(Q35762468)

10 August 2017

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title

RAS and RHO GTPases in G1-phase cell-cycle regulation (English)

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10 August 2017

Mathew L Coleman

1

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Michael F. Olson

object named as

Michael F Olson

series ordinal

3

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author name string

Christopher J Marshall

series ordinal

2

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10 August 2017

publication date

1 May 2004

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Nature Reviews Molecular Cell Biology

10 August 2017

published in

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10 August 2017

volume

5

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10 August 2017

issue

5

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10 August 2017

page(s)

355-366

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Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

10 August 2017

cites work

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Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.

31 March 2020

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Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells

31 March 2020

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Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein

31 March 2020

1 reference

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

31 March 2020

1 reference

Loss of Rb overrides the requirement for ERK activity for cell proliferation

31 March 2020

1 reference

Cellular ras and cyclin D1 are required during different cell cycle periods in cycling NIH 3T3 cells

31 March 2020

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Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1.

31 March 2020

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Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions

31 March 2020

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Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

31 March 2020

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Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal To stimulate DNA synthesis

31 March 2020

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Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells

31 March 2020

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Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation

31 March 2020

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Multiple ras effector pathways contribute to G(1) cell cycle progression

31 March 2020

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

31 March 2020

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Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

31 March 2020

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Specific protection against breast cancers by cyclin D1 ablation

31 March 2020

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Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts

31 March 2020

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Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27

31 March 2020

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The p42/p44 mitogen-activated protein kinase activation triggers p27Kip1 degradation independently of CDK2/cyclin E in NIH 3T3 cells.

31 March 2020

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MAP kinase cascade is required for p27 downregulation and S phase entry in fibroblasts and epithelial cells

31 March 2020

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Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

31 March 2020

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Cyclin E-CDK2 is a regulator of p27Kip1.

31 March 2020

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A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

31 March 2020

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PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)

31 March 2020

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

31 March 2020

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Direct control of the Forkhead transcription factor AFX by protein kinase B

31 March 2020

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Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451

31 March 2020

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Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase

31 March 2020

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New functional activities for the p21 family of CDK inhibitors

31 March 2020

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The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

31 March 2020

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p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export

31 March 2020

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Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes

31 March 2020

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The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

31 March 2020

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Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability

31 March 2020

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Evidence that cyclin D1 mediates both growth and proliferation downstream of TOR in hepatocytes

31 March 2020

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Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

31 March 2020

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Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cells

31 March 2020

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Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

31 March 2020

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p70s6k function is essential for G1 progression

31 March 2020

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Ribosomal S6 kinase signaling and the control of translation

31 March 2020

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Regulation of translation initiation factors by signal transduction

31 March 2020

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TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

31 March 2020

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Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

31 March 2020

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The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

31 March 2020

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Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

31 March 2020

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Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

31 March 2020

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

31 March 2020

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Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

31 March 2020

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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

31 March 2020

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

31 March 2020

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Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2

31 March 2020

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gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle

31 March 2020

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The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

31 March 2020

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The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites

31 March 2020

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4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase

31 March 2020

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Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway

31 March 2020

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ERK and p38 inhibit the expression of 4E-BP1 repressor of translation through induction of Egr-1.

31 March 2020

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Activation of p70/p85 S6 kinase by a pathway independent of p21ras

31 March 2020

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Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase

31 March 2020

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Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation

31 March 2020

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Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

31 March 2020

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Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

31 March 2020

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Tiam1 mutations in human renal-cell carcinomas

31 March 2020

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Identification and characterization of the tuberous sclerosis gene on chromosome 16

31 March 2020

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Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

31 March 2020

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The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

31 March 2020

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Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

31 March 2020

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

31 March 2020

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

31 March 2020

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Rheb promotes cell growth as a component of the insulin/TOR signalling network

31 March 2020

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Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

31 March 2020

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Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals

31 March 2020

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A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb

31 March 2020

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Drosophila Rheb GTPase is required for cell cycle progression and cell growth

31 March 2020

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

31 March 2020

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

31 March 2020

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Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

31 March 2020

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Regulation of cellular growth by the Drosophila target of rapamycin dTOR

31 March 2020

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The tuberin-hamartin complex negatively regulates beta-catenin signaling activity

31 March 2020

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A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation

31 March 2020

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Activation of the Ral and phosphatidylinositol 3' kinase signaling pathways by the ras-related protein TC21.

31 March 2020

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Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.

31 March 2020

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RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival

31 March 2020

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Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells

31 March 2020

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R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways.

31 March 2020

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R-Ras3, a brain-specific Ras-related protein, activates Akt and promotes cell survival in PC12 cells

31 March 2020

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Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation.

31 March 2020

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An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1

31 March 2020

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Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

31 March 2020

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Cooperating oncogenes converge to regulate cyclin/cdk complexes.

31 March 2020

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Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

31 March 2020

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High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.

31 March 2020

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Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

31 March 2020

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Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice

31 March 2020

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RhoA influences the nuclear localization of extracellular signal-regulated kinases to modulate p21Waf/Cip1 expression

31 March 2020

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Cytosolic retention of phosphorylated extracellular signal-regulated kinase and a Rho-associated kinase-mediated signal impair expression of p21(Cip1/Waf1) in phorbol 12-myristate-13- acetate-induced apoptotic cells

31 March 2020

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Transformation mediated by RhoA requires activity of ROCK kinases

31 March 2020

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Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

31 March 2020

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Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases

31 March 2020

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Cadherin engagement regulates Rho family GTPases

31 March 2020

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Cell attachment to the extracellular matrix induces proteasomal degradation of p21(CIP1) via Cdc42/Rac1 signaling

31 March 2020

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3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1)

31 March 2020

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cAMP inhibits linoleic acid-induced growth by antagonizing p27(kip1) depletion, but not interfering with the extracellular signal-regulated kinase or AP-1 activities

31 March 2020

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RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activity

31 March 2020

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p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

31 March 2020

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Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression

31 March 2020

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Rho activity can alter the translation of p27 mRNA and is important for RasV12-induced transformation in a manner dependent on p27 status.

31 March 2020

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Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells

31 March 2020

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Timing of cyclin D1 expression within G1 phase is controlled by Rho.

31 March 2020

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Nuclear translocation of LIM kinase mediates Rho-Rho kinase regulation of cyclin D1 expression

31 March 2020

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Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway

31 March 2020

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Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

31 March 2020

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Rac and Cdc42 are potent stimulators of E2F-dependent transcription capable of promoting retinoblastoma susceptibility gene product hyperphosphorylation

31 March 2020

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Characterization of a Rac1 signaling pathway to cyclin D(1) expression in airway smooth muscle cells

31 March 2020

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Dbl and the Rho GTPases activate NF kappa B by I kappa B kinase (IKK)-dependent and IKK-independent pathways

31 March 2020

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Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth

31 March 2020

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p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex

31 March 2020

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The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.

31 March 2020

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Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation

31 March 2020

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Cdc42 promotes G1 progression through p70 S6 kinase-mediated induction of cyclin E expression

31 March 2020

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Integrin-Specific Activation of Rac Controls Progression through the G1 Phase of the Cell Cycle

31 March 2020

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The human c-Ha-ras2 is a processed pseudogene inactivated by numerous base substitutions

31 March 2020

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Role of ERas in promoting tumour-like properties in mouse embryonic stem cells

31 March 2020

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Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1365

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release_lkvm7cti4naaff5tdyckbjcgxe

10 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/lkvm7cti4naaff5tdyckbjcgxe

mapped directly with Wikidata item

24 November 2022

based on heuristic

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