(Q36066308)

12 August 2017

1 reference

title

GABA and glutamate systems as therapeutic targets in depression and mood disorders (English)

1 reference

12 August 2017

Steven F Kendell

1

1 reference

12 August 2017

John H Krystal

series ordinal

2

1 reference

12 August 2017

Gerrard Sanacora

series ordinal

3

1 reference

12 August 2017

language of work or name

English

0 references

publication date

1 February 2005

1 reference

Expert Opinion on Therapeutic Targets

12 August 2017

1 reference

12 August 2017

9

1 reference

12 August 2017

1

1 reference

12 August 2017

153-168

1 reference

Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study

12 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Progress in psychiatry (2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

GABA and mood disorders: a brief review and hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

GABA function in mood disorders: an update and critical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Central GABAergic systems and depressive illness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

GABAergic dysfunction in mood disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

GABA and behavior: the role of receptor subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Regulation of gamma-aminobutyric acid synthesis in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Metabolism and role of glutamate in mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Release of glutamate, aspartate, and gamma-aminobutyric acid from isolated nerve terminals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Biological function of GABAA/benzodiazepine receptor heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

The neuropsychopharmacological potential of neuroactive steroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

GABA-induced synaptic facilitation at type B to A photoreceptor connections in Hermissenda.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Stress and beta-carbolines decrease the density of low affinity GABA binding sites; an effect reversed by diazepam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Foot-shock stress and anxiogenic beta-carbolines increase t-[35S]butylbicyclophosphorothionate binding in the rat cerebral cortex, an effect opposite to anxiolytics and gamma-aminobutyric acid mimetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Foot-shock stress enhances the increase of [35S]TBPS binding in the rat cerebral cortex and the convulsions induced by isoniazid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

On the role of endogenous GABA in the forced swimming test in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Area-dependent changes in GABAergic function after acute and chronic cold stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

GABAA receptors mediate the changes produced by stress on GABA function and locomotor activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Decreased in vivo binding to brain benzodiazepine receptors during social isolation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Variations in maternal care in infancy regulate the development of stress reactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

The gabaergic hypothesis of depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Increased cortical GABA concentrations in depressed patients receiving ECT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Evidence for the segregation of a major gene for human plasma GABA levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Mutation screen of the glutamate decarboxylase-67 gene and haplotype association to unipolar depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Possible association between a haplotype of the GABA-A receptor alpha 1 subunit gene (GABRA1) and mood disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Benzodiazepines in Depressive Disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Tiagabine in treatment refractory bipolar disorder: a clinical case series.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Effects of anticonvulsant drug gabapentin on the enzymes in metabolic pathways of glutamate and GABA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Pregabalin: a new anxiolytic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Acute effects of gabapentin and pregabalin on rat forebrain cellular GABA, glutamate, and glutamine concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Review of the use of topiramate for treatment of bipolar disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Use of topiramate, a new anti-epileptic as a mood stabilizer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Adjunctive topiramate in bipolar II disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Novel neurotransmitters and their neuropsychiatric relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Clinical studies implementing glutamate neurotransmission in mood disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Glutamatergic influences on the basal ganglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

The high affinity uptake system for excitatory amino acids in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Opposing roles of synaptic and extrasynaptic NMDA receptors in neuronal calcium signalling and BDNF gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

NR2B selective NMDA receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Anxiolytic activity of the MGLU2/3 receptor agonist LY354740 on the elevated plus maze is associated with the suppression of stress-induced c-Fos in the hippocampus and increases in c-Fos induction in several other stress-sensitive brain regions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

A role for noradrenergic transmission in the actions of phencyclidine and the antipsychotic and antistress effects of mGlu2/3 receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Serotonergic/glutamatergic interactions: the effects of mGlu 2/3 receptor ligands in rats trained with LSD and PCP as discriminative stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Toluene-induced locomotor activity is blocked by 6-hydroxydopamine lesions of the nucleus accumbens and the mGluR2/3 agonist LY379268.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Metabotropic glutamate receptors: potential drug targets for the treatment of schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

