(Q36042394)

11 August 2017

Comparisons of actin filament disruptors and Rho kinase inhibitors as potential antiglaucoma medications (English)

1 reference

11 August 2017

1 reference

Baohe Tian

1

1 reference

PMCID

3378243

11 August 2017

Paul L Kaufman

series ordinal

2

1 reference

11 August 2017

1 April 2012

1 reference

Expert Review of Ophthalmology

11 August 2017

1 reference

11 August 2017

7

1 reference

11 August 2017

2

1 reference

11 August 2017

177-187

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

11 August 2017

1 reference

Novel ocular antihypertensive compounds in clinical trials

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

The effect of biophysical attributes of the ocular trabecular meshwork associated with glaucoma on the cell response to therapeutic agents

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Advancements in ocular drug delivery

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

The chemistry and biology of cytochalasans

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Adherens junctions remain dynamic

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Role of insulin in regulation of Na+-/K+-dependent ATPase activity and pump function in corneal endothelial cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Adherens junctions connect stress fibres between adjacent endothelial cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Self-complementary AAV virus (scAAV) safe and long-term gene transfer in the trabecular meshwork of living rats and monkeys

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Prolonged transgene expression with lentiviral vectors in the aqueous humor outflow pathway of nonhuman primates

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

The trabecular meshwork outflow pathways: structural and functional aspects.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Rho-kinase-mediated suppression of KDR current in cerebral arteries requires an intact actin cytoskeleton

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Extracellular matrix turnover and outflow resistance

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

The role of the actomyosin system in regulating trabecular fluid outflow

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Applications for ROCK kinase inhibition

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Caldesmon effects on the actin cytoskeleton and cell adhesion in cultured HTM cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Mechanisms of AAV transduction in glaucoma-associated human trabecular meshwork cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

The number of people with glaucoma worldwide in 2010 and 2020

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Effects of topical H-7 on outflow facility, intraocular pressure, and corneal thickness in monkeys

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

RAS and RHO GTPases in G1-phase cell-cycle regulation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Calcium-dependent and calcium-independent contractions in smooth muscles

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Characterization and purification of truncated human Rho-kinase II expressed in Sf-21 cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Effect of H-7 on cultured human trabecular meshwork cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Rho-kinase--mediated contraction of isolated stress fibers

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Effect of latrunculin-A on morphology and actin-associated adhesions of cultured human trabecular meshwork cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

A major role for the rho-associated coiled coil forming protein kinase in G-protein-mediated Ca2+ sensitization through inhibition of myosin phosphatase in rabbit trachea

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Acute and chronic structural effects of pilocarpine on monkey outflow tissues.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Molecular interactions in the submembrane plaque of cell-cell and cell-matrix adhesions.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Studies on the cornea. IX. Physiologic and morphologic effects of cytochalasin B on endothelium of rabbit corneas perfused in vitro

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Cytochalasin B-induced structural changes in the anterior ocular segment of the cynomolgus monkey

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Durable, safe, multi-gene lentiviral vector expression in feline trabecular meshwork

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Mechanical stretch alters the actin cytoskeletal network and signal transduction in human trabecular meshwork cells.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Autoregulation of actin synthesis responds to monomeric actin levels

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Modulation of outflow resistance by the pores of the inner wall endothelium.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Actin structure in the outflow tract of normal and glaucomatous eyes.

11 July 2018

1 reference

Dynamics of actin filaments during tension-dependent formation of actin bundles.

21 January 2018

1 reference

Latrunculins--novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D.

21 January 2018

1 reference

Influence of actin cytoskeletal integrity on matrix metalloproteinase-2 activation in cultured human trabecular meshwork cells.

21 January 2018

1 reference

Inhibitors of actin filament polymerisation attenuate force but not global intracellular calcium in isolated pressurised resistance arteries

21 January 2018

1 reference

Contribution of ROCK in contraction of trabecular meshwork: proposed mechanism for regulating aqueous outflow in monkey and human eyes

21 January 2018

1 reference

Effects of ML-7 and Y-27632 on carbachol- and endothelin-1-induced contraction of bovine trabecular meshwork.

21 January 2018

1 reference

Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility

21 January 2018

1 reference

Effect of low-dose latrunculin B on anterior segment physiologic features in the monkey eye.

21 January 2018

1 reference

Effects of latrunculin-B on outflow facility and trabecular meshwork structure in human eyes.

21 January 2018

1 reference

Pharmacologic disruption of Schlemm's canal cells and outflow facility in anterior segments of human eyes

21 January 2018

1 reference

Monkey organ-cultured anterior segments: technique and response to H-7.

21 January 2018

1 reference

Effects of the Rho kinase inhibitor Y-27632 and the phosphatase inhibitor calyculin A on outflow facility in monkeys

21 January 2018

1 reference

Latrunculin B effects on trabecular meshwork and corneal endothelial morphology in monkeys.

21 January 2018

1 reference

Functional and structural reversibility of H-7 effects on the conventional aqueous outflow pathway in monkeys

21 January 2018

1 reference

Acute effects of H-7 on ciliary epithelium and corneal endothelium in monkey eyes

21 January 2018

1 reference

Enhancement on primate corneal endothelial cell survival in vitro by a ROCK inhibitor.

21 January 2018

1 reference

Caldesmon transgene expression disrupts focal adhesions in HTM cells and increases outflow facility in organ-cultured human and monkey anterior segments.

21 January 2018

1 reference

The effect of C3 transgene expression on actin and cellular adhesions in cultured human trabecular meshwork cells and on outflow facility in organ cultured monkey eyes.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

H-7 disrupts the actin cytoskeleton and increases outflow facility.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378243

Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system

23 September 2018

1 reference

H-7 effects on the structure and fluid conductance of monkey trabecular meshwork

21 January 2018

1 reference

12 December 2020

Cytochalasin B and D dose-outflow facility response relationships in the cynomolgus monkey

1 reference

12 December 2020

Pharmacologic trabeculocanalotomy. Facilitating aqueous outflow by assaulting the meshwork cytoskeleton, junctional complexes, and extracellular matrix

1 reference

12 December 2020

Effect of H-7 and Lat-B on retinal physiology

1 reference

12 December 2020

Effect of diuretics, channel modulators and signal interceptors on contractility of the trabecular meshwork

1 reference

12 December 2020

Latrunculins' effects on intraocular pressure, aqueous humor flow, and corneal endothelium

1 reference

12 December 2020

H-7 increases trabecular facility and facility after ciliary muscle disinsertion in monkeys

1 reference

12 December 2020

Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys

1 reference

12 December 2020

Effect of latrunculin-B on outflow facility in monkeys

1 reference

12 December 2020

Acto-myosin drug effects and aqueous outflow function

1 reference

12 December 2020

Polyester nanocapsules as new topical ocular delivery systems for cyclosporin A

1 reference

12 December 2020

The inhibition of sodium, potassium-stimulated ATPase and corneal swelling: the role played by polyols

1 reference

12 December 2020

Effect of staurosporine on outflow facility in monkeys

1 reference

12 December 2020

Latrunculin-A increases outflow facility in the monkey

1 reference

12 December 2020

Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers

1 reference

12 December 2020

Actin polymerization stimulated by contractile activation regulates force development in canine tracheal smooth muscle

1 reference

12 December 2020

Latrunculin-A causes mydriasis and cycloplegia in the cynomolgus monkey

1 reference

12 December 2020

Identifiers

DOI

10.1586/EOP.12.12

1 reference

11 August 2017

1 reference

11 August 2017

1 reference

PMCID

3378243