(Q36037764)

11 August 2017

1 reference

title

Interleukin-2, interleukin-15, and their roles in human natural killer cells (English)

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11 August 2017

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2

Michael A Caligiuri

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11 August 2017

Brian Becknell

1

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11 August 2017

publication date

1 January 2005

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11 August 2017

published in

Advances in Immunology

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11 August 2017

volume

86

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11 August 2017

page(s)

209-239

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Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes

11 August 2017

cites work

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IL-15-mediated induction of LFA-1 is a late step required for cytotoxic differentiation of human NK cells from CD34+Lin- bone marrow cells

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Interleukin 2-induced proliferation of murine natural killer cells in vivo

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Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15

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The IL-15R alpha chain signals through association with Syk in human B cells

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Death deflected: IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain

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A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells

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Selective modulation of human natural killer cells in vivo after prolonged infusion of low dose recombinant interleukin 2.

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7 January 2021

Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors

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7 January 2021

Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire

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Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.

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7 January 2021

Recognition of infected cells by natural killer cells

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7 January 2021

A potential role for interleukin-15 in the regulation of human natural killer cell survival

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7 January 2021

CD56bright natural killer cell subsets: characterization of distinct functional responses to interleukin-2 and the c-kit ligand

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7 January 2021

Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor

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7 January 2021

The c-kit ligand suppresses apoptosis of human natural killer cells through the upregulation of bcl-2.

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7 January 2021

Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro

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7 January 2021

In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells

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7 January 2021

NK cell and DC interactions

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7 January 2021

The biology of human natural killer-cell subsets

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7 January 2021

Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset

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7 January 2021

Absence of interleukin 2 production in a severe combined immunodeficiency disease syndrome with T cells

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7 January 2021

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

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7 January 2021

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling

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7 January 2021

IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

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7 January 2021

Multifactorial nature of human immunodeficiency virus disease: implications for therapy

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7 January 2021

Potential mechanisms of human natural killer cell expansion in vivo during low-dose IL-2 therapy

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7 January 2021

CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity

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7 January 2021

Cutting edge: IL-15 costimulates the generalized Shwartzman reaction and innate immune IFN-gamma production in vivo

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7 January 2021

Interleukin 15: biology and relevance to human disease

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7 January 2021

The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic

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7 January 2021

Defective expression of the interleukin-2/interleukin-15 receptor beta subunit leads to a natural killer cell-deficient form of severe combined immunodeficiency

1 reference

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7 January 2021

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor

1 reference

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7 January 2021

Detection of a functional hybrid receptor gammac/GM-CSFRbeta in human hematopoietic CD34+ cells.

1 reference

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7 January 2021

Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor

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7 January 2021

Early IL-2 Production by Mouse Dendritic Cells Is the Result of Microbial-Induced Priming

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7 January 2021

Inducible IL-2 production by dendritic cells revealed by global gene expression analysis.

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7 January 2021

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

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7 January 2021

Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity

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7 January 2021

Expansion of natural killer cells but not T cells in human interleukin 2/interleukin 2 receptor (Tac) transgenic mice

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7 January 2021

Rational interleukin 2 therapy for HIV positive individuals: daily low doses enhance immune function without toxicity

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7 January 2021

Turnover and proliferation of NK cells in steady state and lymphopenic conditions

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7 January 2021

Regulation of Akt-dependent cell survival by Syk and Rac.

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7 January 2021

Autocrine/paracrine IL-15 that is required for type I IFN-mediated dendritic cell expression of MHC class I-related chain A and B is impaired in hepatitis C virus infection

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7 January 2021

Differential Roles for IL-15R α-Chain in NK Cell Development and Ly-49 Induction

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7 January 2021

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

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7 January 2021

Ultra low dose interleukin-2 therapy promotes a type 1 cytokine profile in vivo in patients with AIDS and AIDS-associated malignancies

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7 January 2021

In vivo natural killer cell activities revealed by natural killer cell-deficient mice

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7 January 2021

Interleukin (IL)-15Rα–deficient Natural Killer Cells Survive in Normal but Not IL-15Rα–deficient Mice

1 reference

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7 January 2021

Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice

1 reference

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7 January 2021

Immune responses in interleukin-2-deficient mice

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7 January 2021

Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule

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7 January 2021

Role of Jak kinases and STATs in cytokine signal transduction

1 reference

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7 January 2021

Regulatory pathways involved in the infection-induced production of IFN-gamma by NK cells

1 reference

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7 January 2021

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation

1 reference

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7 January 2021

Expression of a functional c-kit receptor on a subset of natural killer cells

1 reference

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7 January 2021

IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2986006-1

7 January 2021

Enforced expression of Bcl-2 restores the number of NK cells, but does not rescue the impaired development of NKT cells or intraepithelial lymphocytes, in IL-2/IL-15 receptor beta-chain-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2986006-1

7 January 2021

Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway

1 reference

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7 January 2021

Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

1 reference

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7 January 2021

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1 reference

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7 January 2021

Constitutive expression of high affinity interleukin 2 receptors on human CD16-natural killer cells in vivo

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7 January 2021

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans

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7 January 2021

Defective lymphoid development in mice lacking Jak3

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7 January 2021

Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations

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7 January 2021

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice.

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7 January 2021

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

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7 January 2021

Activation of natural killer cells via the p75 interleukin 2 receptor

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7 January 2021

Administration of recombinant interleukin 2 to mice enhances production of hemopoietic and natural killer cells

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7 January 2021

Production and differentiation of NK lineage cells in long-term bone marrow cultures in the absence of exogenous growth factors

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7 January 2021

Interleukin 2 mediates p72 syk activation in peripheral blood lymphocytes

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7 January 2021

IL-15 is an essential mediator of peripheral NK-cell homeostasis

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7 January 2021

A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone

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7 January 2021

Identification of committed NK cell progenitors in adult murine bone marrow

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7 January 2021

Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants

1 reference

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7 January 2021

Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice.

1 reference

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7 January 2021

Transregulation of memory CD8 T-cell proliferation by IL-15Rα+ bone marrow–derived cells

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7 January 2021

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

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7 January 2021

IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity

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7 January 2021

Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor

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https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2986006-1

7 January 2021

IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors

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7 January 2021

Interleukin-2: inception, impact, and implications

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7 January 2021

Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2986006-1

7 January 2021

Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2986006-1

7 January 2021

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

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https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2986006-1

7 January 2021

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2986006-1

7 January 2021

Generation of lytic natural killer 1.1+, Ly-49- cells from multipotential murine bone marrow progenitors in a stroma-free culture: definition of cytokine requirements and developmental intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2986006-1

7 January 2021

Interleukin 2 receptor signaling regulates the perforin gene through signal transducer and activator of transcription (Stat)5 activation of two enhancers

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https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2986006-1

7 January 2021

A role for NF-kappa B activation in perforin expression of NK cells upon IL-2 receptor signaling

1 reference

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7 January 2021

Human Monocytes Constitutively Express Membrane-Bound, Biologically Active, and Interferon-γ–Upregulated Interleukin-15

1 reference

18 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1182/BLOOD.V93.10.3531.410K32_3531_3539

Identifiers

DOI

10.1016/S0065-2776(04)86006-1

1 reference

11 August 2017

1 reference