(Q35981296)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27050763%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

title

Interleukin 6 Accelerates Mortality by Promoting the Progression of the Systemic Lupus Erythematosus-Like Disease of BXSB.Yaa Mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27050763%20AND%20SRC:MED&resulttype=core&format=json

systemic lupus erythematosus

31 March 2020

main subject

0 references

author

Shweta Jain

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27050763%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

author name string

Giljun Park

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27050763%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Thomas J Sproule

3

1 reference

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31 March 2020

Gregory J Christianson

4

1 reference

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31 March 2020

Caroline M Leeth

5

1 reference

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31 March 2020

Hongsheng Wang

6

1 reference

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31 March 2020

Derry C Roopenian

7

1 reference

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31 March 2020

Herbert C Morse

8

1 reference

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31 March 2020

language of work or name

English

0 references

publication date

6 April 2016

1 reference

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31 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27050763%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

volume

11

1 reference

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31 March 2020

issue

4

1 reference

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31 March 2020

page(s)

e0153059

1 reference

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Creative Commons CC0 License

31 March 2020

copyright license

start time

6 April 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

cites work

IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice

1 reference

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A meta-analysis of the association of IL-6 -174 G/C and -572 G/C polymorphisms with systemic lupus erythematosus risk

2 October 2017

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Phase I, randomized, double-blind, placebo-controlled, multiple intravenous, dose-ascending study of sirukumab in cutaneous or systemic lupus erythematosus.

2 October 2017

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Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation

2 October 2017

1 reference

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2 October 2017

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IL-6 triggers IL-21 production by human CD4+ T cells to drive STAT3-dependent plasma cell differentiation in B cells

2 October 2017

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MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis

2 October 2017

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IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation

2 October 2017

1 reference

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Follicular helper CD4 T cells (TFH)

2 October 2017

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The type I interferon system in the development of lupus

2 October 2017

1 reference

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Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus

2 October 2017

1 reference

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In vivo regulation of Bcl6 and T follicular helper cell development

2 October 2017

1 reference

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Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study

2 October 2017

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Toll-like receptors--sentries in the B-cell response

2 October 2017

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B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion.

2 October 2017

1 reference

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Bcl6 mediates the development of T follicular helper cells

2 October 2017

1 reference

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A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4822786

The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4822786

Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities

2 October 2017

1 reference

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Yaa autoimmune phenotypes are conferred by overexpression of TLR7.

2 October 2017

1 reference

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Development and characterization of IL-21-producing CD4+ T cells

2 October 2017

1 reference

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TLR7 and CD40 cooperate in IL-6 production via enhanced JNK and AP-1 activation.

2 October 2017

1 reference

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Nucleic acid recognizing Toll-like receptors and autoimmunity

2 October 2017

1 reference

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Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation

2 October 2017

1 reference

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A Tlr7 translocation accelerates systemic autoimmunity in murine lupus

2 October 2017

1 reference

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Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication

2 October 2017

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RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

2 October 2017

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Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction

2 October 2017

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Microarray analysis of interferon-regulated genes in SLE.

2 October 2017

1 reference

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Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice

2 October 2017

1 reference

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Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

2 October 2017

1 reference

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Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2 October 2017

1 reference

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Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

2 October 2017

1 reference

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The immune response modifier resiquimod mimics CD40-induced B cell activation

2 October 2017

1 reference

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Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristane-induced lupus

2 October 2017

1 reference

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Interleukin 6 promotes murine lupus in NZB/NZW F1 mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4822786

Functional role of type I and type II interferons in antiviral defense

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4822786

Monocytosis in the BXSB model for systemic lupus erythematosus

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4822786

Heterogeneity of B cell responsiveness to interleukin 4, interleukin 6 and low molecular weight B cell growth factor in discrete stages of B cell activation in patients with systemic lupus erythematosus

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4822786

A y chromosome associated factor in strain bxsb producing accelerated autoimmunity and lymphoproliferation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4822786

Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4822786

Possible role of IL-6 in pathogenesis of immune complex-mediated glomerulonephritis in NZB/W F1 mice: induction of IgG class anti-DNA autoantibody production.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4822786

Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4822786

In vitro regulation of B cell differentiation by interleukin-6 and soluble CD23 in systemic lupus erythematosus B cell subpopulations and antigen-induced normal B cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4822786

Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4822786

Toll-like receptor 7-induced naive human B-cell differentiation and immunoglobulin production

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4822786

Type I IFN receptor signals directly stimulate local B cells early following influenza virus infection

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4822786

Cytokine production, serum levels and disease activity in systemic lupus erythematosus

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4822786

Macrophage depletion decreases IgG anti-DNA in cultures from (NZB · NZW)F1 spleen cells by eliminating the main source of IL-6

24 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0153059

IFN-alpha/beta enhances BCR-dependent B cell responses

21 January 2018

1 reference

12 December 2020

The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells

1 reference

12 December 2020

An autosomal recessive gene that delays expression of lupus in BXSB mice

1 reference

12 December 2020

Age-associated increase in interleukin 6 in MRL/lpr mice

1 reference

12 December 2020

Abnormal distribution of IL-6 receptor in aged MRL/lpr mice: elevated expression on B cells and absence on CD4+ cells

1 reference

12 December 2020

Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal

1 reference

12 December 2020

Constitutive expression of IL-6 receptors and their role in the excessive B cell function in patients with systemic lupus erythematosus

1 reference

12 December 2020

TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses

1 reference

12 December 2020

Monocytosis in BXSB mice is due to epistasis between Yaa and the telomeric region of chromosome 1 but does not drive the disease process

1 reference

12 December 2020

Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0153059

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27050763%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27050763%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27050763%20AND%20SRC:MED&resulttype=core&format=json