The mGlu receptor ligand (S)-4C3HPG protects neurons after global ischaemia in gerbils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Synthesis and pharmacological characterisation of 2,4-dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

The mGluR5 selective antagonist 6-methyl-2-(phenylethynyl)-pyridine reduces the spinal neuron pain-related activity in mononeuropathic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Selective blockade of type-1 metabotropic glutamate receptors induces neuroprotection by enhancing gabaergic transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Antidepressant-like actions of an AMPA receptor potentiator (LY392098).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

AMPA receptor modulators as cognitive enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress: effects of pretreatment with saline or diazepam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Corticosterone alters N-methyl-D-aspartate receptor subunit mRNA expression before puberty

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Hippocampal atrophy in recurrent major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Glial reduction in the subgenual prefrontal cortex in mood disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

N-methyl-D-aspartate (NMDA)-mediated corticotropin-releasing factor (CRF) release in cultured rat amygdala neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Serum levels of excitatory amino acids, serine, glycine, histidine, threonine, taurine, alanine and arginine in treatment-resistant depression: modulation by treatment with antidepressants and prediction of clinical responsivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Brain amino acid concentrations and Ca2+-dependent release in intractable depression assessed antemortem

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

NMDA glutamatergic receptors, labelled with [3H]MK-801, in brain samples from drug-free depressed suicides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Adaptation of the NMDA receptor in rat cortex following chronic electroconvulsive shock or imipramine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Differential effects of electroconvulsive shock on the glutamate receptor mRNAs for NR2A, NR2B and mGluR5b.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Antidepressant-like effects of NMDA-receptor antagonist injected into the dorsal hippocampus of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Chronic treatment with antidepressants affects glycine/NMDA receptor function: behavioral evidence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Down-regulation of cortical beta-adrenoceptors by chronic treatment with functional NMDA antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

NMDA receptor antagonist treatment induces a long-lasting increase in the number of proliferating cells, PSA-NCAM-immunoreactive granule neurons and radial glia in the adult rat dentate gyrus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Prolonged effect of an anesthetic dose of ketamine on behavioral despair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

D-cycloserine, a positive modulator of the N-methyl-D-aspartate receptor, enhances performance of learning tasks in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

D-cycloserine: a ligand for the N-methyl-D-aspartate coupled glycine receptor has partial agonist characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Actions of D-cycloserine at the N-methyl-D-aspartate-associated glycine receptor site in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Word recognition memory before and after successful treatment of depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Amantadine as augmentation therapy in the management of treatment-resistant depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Antidepressant effects of ketamine in depressed patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Small-dose ketamine improves the postoperative state of depressed patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Organization of N-methyl-D-aspartate glutamate receptor gene expression in the basal ganglia of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Metabotropic glutamate 2/3 receptors as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Presynaptic group I metabotropic glutamate receptors modulate synaptic transmission in the rat superior colliculus via 4‐AP sensitive K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

The selective group mGlu2/3 receptor agonist LY379268 suppresses REM sleep and fast EEG in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

A single residue contributes sensitivity to allosteric modulation of AMPA receptors by LY395153.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Chronic AMPA receptor potentiator (LY451646) treatment increases cell proliferation in adult rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Lamotrigine in the treatment of bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Lamotrigine update and its use in mood disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Novel treatments for bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Clinical predictors of response to lamotrigine and gabapentin monotherapy in refractory affective disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Beneficial effects of the antiglutamatergic agent riluzole in a patient diagnosed with obsessive-compulsive disorder and major depressive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Riluzole anesthesia: use-dependent block of presynaptic glutamate fibers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Modulation of synaptic plasticity by stress and antidepressants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Acute application of the tricyclic antidepressant desipramine presynaptically stimulates the exocytosis of glutamate in the hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Functional antagonists at the NMDA receptor complex exhibit antidepressant actions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Behavioral effects in the elevated plus maze of an NMDA antagonist injected into the dorsal hippocampus: influence of restraint stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

Role of kainate receptors in nociception

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.153

21 January 2018

Identifiers

DOI

10.1517/14728222.9.1.153

1 reference

12 August 2017

1 reference