

21 January 2018

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Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1

21 January 2018

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Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme

21 January 2018

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Heparin is essential for the storage of specific granule proteases in mast cells

21 January 2018

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Mice deficient in heparan sulfate 3-O-sulfotransferase-1: Normal hemostasis with unexpected perinatal phenotypes

21 January 2018

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Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis

21 January 2018

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Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality

21 January 2018

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The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila

21 January 2018

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Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome

21 January 2018

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glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development

21 January 2018

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Defects in keratinocyte activation during wound healing in the syndecan-1-deficient mouse

21 January 2018

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Syndecan-3-deficient mice exhibit enhanced LTP and impaired hippocampus-dependent memory

21 January 2018

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UNC-52/perlecan affects gonadal leader cell migrations in C. elegans hermaphrodites through alterations in growth factor signaling

21 January 2018

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Perlecan is essential for cartilage and cephalic development

21 January 2018

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Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene.

21 January 2018

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Structural and functional mutations of the perlecan gene cause Schwartz-Jampel syndrome, with myotonic myopathy and chondrodysplasia

21 January 2018

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Perlecan maintains the integrity of cartilage and some basement membranes

21 January 2018

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Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney

21 January 2018

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Defective neuromuscular synaptogenesis in agrin-deficient mutant mice

21 January 2018

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The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins

21 January 2018

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astray, a zebrafish roundabout homolog required for retinal axon guidance

21 January 2018

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The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins

31 March 2020

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Proteoglycans in the developing brain: new conceptual insights for old proteins

31 March 2020

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Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signaling

31 March 2020

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Slit2 is a repellent for retinal ganglion cell axons

31 March 2020

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BMPs as mediators of roof plate repulsion of commissural neurons

31 March 2020

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Heparan sulfate chains from glypican and syndecans bind the Hep II domain of fibronectin similarly despite minor structural differences

31 March 2020

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Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase

31 March 2020

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Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice

31 March 2020

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Syndecan-4 deficiency impairs the fetal vessels in the placental labyrinth

31 March 2020

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Products of the unc-52 gene in Caenorhabditis elegans are homologous to the core protein of the mammalian basement membrane heparan sulfate proteoglycan

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG1490

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Dimensions Publication ID

11 August 2017

1052626661

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Fatcat ID

release_52qvkwzhc5ajxbyy4wg76usjj4

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Fatcat

https://api.fatcat.wiki/v0/release/52qvkwzhc5ajxbyy4wg76usjj4

mapped directly with Wikidata item

24 November 2022

based on heuristic

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