(Q36042664)

11 August 2017

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title

Relevance of atypical protein kinase C isotypes to the drug discovery process (English)

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11 August 2017

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Marcel Jenny

1

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11 August 2017

Oliver A Wrulich

series ordinal

2

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11 August 2017

Wolfgang Schwaiger

series ordinal

3

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11 August 2017

Florian Ueberall

series ordinal

4

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11 August 2017

1 March 2005

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11 August 2017

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11 August 2017

6

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11 August 2017

491-499

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11 August 2017

3

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Taxonomy and function of C1 protein kinase C homology domains

11 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Regulation of protein kinase C and role in cancer biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Identification of PKCzetaII: an endogenous inhibitor of cell polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Transcriptional activation of c-fos by oncogenic Ha-Ras in mouse mammary epithelial cells requires the combined activities of PKC-lambda, epsilon and zeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Evidence that atypical protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Phosphatidic acid activation of protein kinase C-zeta overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Insulin and PIP3 activate PKC-zeta by mechanisms that are both dependent and independent of phosphorylation of activation loop (T410) and autophosphorylation (T560) sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Protein kinase Ciota activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Nerve growth factor activates kinases that phosphorylate atypical protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Identification of Src as a novel atypical protein kinase C-interacting protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Crystal structure of the tyrosine kinase domain of the human insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Crystal structure of cyclin-dependent kinase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Novel modular domain PB1 recognizes PC motif to mediate functional protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Structure and ligand recognition of the PB1 domain: a novel protein module binding to the PC motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

The PC motif: a novel and evolutionarily conserved sequence involved in interaction between p40phox and p67phox, SH3 domain-containing cytosolic factors of the phagocyte NADPH oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Molecular recognition in dimerization between PB1 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Assembly of epithelial tight junctions is negatively regulated by Par6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Cell polarity: Par6, aPKC and cytoskeletal crosstalk

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Partitioning-defective protein 6 regulates insulin-dependent glycogen synthesis via atypical protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Regulation of c-Fos and Fra-1 by the MEK5-ERK5 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Atypical protein kinase Clambda binds and regulates p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Protein kinase C zeta isoform is critical for mitogenic signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Specific protection against breast cancers by cyclin D1 ablation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Apoptotic versus proliferative activities in human benign prostatic hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Incidence of apoptosis and cell proliferation in prostate cancer: relationship with TGF-beta1 and bcl-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Ras signalling and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Reversion of Ras- and phosphatidylcholine-hydrolyzing phospholipase C-mediated transformation of NIH 3T3 cells by a dominant interfering mutant of protein kinase C lambda is accompanied by the loss of constitutive nuclear mitogen-activated protein k

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Activation of IkappaB kinase beta by protein kinase C isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Role of zeta PKC in B-cell signaling and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Protein kinase C targeting in antineoplastic treatment strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Mapping of atypical protein kinase C within the nerve growth factor signaling cascade: relationship to differentiation and survival of PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Interaction between ATM protein and c-Abl in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Activation of protein kinase C delta by the c-Abl tyrosine kinase in response to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

The nuclear tyrosine kinase c-Abl negatively regulates cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

STAT5-Dependent CyclinD1 and Bcl-xL expression in Bcr-Abl-transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Regulation of cell survival by atypical protein kinase C isozymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

OPR, PC and AID: all in the PB1 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Unique Structural and Functional Properties of the ATP-binding Domain of Atypical Protein Kinase C-ι

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200400186

21 January 2018

Identifiers

DOI

10.1002/CBIC.200400186

1 reference

11 August 2017

1 reference