(Q36027399)

11 August 2017

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title

Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptor ubiquitylation (English)

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11 August 2017

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Chanan Rubin

1

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11 August 2017

Gal Gur

series ordinal

2

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11 August 2017

Yosef Yarden

series ordinal

3

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11 August 2017

language of work or name

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1 January 2005

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11 August 2017

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11 August 2017

15

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11 August 2017

1

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11 August 2017

66-71

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https://scigraph.springernature.com/pub.10.1038/sj.cr.7290268

11 August 2017

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Oncogenic kinase signalling

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7 January 2021

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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7 January 2021

Signaling by the Drosophila epidermal growth factor receptor pathway during development

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7 January 2021

Sprouty, an intracellular inhibitor of Ras signaling.

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https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

The Drosophila kekkon genes: novel members of both the leucine-rich repeat and immunoglobulin superfamilies expressed in the CNS.

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https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control

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https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Promotion and attenuation of FGF signaling through the Ras-MAPK pathway

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https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

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https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Cbl: many adaptations to regulate protein tyrosine kinases

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https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

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https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Receptor downregulation and multivesicular-body sorting

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases

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https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops

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https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways

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7 January 2021

Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells

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https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis.

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https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

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https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

mSprouty2 inhibits FGF10-activated MAP kinase by differentially binding to upstream target proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Evidence for direct interaction between Sprouty and Cbl

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Beyond the RING: CBL proteins as multivalent adapters

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Bipartite inhibition of Drosophila epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Comparative analysis of the Kekkon molecules, related members of the LIG superfamily

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Characterization and tissue-specific expression of human LRIG2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Cloning, characterization, and expression of human LIG1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Sef is a spatial regulator for Ras/MAP kinase signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Senseless represses nuclear transduction of Egfr pathway activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Spred is a Sprouty-related suppressor of Ras signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290268

7 January 2021

Identifiers

DOI

10.1038/SJ.CR.7290268

1 reference

11 August 2017

1 reference