(Q36014997)

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Human Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1.

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Europe PubMed Central

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29 January 2020

Human Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1 (English)

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29 January 2020

Grégoire Altan-Bonnet

12

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29 January 2020

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Emanuela Romano

1

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29 January 2020

Jesse W Cotari

2

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29 January 2020

Rosa Barreira da Silva

3

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29 January 2020

Brian C Betts

4

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29 January 2020

David J Chung

5

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29 January 2020

Francesca Avogadri

6

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29 January 2020

Mitsu J Fink

7

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29 January 2020

Erin T St Angelo

8

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29 January 2020

Babak Mehrara

9

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29 January 2020

Glenn Heller

10

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29 January 2020

Christian Münz

11

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29 January 2020

James W Young

13

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29 January 2020

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17 April 2012

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29 January 2020

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29 January 2020

119

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29 January 2020

22

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29 January 2020

5182-5190

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29 January 2020

describes a project that uses

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11 June 2022

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Peptide-loaded Langerhans cells, despite increased IL15 secretion and T-cell activation in vitro, elicit antitumor T-cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo.

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IL-15-induced human DC efficiently prime melanoma-specific naive CD8+ T cells to differentiate into CTL.

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Identifiers

10.1182/BLOOD-2011-09-382200

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29 January 2020

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29 January 2020

1 reference

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29 January 2020

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