(Q36021597)

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Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.

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scholarly article

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31 January 2020

Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions (English)

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31 January 2020

Kenneth A. Jacobson

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31 January 2020

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Zhan-Guo Gao

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31 January 2020

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Dilip K Tosh

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31 January 2020

Elizabeth T Gizewski

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Elizabeth Gizewski

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31 January 2020

John A Auchampach

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John A Auchampach

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31 January 2020

Francesca Deflorian

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Francesca Deflorian

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31 January 2020

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Tina C Wan

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31 January 2020

author name string

Khai Phan

3

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31 January 2020

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16 May 2012

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31 January 2020

Journal of Medicinal Chemistry

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31 January 2020

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31 January 2020

10

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31 January 2020

4847-4860

1 reference

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31 January 2020

G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions

1 reference

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2 October 2017

Controlling murine and rat chronic pain through A3 adenosine receptor activation

1 reference

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2 October 2017

Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor

1 reference

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2 October 2017

The A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches

1 reference

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2 October 2017

Pharmacological and therapeutic effects of A3 adenosine receptor agonists

1 reference

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2 October 2017

Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition Element

1 reference

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2 October 2017

Increased neutrophil adenosine a3 receptor expression is associated with hemorrhagic shock and injury severity in trauma patients

1 reference

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2 October 2017

Crystal structure of the β2 adrenergic receptor-Gs protein complex

1 reference

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2 October 2017

Progress in structure based drug design for G protein-coupled receptors

1 reference

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2 October 2017

Structure of an agonist-bound human A2A adenosine receptor

1 reference

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2 October 2017

Systematic investigation of halogen bonding in protein-ligand interactions

1 reference

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2 October 2017

Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues.

1 reference

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2 October 2017

Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371665

2 October 2017

Evaluation of homology modeling of G-protein-coupled receptors in light of the A(2A) adenosine receptor crystallographic structure.

1 reference

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2 October 2017

Synthesis and characterization of [76Br]-labeled high-affinity A3 adenosine receptor ligands for positron emission tomography

1 reference

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2 October 2017

Crystal structure of opsin in its G-protein-interacting conformation

1 reference

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2 October 2017

The A3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-kappaB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats

1 reference

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2 October 2017

A2A adenosine receptor and its modulators: overview on a druggable GPCR and on structure-activity relationship analysis and binding requirements of agonists and antagonists

1 reference

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2 October 2017

Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells

1 reference

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2 October 2017

Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371665

2 October 2017

Clinical evidence for utilization of the A3 adenosine receptor as a target to treat rheumatoid arthritis: data from a phase II clinical trial

1 reference

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2 October 2017

The A3 adenosine receptor: an enigmatic player in cell biology

1 reference

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2 October 2017

The A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channel

1 reference

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2 October 2017

The Sonogashira reaction: a booming methodology in synthetic organic chemistry.

1 reference

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2 October 2017

2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371665

2 October 2017

Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor

1 reference

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2 October 2017

Ligand-based homology modeling as attractive tool to inspect GPCR structural plasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371665

2 October 2017

A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion

1 reference

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2 October 2017

Novel procedure for modeling ligand/receptor induced fit effects.

1 reference

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2 October 2017

Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371665

2 October 2017

The cross-species A3 adenosine-receptor antagonist MRS 1292 inhibits adenosine-triggered human nonpigmented ciliary epithelial cell fluid release and reduces mouse intraocular pressure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371665

2 October 2017

(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371665

2 October 2017

Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371665

2 October 2017

Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371665

2 October 2017

Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists

1 reference

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2 October 2017

Pharmacological characterization of novel A3 adenosine receptor-selective antagonists

1 reference

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2 October 2017

125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor

1 reference

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2 October 2017

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

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2 October 2017

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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2 October 2017

Quantifying the chemical beauty of drugs.

1 reference

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11 July 2018

Molecular modeling study on potent and selective adenosine A(3) receptor agonists.

1 reference

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11 July 2018

[3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain

1 reference

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11 July 2018

Analysis of adenosine A₂a receptor stability: effects of ligands and disulfide bonds.

1 reference

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23 September 2018

Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor

1 reference

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23 September 2018

Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury

1 reference

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23 September 2018

N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor.

1 reference

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23 September 2018

ADOA3R as a therapeutic target in experimental colitis: proof by validated high-density oligonucleotide microarray analysis.

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23 September 2018

The synthesis of highly potent, selective, and water-soluble agonists at the human adenosine A3 receptor

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23 September 2018

Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor

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23 September 2018

Generation of adenosine A3 receptor functionally humanized mice for the evaluation of the human antagonists

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23 September 2018

2-Pyrazolyl-N(6)-substituted adenosine derivatives as high affinity and selective adenosine A(3) receptor agonists

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23 September 2018

Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary

1 reference

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23 September 2018

Effector coupling of stably transfected human A3 adenosine receptors in CHO cells

1 reference

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The three binding domain model of adenosine receptors: molecular modeling aspects

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine receptors in colon carcinoma tissues and colon tumoral cell lines: focus on the A(3) adenosine subtype

1 reference

https://pubmed.ncbi.nlm.nih.gov/22559880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of adenosine receptors in rat brain by (?)[3H]N6-phenylisopropyladenosine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22559880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A modification of a protein-binding method for rapid quantification of cAMP in cell-culture supernatants and body fluid

1 reference

https://pubmed.ncbi.nlm.nih.gov/22559880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM300396N

1 reference

Europe PubMed Central

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31 January 2020

1 reference

Europe PubMed Central

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31 January 2020

1 reference

Europe PubMed Central

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31 January 2020

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