(Q36016920)

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Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22505716%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins (English)

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29 January 2020

neurodegeneration

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6

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29 January 2020

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Jin Zheng

1

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29 January 2020

Hirotaka Watanabe

2

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29 January 2020

Mary Wines-Samuelson

3

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29 January 2020

Huailong Zhao

4

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29 January 2020

Thomas Gridley

5

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29 January 2020

Jie Shen

7

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29 January 2020

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13 April 2012

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29 January 2020

number of pages

13

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Journal of Biological Chemistry

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29 January 2020

287

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29 January 2020

24

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29 January 2020

20356-20368

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Europe PubMed Central

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29 January 2020

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3370217/fullTextXML

based on heuristic

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Presenilins in synaptic function and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

The many substrates of presenilin/γ-secretase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Presenilin controls CBP levels in the adult Drosophila central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

CREB binding protein is required for both short-term and long-term memory formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Presenilins are essential for regulating neurotransmitter release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

The canonical Notch signaling pathway: unfolding the activation mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Indirect regulation of presenilins in CREB-mediated transcription.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Presenilins are required for maintenance of neural stem cells in the developing brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

MAPK regulation of maternal and zygotic Notch transcript stability in early development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Notch signalling regulates stem cell numbers in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Notch-1 activation and dendritic atrophy in prion disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Induction of gp130-related Cytokines and Activation of JAK2/STAT3 Pathway in Astrocytes Precedes Up-regulation of Glial Fibrillary Acidic Protein in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Radial glial identity is promoted by Notch1 signaling in the murine forebrain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Notch signaling is essential for vascular morphogenesis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Presenilin-1 regulates neuronal differentiation during neurogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Nuclear Notch1 signaling and the regulation of dendritic development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Activity-dependent regulation of synaptic clustering in a hippocampal culture system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Control of memory formation through regulated expression of a CaMKII transgene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Notch1 is required for the coordinate segmentation of somites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

2 October 2017

RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

11 July 2018

A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

11 July 2018

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

11 July 2018

Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

11 July 2018

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

11 July 2018

Notch1 is essential for postimplantation development in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

11 July 2018

Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.349738

21 January 2018

Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.349738

21 January 2018

Essential roles of Notch signaling in maintenance of neural stem cells in developing and adult brains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.349738

21 January 2018

Differential Notch signalling distinguishes neural stem cells from intermediate progenitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.349738

21 January 2018

Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.349738

21 January 2018

Notch-1 immunoexpression is increased in Alzheimer's and Pick's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.349738

21 January 2018

Gamma-secretase: proteasome of the membrane?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.349738

21 January 2018

Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.349738

21 January 2018

Differential expression of Notch1 and Notch2 in developing and adult mouse brain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.349738

21 January 2018

Generation of new Notch2 mutant alleles.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.349738

21 January 2018

Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.349738

21 January 2018

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.349738

21 January 2018

Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.349738

21 January 2018

Mouse Notch 3 expression in the pre- and postnatal brain: relationship to the stroke and dementia syndrome CADASIL.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.349738

21 January 2018

Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

23 September 2018

The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

23 September 2018

Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370217

23 September 2018

Contact-dependent inhibition of cortical neurite growth mediated by notch signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/22505716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

https://pubmed.ncbi.nlm.nih.gov/22505716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.349738

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22505716%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22505716%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22505716%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

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