(Q36062689)

11 August 2017

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title

Mammalian carboxylesterases: from drug targets to protein therapeutics (English)

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11 August 2017

1

Matthew R Redinbo

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11 August 2017

Philip M Potter

2

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11 August 2017

publication date

1 March 2005

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11 August 2017

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11 August 2017

volume

10

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11 August 2017

issue

5

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11 August 2017

page(s)

313-325

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Pharmacokinetics and molecular detoxication

11 August 2017

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7 January 2021

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7 January 2021

Molecular aspects of carboxylesterase isoforms in comparison with other esterases

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7 January 2021

Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver

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7 January 2021

cDNA cloning, characterization and stable expression of novel human brain carboxylesterase

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7 January 2021

Regulation of cyp3a gene transcription by the pregnane x receptor

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7 January 2021

Characterization of nonspecific esterase activity in macrophages and intestinal epithelium of the rat

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7 January 2021

Human plasma carboxylesterase and butyrylcholinesterase enzyme activity: correlations with SN-38 pharmacokinetics during a prolonged infusion of irinotecan

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7 January 2021

Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine

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7 January 2021

Human liver cocaine esterases: ethanol-mediated formation of ethylcocaine.

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7 January 2021

Human carboxylesterase 1: from drug metabolism to drug discovery

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7 January 2021

Fatty acid ethyl esters: potentially toxic products of myocardial ethanol metabolism.

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7 January 2021

Purification and characterization of human heart fatty acid ethyl ester synthase/carboxylesterase

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7 January 2021

Myocardial cell damage by fatty acid ethyl esters

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7 January 2021

Mitochondrial dysfunction induced by fatty acid ethyl esters, myocardial metabolites of ethanol

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7 January 2021

Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases.

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7 January 2021

Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase

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7 January 2021

Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials

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7 January 2021

Refined crystal structure of dogfish M4 apo-lactate dehydrogenase

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7 January 2021

Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea

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7 January 2021

CPT-11 (Irinotecan) in the treatment of colorectal cancer

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7 January 2021

Direct translation of a protracted irinotecan schedule from a xenograft model to a phase I trial in children

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7 January 2021

Efficacy of oral irinotecan against neuroblastoma xenografts

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7 January 2021

Phase I and pharmacologic study of irinotecan in combination with cisplatin for advanced lung cancer

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7 January 2021

Characterization of multiple promoters in the human carboxylesterase 2 gene

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7 January 2021

Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity

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7 January 2021

Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy

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7 January 2021

Acyl-coenzyme A:cholesterol O-acyltransferase is not identical to liver microsomal carboxylesterase

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7 January 2021

Cholesteryl ester hydrolase in human monocyte/macrophage: cloning, sequencing, and expression of full-length cDNA

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7 January 2021

Cloning of the human cholesteryl ester hydrolase promoter: identification of functional peroxisomal proliferator-activated receptor responsive elements

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7 January 2021

Mobilization of cytoplasmic CE droplets by overexpression of human macrophage cholesteryl ester hydrolase

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7 January 2021

Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms

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7 January 2021

Comparison of Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris, Spodoptera frugiperda, and COS7 cells for recombinant gene expression. Application to a rabbit liver carboxylesterase

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7 January 2021

The phenomenon of the acute phase response

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7 January 2021

Identification of a C-reactive protein binding site in two hepatic carboxylesterases capable of retaining C-reactive protein within the endoplasmic reticulum

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7 January 2021

The signal for retention of the egasyn-glucuronidase complex within the endoplasmic reticulum

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7 January 2021

Involvement of the esterase active site of egasyn in compartmentalization of β-glucuronidase within the endoplasmic reticulum

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7 January 2021

Structural insights into CPT-11 activation by mammalian carboxylesterases

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7 January 2021

Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition

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7 January 2021

Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme

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7 January 2021

Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics

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7 January 2021

Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin

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7 January 2021

Carboxylesterase: specificity and spontaneous reactivation of an endogenous scavenger for organophosphorus compounds

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7 January 2021

Activation of prodrugs by targeted enzymes

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7 January 2021

Activation of prodrugs by antibody-enzyme conjugates: a new approach to cancer therapy.

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7 January 2021

Identification and activities of human carboxylesterases for the activation of CPT-11, a clinically approved anticancer drug

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7 January 2021

Selective activation of anticancer prodrugs by monoclonal antibody-enzyme conjugates

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7 January 2021

10.1016/S1359-6446(05)03383-0

Identifiers

DOI

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11 August 2017

1 reference