(Q35986039)

11 August 2017

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title

Natural and engineered nucleic acids as tools to explore biology (English)

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11 August 2017

1

1 reference

11 August 2017

language of work or name

English

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publication date

1 December 2004

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11 August 2017

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11 August 2017

volume

432

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11 August 2017

issue

7019

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11 August 2017

page(s)

838-845

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Directed evolution of proteins by exon shuffling

11 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Directed evolution of enzymes and pathways for industrial biocatalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Directed evolution of nucleic acid enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

In vitro selection of functional nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

RNA polymerase II accumulation in the promoter-proximal region of the dihydrofolate reductase and gamma-actin genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

The structural basis of ribosome activity in peptide bond synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

RNA, the first macromolecular catalyst: the ribosome is a ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Progress in antisense technology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Applying antisense technology: Affinitak and other antisense oligonucleotides in clinical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Mechanisms of gene silencing by double-stranded RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

21 January 2018

Ribonucleosides and RNA.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Designing anti-AIDS drugs targeting the major mechanism of HIV-1 RT resistance to nucleoside analog drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Allosteric selection of ribozymes that respond to the second messengers cGMP and cAMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Generating new ligand-binding RNAs by affinity maturation and disintegration of allosteric ribozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

In vitro evolution of RNA aptamers recognizing carcinogenic aromatic amines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Retention and separation of adenosine and analogues by affinity chromatography with an aptamer stationary phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Adaptive recognition by nucleic acid aptamers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Aptamer beacons for the direct detection of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Aptamer-based biosensor arrays for detection and quantification of biological macromolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Prospects for antiviral ribozymes and deoxyribozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

In vitro selection of a novel nuclease-resistant RNA phosphodiesterase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

In vivo-applied functional RNAs as tools in proteomics and genomics research

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Spiegelmers: Biostable Aptamers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Mirror-image RNA that binds D-adenosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Automated selection of anti-protein aptamers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Automated acquisition of aptamer sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Automated selection of aptamers against protein targets translated in vitro: from gene to aptamer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

RNA aptamers as reversible antagonists of coagulation factor IXa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

The structures of four macrolide antibiotics bound to the large ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Inhibition of viral gene expression by human ribonuclease P.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Effective inhibition of influenza virus production in cultured cells by external guide sequences and ribonuclease P.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Efficient and specific repair of sickle beta-globin RNA by trans-splicing ribozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Emerging clinical applications of RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Use of computer-designed group II introns to disrupt Escherichia coli DExH/D-box protein and DNA helicase genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Ribozymes as tools for therapeutic target validation in arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

RNA-catalysed nucleotide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

A ribozyme that ligates RNA to protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Structural diversity of self-cleaving ribozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Substrate specificity and reaction kinetics of an X-motif ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Deoxyribozymes: new activities and new applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

A general purpose RNA-cleaving DNA enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Mechanism and utility of an RNA-cleaving DNA enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Nucleic acid based strategies as potential therapeutic tools: mechanistic considerations and implications to restenosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Phosphorylating DNA with DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Sequence diversity, metal specificity, and catalytic proficiency of metal-dependent phosphorylating DNA enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

21 January 2018

Ligating DNA with DNA.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Structural basis of RNA folding and recognition in an AMP-RNA aptamer complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Relationship between internucleotide linkage geometry and the stability of RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Rational design of allosteric ribozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Engineered allosteric ribozymes as biosensor components

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Rube Goldberg goes (ribo)nuclear? Molecular switches and sensors made from RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Immobilized RNA switches for the analysis of complex chemical and biological mixtures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Zeptomole detection of a viral nucleic acid using a target-activated ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

ADP-specific sensors enable universal assay of protein kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

A novel strategy for selection of allosteric ribozymes yields RiboReporter sensors for caffeine and aspartame

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Sensing complex regulatory networks by conformationally controlled hairpin ribozymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Protein-dependent ribozymes report molecular interactions in real time.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Gene regulation by riboswitches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Genetic control by a metabolite binding mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Adenine riboswitches and gene activation by disruption of a transcription terminator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Definition of a second Bacillus subtilis pur regulon comprising the pur and xpt-pbuX operons plus pbuG, nupG (yxjA), and pbuE (ydhL).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Controlling gene expression in living cells through small molecule-RNA interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Inducible regulation of the S. cerevisiae cell cycle mediated by an RNA aptamer-ligand complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Inhibition of translation by RNA-small molecule interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Conditional gene expression by controlling translation with tetracycline-binding aptamers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Tetracycline-aptamer-mediated translational regulation in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

A theophylline responsive riboswitch based on helix slipping controls gene expression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Metabolite-binding RNA domains are present in the genes of eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

An mRNA structure in bacteria that controls gene expression by binding lysine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Control of gene expression by a natural metabolite-responsive ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Identification of genes by hybrid ribozymes that couple cleavage activity with the unwinding activity of an endogenous RNA helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Inverse Genomics as a powerful tool to identify novel targets for the treatment of neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Ribozyme-mediated revision of RNA and DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Alternative splicing in disease and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

The mechanism of intrinsic transcription termination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Sequence-specific modification of genomic DNA by small DNA fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

In vitro evolution of a self-alkylatlng ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

A small catalytic oligoribonucleotide

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

Diversity of oligonucleotide functions

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

Nucleic Acid Selection and the Challenge of Combinatorial Chemistry

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

Structural determinants of conformationally selective, prion-binding aptamers.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

In vitro selection of signaling aptamers

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

Nucleic-acid therapeutics: basic principles and recent applications

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

Modified RNA sequence pools for in vitro selection

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

Regulating eukaryotic gene expression with aptamers.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

Uptake and intracellular transport of RNA aptamers in African trypanosomes suggest therapeutic "piggy-back" approach

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

Mirror-design of L-oligonucleotide ligands binding to L-arginine

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

Anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

Aptamer inhibits degradation of platelet proteolytically activatable receptor, PAR-1, by thrombin

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

Ribozymes in the age of molecular therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

Simultaneous detection of diverse analytes with an aptazyme ligase array

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

High-throughput ribozyme-based assays for detection of viral nucleic acids

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

Sequence-specific modification of genomic DNA by small DNA fragments

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

Viral vectors for gene transfer: a review of their use in the treatment of human diseases

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

Mechanism of intrinsic transcription termination and antitermination

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03195

7 January 2021

Identifiers

DOI

10.1038/NATURE03195

1 reference

11 August 2017

1 reference