(Q36042528)

11 August 2017

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title

Telomerase reverse transcriptase as target for anti-tumor T cell responses in humans (English)

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11 August 2017

Maurizio Zanetti

1

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11 August 2017

Xavier Hernandez

series ordinal

2

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11 August 2017

Pierre Langlade-Demoyen

series ordinal

3

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11 August 2017

publication date

15 February 2005

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Seminars in Immunopathology

11 August 2017

published in

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11 August 2017

volume

27

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11 August 2017

issue

1

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11 August 2017

page(s)

87-104

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Peptide binding to the most frequent HLA-A class I alleles measured by quantitative molecular binding assays

11 August 2017

cites work

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12 December 2020

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

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12 December 2020

Characterization of HLA-A3-restricted cytotoxic T lymphocytes reactive against the widely expressed tumor antigen telomerase.

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12 December 2020

High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy.

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12 December 2020

Protocol #0207-545: a phase I/II, escalating dose, open-label evaluation of safety, feasibility, and tolerability of transgenic lymphocyte immunization (TLI) vaccine subjects with histologically proven prostate adenocarcinoma

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12 December 2020

Telomerase activity might persist in the human thymus throughout life

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12 December 2020

Telomere lengthening and telomerase activation during human B cell differentiation

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12 December 2020

Lack of tumor recognition by hTERT peptide 540-548-specific CD8(+) T cells from melanoma patients reveals inefficient antigen processing.

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12 December 2020

Cytotoxic T cell immunity against telomerase reverse transcriptase in humans

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12 December 2020

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

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12 December 2020

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

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12 December 2020

Suppression of T cell proliferation by tumor-induced granulocyte-macrophage progenitor cells producing transforming growth factor-beta and nitric oxide

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12 December 2020

Testicular-associated immune deviation and prevention of adjuvant-induced arthritis by three tolerization methods.

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12 December 2020

Antigenicity and immunogenicity of peptide analogues of a low affinity peptide of the human telomerase reverse transcriptase tumor antigen.

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12 December 2020

Activation of telomerase in a human tumor

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12 December 2020

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

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12 December 2020

Erosion of the telomeric single-strand overhang at replicative senescence

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12 December 2020

Telomerase activity in normal and malignant hematopoietic cells

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12 December 2020

Dominance and crypticity of T cell antigenic determinants

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12 December 2020

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12 December 2020

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

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12 December 2020

Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes.

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12 December 2020

Equivalent induction of telomerase-specific cytotoxic T lymphocytes from tumor-bearing patients and healthy individuals

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12 December 2020

Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy

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12 December 2020

Population biology of antigen presentation by MHC class I molecules

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12 December 2020

Control of syngeneic tumor growth by activation of CD8+ T cells: efficacy is limited by migration away from the site and induction of nonresponsiveness

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12 December 2020

Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses

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12 December 2020

The concept of immunological surveillance

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12 December 2020

Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells

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12 December 2020

Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus

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12 December 2020

Structure and function of telomeres

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12 December 2020

Induction of anti-self-immunity to cure cancer

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12 December 2020

Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo

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12 December 2020

Low avidity recognition of self-antigen by T cells permits escape from central tolerance.

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12 December 2020

Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels

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12 December 2020

Regulated expression of telomerase activity in human T lymphocyte development and activation

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12 December 2020

DNA typing for HLA class I alleles: I. Subsets of HLA-A2 and of -A28

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12 December 2020

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

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12 December 2020

A role for CD95 ligand in preventing graft rejection

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12 December 2020

A general strategy to enhance immunogenicity of low-affinity HLA-A2. 1-associated peptides: implication in the identification of cryptic tumor epitopes

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12 December 2020

The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity

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12 December 2020

Quiescent phenotype of tumor-specific CD8+ T cells following immunization

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12 December 2020

The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes

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12 December 2020

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity

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12 December 2020

Isolation and characterization of human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity of T cells directed toward the widely expressed tumor T-cell epitopes of the telomerase catalyti

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12 December 2020

Creation of human tumour cells with defined genetic elements

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12 December 2020

Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity

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12 December 2020

Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia

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12 December 2020

Unraveling immune privilege

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12 December 2020

Immunization of patients with the hTERT:540-548 peptide induces peptide-reactive T lymphocytes that do not recognize tumors endogenously expressing telomerase

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12 December 2020

Identification of human telomerase reverse transcriptase-derived peptides that induce HLA-A24-restricted antileukemia cytotoxic T lymphocytes

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12 December 2020

Telomerase catalytic subunit homologs from fission yeast and human

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12 December 2020

The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes

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12 December 2020

Genetic polymorphism within HLA-A*02: significant allelic variation revealed in different populations.

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12 December 2020

Design and evaluation of antigen-specific vaccination strategies against cancer.

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12 December 2020

Progress in human tumour immunology and immunotherapy

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12 December 2020

The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoire

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12 December 2020

Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

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12 December 2020

A survey of telomerase activity in human cancer

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12 December 2020

Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia

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12 December 2020

Cytotoxic T cell response against the chimeric ETV6-AML1 protein in childhood acute lymphoblastic leukemia

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12 December 2020

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

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12 December 2020

Essential role of mouse telomerase in highly proliferative organs

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12 December 2020

Clinical implications of telomerase in cancer

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12 December 2020

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

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12 December 2020

Exploring immunological specificity using synthetic peptide combinatorial libraries.

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12 December 2020

Identification of a human telomerase reverse transcriptase peptide of low affinity for HLA A2.1 that induces cytotoxic T lymphocytes and mediates lysis of tumor cells.

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12 December 2020

Telomerase activity, cell proliferation, and cancer

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12 December 2020

Extension of life-span by introduction of telomerase into normal human cells

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12 December 2020

HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice

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12 December 2020

Tumor antigens recognized by T cells

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12 December 2020

Probing degeneracy in T-cell recognition using peptide combinatorial libraries

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12 December 2020

Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism

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12 December 2020

Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes.

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12 December 2020

Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules

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12 December 2020

Immunological Surveillance in Neoplasia

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12 December 2020

In vivo telomere dynamics of human hematopoietic stem cells

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12 December 2020

Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation

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12 December 2020

Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8.

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12 December 2020

Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells

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12 December 2020

T cell tolerance by clonal elimination in the thymus

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12 December 2020

T and Tn, general carcinoma autoantigens

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12 December 2020

CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose

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12 December 2020

Mammalian telomere dynamics: healing, fragmentation shortening and stabilization

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12 December 2020

10.1007/S00281-004-0197-8

Identifiers

DOI

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11 August 2017

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