(Q36062468)

English

Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

author name string

Dariusz Pytel

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Kathleen Seyb

2

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Min Liu

3

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Soumya S Ray

4

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

John Concannon

5

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Mickey Huang

6

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Gregory D Cuny

7

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

J Alan Diehl

8

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Marcie A Glicksman

9

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

publication date

5 March 2014

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Journal of Biomolecular Screening

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

19

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

7

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

1024-1034

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

Synthesis and cytotoxic activity of new β-carboline derivatives.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

The structure of the PERK kinase domain suggests the mechanism for its activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2--discovery of LRRK2 inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

PERK-dependent regulation of IAP translation during ER stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

beta-Carboline alkaloids: biochemical and pharmacological functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

Effects of canthin-6-one alkaloids from Zanthoxylum chiloperone on Trypanosoma cruzi-infected mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

1-Methoxy-canthin-6-one induces c-Jun NH2-terminal kinase-dependent apoptosis and synergizes with tumor necrosis factor-related apoptosis-inducing ligand activity in human neoplastic cells of hematopoietic or endodermal origin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

2 October 2017

ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4570879

27 July 2018

Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: characterization of the kinase and GTPase activities

1 reference

https://api.crossref.org/works/10.1177%2F1087057114525853

21 January 2018

Homogeneous proximity tyrosine kinase assays: scintillation proximity assay versus homogeneous time-resolved fluorescence.

1 reference

https://api.crossref.org/works/10.1177%2F1087057114525853

21 January 2018

Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors

1 reference

https://api.crossref.org/works/10.1177%2F1087057114525853

21 January 2018

Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity

1 reference

https://api.crossref.org/works/10.1177%2F1087057114525853

21 January 2018

The unfolded protein response is activated in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1177%2F1087057114525853

21 January 2018

Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1177%2F1087057114525853

21 January 2018

Alkaloids from Rutaceae: activities of canthin-6-one alkaloids and synthetic analogues on glioblastoma stems cells

1 reference

https://api.crossref.org/works/10.1177%2F1087057114525853

21 January 2018

Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

1 reference

https://pubmed.ncbi.nlm.nih.gov/24598103

12 December 2020

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Axonal and neuronal amyloid precursor protein immunoreactivity in the brains of guinea pigs given tunicamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/24598103

12 December 2020

based on heuristic

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The unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/24598103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1177/1087057114525853

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

ResearchGate publication ID

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