(Q35989027)

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Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation

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scholarly article

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Europe PubMed Central

PMC publication ID

11 August 2017

Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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Unni Cecilie Nygaard

3

object named as

Unni Cecilie Nygaard

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

object named as

Ha Thi Ngo

1

0 references

Inger-Lise Steffensen

object named as

Inger-Lise Steffensen

4

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author name string

Ragna Bogen Hetland

2

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

publication date

10 August 2015

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Journal of Obesity

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Europe PubMed Central

PMC publication ID

11 August 2017

2015

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

343479

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

copyright license

Creative Commons Attribution 3.0 Unported

1 January 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

1 reference

April 2022 Public Data File from Crossref

Secondary bile acids: an underrecognized cause of colon cancer

1 reference

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2 October 2017

Effect of diet on expression of genes involved in lipid metabolism, oxidative stress, and inflammation in mouse liver-insights into mechanisms of hepatic steatosis

1 reference

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2 October 2017

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1 reference

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2 October 2017

Meta-review of protein network regulating obesity between validated obesity candidate genes in the white adipose tissue of high-fat diet-induced obese C57BL/6J mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

An APC:WNT Counter-Current-Like Mechanism Regulates Cell Division Along the Human Colonic Crypt Axis: A Mechanism That Explains How APC Mutations Induce Proliferative Abnormalities That Drive Colon Cancer Development

1 reference

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2 October 2017

Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis.

1 reference

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2 October 2017

Adipokines mediate inflammation and insulin resistance

1 reference

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2 October 2017

Linking obesity to colorectal cancer: recent insights into plausible biological mechanisms

1 reference

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2 October 2017

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1 reference

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2 October 2017

Leptin signaling and leptin resistance

1 reference

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2 October 2017

The role of leptin in the control of insulin-glucose axis

1 reference

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2 October 2017

Molecular mechanisms of central leptin resistance in obesity

1 reference

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2 October 2017

Molecular pathways in colorectal cancer.

1 reference

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2 October 2017

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1 reference

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2 October 2017

Targeting the insulin-like growth factor axis for the development of novel therapeutics in oncology

1 reference

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2 October 2017

C57BL/KsJ-db/db-Apc mice exhibit an increased incidence of intestinal neoplasms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Molecular mechanisms of cancer development in obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Intestinal inflammatory cytokine response in relation to tumorigenesis in the Apc(Min/+) mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Phospholipase D meets Wnt signaling: a new target for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Role of obesity-associated dysfunctional adipose tissue in cancer: a molecular nutrition approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Dietary insulin load, dietary insulin index, and colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Insulin resistance and hyperinsulinaemia in the development and progression of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Saturated with fat: new perspectives on lipotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Insulin and insulin-like growth factor signalling in neoplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Wnt signaling: relevance to beta-cell biology and diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Development of aberrant crypt foci in the colons of ob/ob and db/db mice: evidence that leptin is not a promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Leptin deficiency per se dictates body composition and insulin action in ob/ob mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Obesity, Inflammation, and Insulin Resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Changes in gene expression foreshadow diet-induced obesity in genetically identical mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Obese, a new mutation in the house mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

The use of animal models to dissect the biology of leptin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Leptin resistance - or why leptin fails to work in obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Regulation of Wnt signaling during adipogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Inhibition of adipogenesis by Wnt signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Neonatal exposure to the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine via breast milk or directly induces intestinal tumors in multiple intestinal neoplasia mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Leptin and the regulation of body weight in mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Heterozygosity for Lep(ob) or Lep(rdb) affects body composition and leptin homeostasis in adult mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Positional cloning of the mouse obese gene and its human homologue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

2 October 2017

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine increases the numbers of tumors, cystic crypts and aberrant crypt foci in multiple intestinal neoplasia mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

27 July 2018

In utero exposure to perfluorooctanoate (PFOA) or perfluorooctane sulfonate (PFOS) did not increase body weight or intestinal tumorigenesis in multiple intestinal neoplasia (Min/+) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

RETRACTED: Obesity-induced increase in tumor necrosis factor-α leads to development of colon cancer in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

Diet-induced obesity elevates colonic TNF-α in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

Measured body mass index in adolescence and the incidence of colorectal cancer in a cohort of 1.1 million males

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

A prospective study of body mass index, weight change, and risk of cancer in the proximal and distal colon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

Inflammation does not precede or accompany the induction of preneoplastic lesions in the colon of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-fed rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

Obesity enhances gastrointestinal tumorigenesis in Apc-mutant mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

Insulin resistance, apoptosis, and colorectal adenoma risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

Effect of sex and age on serum biochemical reference ranges in C57BL/6J mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

Leptin reduces the development of the initial precancerous lesions induced by azoxymethane in the rat colonic mucosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

Differential effects of leptin on cancer in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

Intestinal tumorigenesis in multiple intestinal neoplasia mice induced by the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine: perinatal susceptibility, regional variation, and correlation with DNA adducts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

Partial leptin deficiency and human adiposity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

Lipid metabolism and APC: implications for colorectal cancer prevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4546984

24 September 2018

Obesity, energy balance, and cancer: a mechanistic perspective

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F343479

21 January 2018

Tumor suppressor gene adenomatous polyposis coli downregulates intestinal transport

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F343479

21 January 2018

Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26347815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular genetics of colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/26347815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary fat intake and cancer risk: a controversial and instructive story

1 reference

https://pubmed.ncbi.nlm.nih.gov/26347815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1155/2015/343479

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

ResearchGate publication ID

0 references

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