(Q35970805)

11 August 2017

Mass spectrometric characterization of a three-enzyme tandem reaction for assembly and modification of the novobiocin skeleton (English)

1 reference

3-dimethylallyl-4-hydroxybenzoic acid

11 August 2017

1 reference

3-amino-4,7-dihydroxy-8-methylcoumarin

ChEBI release 2020-05-28

ChEBI ID

31111

1 reference

3-dimethylallyl-4-hydroxybenzoate

ChEBI release 2020-05-28

ChEBI ID

74154

1 reference

ChEBI release 2020-05-28

0 references

5

Julie A Leary

1 reference

11 August 2017

4

Christopher T Walsh

1 reference

11 August 2017

Na Pi

1

1 reference

11 August 2017

Caren L Freel Meyers

series ordinal

2

1 reference

11 August 2017

Michelle Pacholec

series ordinal

3

1 reference

11 August 2017

language of work or name

English

0 references

publication date

24 June 2004

1 reference

Proceedings of the National Academy of Sciences of the United States of America

11 August 2017

1 reference

11 August 2017

101

1 reference

11 August 2017

27

1 reference

11 August 2017

10036-10041

1 reference

Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

Multiplex inhibitor screening and kinetic constant determinations for yeast hexokinase using mass spectrometry based assays

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

Investigation of enzyme kinetics using quench-flow techniques with MALDI-TOF mass spectrometry

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

Cloning, overexpression, and purification of novobiocic acid synthetase from Streptomyces spheroides NCIMB 11891.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

The additional 165 amino acids in the B protein of Escherichia coli DNA gyrase have an important role in DNA binding

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

Synthesis and biological evaluation of coumarincarboxylic acids as inhibitors of gyrase B. L-rhamnose as an effective substitute for L-noviose

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

DNA gyrase as a drug target

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

Methicillin-resistant Staphylococcus aureus: the persistent resistant nosocomial pathogen.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

The effect of bacterial DNA gyrase inhibitors on DNA synthesis in mammalian mitochondria

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

Effects of novobiocin, coumermycin A1, clorobiocin, and their analogs on Escherichia coli DNA gyrase and bacterial growth

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

Crystal structure of an N-terminal fragment of the DNA gyrase B protein.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

Three-dimensional model of Escherichia coli gyrase B subunit crystallized in two-dimensions on novobiocin-linked phospholipid films.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

Effect of novobiocin on DNA-dependent DNA polymerases from developing rat brain

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

Novobiocin inhibition of DNA excision repair may occur through effects on mitochondrial structure and ATP metabolism, not on repair topoisomerases.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

Coumarins as inhibitors of bacterial DNA gyrase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=454160

Synthesis and in vitro evaluation of novel highly potent coumarin inhibitors of gyrase B.

11 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403526101

A strategy for the determination of enzyme kinetics using electrospray ionization with an ion trap mass spectrometer

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403526101

Kinetic measurements of phosphoglucomutase by direct analysis of glucose-1-phosphate and glucose-6-phosphate using ion/molecule reactions and Fourier transform ion cyclotron resonance mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403526101

Kinetic analysis of NodST sulfotransferase using an electrospray ionization mass spectrometry assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403526101

Observation of a hybrid random ping-pong mechanism of catalysis for NodST: a mass spectrometry approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403526101

Determination of enzyme/substrate specificity constants using a multiple substrate ESI-MS assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403526101

Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403526101

Probing the Binding of Coumarins and Cyclothialidines to DNA Gyrase†

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0403526101

Kinetic monitoring of enzymatic reactions in real time by quantitative high-performance liquid chromatography-mass spectrometry

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15218104

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Interaction of Coumarin Antibiotics with Fragments of the DNA Gyrase B Protein†

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15218104

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0403526101

1 reference

11 August 2017

0 references

1 reference

11 August 2017

PubMed publication ID

15218104

1 reference