(Q36036947)

11 August 2017

Paeonia lactiflora Pall. protects against ANIT-induced cholestasis by activating Nrf2 via PI3K/Akt signaling pathway (English)

1 reference

[(1S,3R,5R,6R,8S)-6-hydroxy-8-methyl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9,10-dioxatetracyclo[4.3.1.02,5.03,8]decan-2-yl]methyl 4-hydroxybenzoate

11 August 2017

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ChEBI release 2020-05-28

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1 reference

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1 reference

1 reference

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1 reference

Xiao Ma

1

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11 August 2017

Yan-ling Zhao

2

1 reference

11 August 2017

Yun Zhu

3

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11 August 2017

Zhe Chen

4

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11 August 2017

Jia-bo Wang

5

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11 August 2017

Rui-yu Li

6

1 reference

11 August 2017

Chang Chen

7

1 reference

11 August 2017

Shi-zhang Wei

8

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11 August 2017

Jian-yu Li

9

1 reference

11 August 2017

Bing Liu

10

1 reference

11 August 2017

Rui-lin Wang

11

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11 August 2017

Yong-gang Li

12

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11 August 2017

Li-fu Wang

13

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11 August 2017

Xiao-he Xiao

14

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11 August 2017

language of work or name

English

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publication date

2 September 2015

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full work available at URL

11 August 2017

https://www.dovepress.com/getfile.php?fileID=26854

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.2147/dddt.s90030?email=unpaywall_01@example.com

published in

Drug Design, Development and Therapy

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11 August 2017

9

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11 August 2017

5061-5074

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Creative Commons Attribution-NonCommercial 3.0 Unported

11 August 2017

start time

1 September 2015

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April 2022 Public Data File from Crossref

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1 reference

19 March 2024

https://api.unpaywall.org/v2/10.2147/dddt.s90030?email=unpaywall_01@example.com

access restriction status

open access

1 reference

inferred from online access status

cites work

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Large dose means significant effect--dose and effect relationship of Chi-Dan-Tui-Huang decoction on alpha-naphthylisothiocyanate-induced cholestatic hepatitis in rats

2 October 2017

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Rosuvastatin suppresses atrial tachycardia-induced cellular remodeling via Akt/Nrf2/heme oxygenase-1 pathway

2 October 2017

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Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway

2 October 2017

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The Protective Effect of Beraprost Sodium on Diabetic Cardiomyopathy through the Inhibition of the p38 MAPK Signaling Pathway in High-Fat-Induced SD Rats

2 October 2017

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Resveratrol effectively attenuates α-naphthyl-isothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms

2 October 2017

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Large dosage of chishao in formulae for cholestatic hepatitis: a systematic review and meta-analysis

2 October 2017

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Role of protein kinase C isoforms in bile formation and cholestasis

2 October 2017

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Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice

2 October 2017

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Identification of NF-κB Inhibitors in Xuebijing injection for sepsis treatment based on bioactivity-integrated UPLC-Q/TOF.

2 October 2017

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Mapping small molecule binding data to structural domains

2 October 2017

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Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats.

2 October 2017

1 reference

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Anti-inflammatory and immunomodulatory effects of paeonia lactiflora pall., a traditional chinese herbal medicine.

2 October 2017

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TCM Database@Taiwan: the world's largest traditional Chinese medicine database for drug screening in silico

2 October 2017

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HIT: linking herbal active ingredients to targets

2 October 2017

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Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.

2 October 2017

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ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562737

Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells

2 October 2017

1 reference

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Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice.

2 October 2017

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Regulation of glutathione synthesis

2 October 2017

1 reference

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Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis.

2 October 2017

1 reference

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An HPLC/MS method for identifying major constituents in the hypocholesterolemic extracts of Chinese medicine formula 'Xue-Fu-Zhu-Yu decoction'.

2 October 2017

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Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants

2 October 2017

1 reference

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Vitamin A supplementation alleviates extrahepatic cholestasis liver injury through Nrf2 activation

2 October 2017

1 reference

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Dysregulation of glutathione synthesis during cholestasis in mice: molecular mechanisms and therapeutic implications

11 July 2018

1 reference

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Comparisons of the pharmacokinetic profile of four bioactive components after oral administration of gan-sui-ban-xia decoction plus-minus gansui and gancao drug combination in normal rats.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562737

Paeoniflorin protects against concanavalin A-induced hepatitis in mice.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562737

Paeoniflorin inhibition of 6-hydroxydopamine-induced apoptosis in PC12 cells via suppressing reactive oxygen species-mediated PKCδ/NF-κB pathway

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562737

Puerarin induces the upregulation of glutathione levels and nuclear translocation of Nrf2 through PI3K/Akt/GSK-3β signaling events in PC12 cells exposed to lead

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562737

Antioxidative and anti-inflammatory activities of paeoniflorin and oxypaeoniflora on AGEs-induced mesangial cell damage

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562737

Protective effects of thymoquinone against cholestatic oxidative stress and hepatic damage after biliary obstruction in rats.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562737

Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562737

Lipid and protein oxidation in hepatic homogenates and cell membranes exposed to bile acids.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562737

The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562737

Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562737

Vasodilatory effects of ethanol extract of Radix Paeoniae Rubra and its mechanism of action in the rat aorta

23 September 2018

1 reference

12 December 2020

Change in hepatic antioxidant defense system with liver injury development in rats with a single alpha-naphthylisothiocyanate intoxication

1 reference

12 December 2020

Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems

1 reference

12 December 2020

Hepatoprotective action of Radix Paeoniae Rubra aqueous extract against CCl4-induced hepatic damage.

1 reference

12 December 2020

Induction of Nrf2 and metallothionein as a common mechanism of hepatoprotective medicinal herbs

1 reference

12 December 2020

Paeoniflorin protects against ANIT-induced cholestasis by ameliorating oxidative stress in rats

1 reference

12 December 2020

Drug-induced cholestasis

1 reference

12 December 2020

Identifiers

DOI

10.2147/DDDT.S90030

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

26366057

1 reference