(Q36072084)

English

Use of antisense oligonucleotides targeting the cytoprotective gene, clusterin, to enhance androgen- and chemo-sensitivity in prostate cancer

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

1 reference

Europe PubMed Central

Use of antisense oligonucleotides targeting the cytoprotective gene, clusterin, to enhance androgen- and chemo-sensitivity in prostate cancer (English)

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

prostate cancer

1 reference

based on heuristic

inferred from title

author name string

Martin Gleave

1

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

Hideaki Miyake

2

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

26 January 2005

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

World Journal of Urology

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

23

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

38-46

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

https://scigraph.springernature.com/pub.10.1007/s00345-004-0474-0

0 references

Epidermal growth factor receptor activation in androgen-independent but not androgen-stimulated growth of human prostatic carcinoma cells

1 reference

https://api.crossref.org/works/10.1007%2FS00345-004-0474-0

21 January 2018

Mitogen-activated protein kinase kinase kinase 1 activates androgen receptor-dependent transcription and apoptosis in prostate cancer

1 reference

https://api.crossref.org/works/10.1007%2FS00345-004-0474-0

21 January 2018

Overexpression of clusterin in human breast carcinoma

1 reference

https://api.crossref.org/works/10.1007%2FS00345-004-0474-0

21 January 2018

Lack of association between enhanced TRPM-2/clusterin expression and increased apoptotic activity in sex-hormone-induced prostatic dysplasia of the Noble rat.

1 reference

https://api.crossref.org/works/10.1007%2FS00345-004-0474-0

21 January 2018

Stress-induced transcription of the clusterin/apoJ gene.

1 reference

https://api.crossref.org/works/10.1007%2FS00345-004-0474-0

21 January 2018

Repression of IR-Inducible Clusterin Expression by the p53 Tumor Suppressor Protein

1 reference

https://api.crossref.org/works/10.1007%2FS00345-004-0474-0

21 January 2018

Active cell death in hormone-dependent tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic organization and expression of the rat TRPM-2 (clusterin) gene, a gene implicated in apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of differentially expressed genes in lymphomas using cDNA arrays: identification of clusterin as a new diagnostic marker for anaplastic large-cell lymphomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of the apoptosis-suppressing oncoprotein bc1-2 in hormone-refractory human prostate cancers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular determinants of resistance to antiandrogen therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin regulates drug-resistance in melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemically modified oligonucleotides exhibit decreased immune stimulation in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overview of phase III trials on combined androgen treatment in patients with metastatic prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of the long and the short forms of Bcl-X in several human and murine tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of insulin-like growth factor binding protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of phosphatidylinositol 3'-kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2'-O-(2-methoxy)ethyl chemistry.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Androgen-repressed messages in the rat ventral prostate

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleotide-based therapies targeting clusterin chemosensitize human lung adenocarcinoma cells both in vitro and in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced radiation sensitivity in prostate cancer by inhibition of the cell survival protein clusterin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of androgen withdrawal on the stem cell composition of the Shionogi carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progression to androgen independence is delayed by adjuvant treatment with antisense Bcl-2 oligodeoxynucleotides after castration in the LNCaP prostate tumor model

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin protects against oxidative stress in vitro through aggregative and nonaggregative properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct sites of production and deposition of the putative cell death marker clusterin in the human thymus

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense Bcl-2 oligodeoxynucleotides inhibit progression to androgen-independence after castration in the Shionogi tumor model

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin: a role in cell survival in the face of apoptosis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct transactivation of the anti-apoptotic gene apolipoprotein J (clusterin) by B-MYB

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hormone therapy failure in human prostate cancer: analysis by complementary DNA and tissue microarrays.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemosensitization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 oligodeoxynucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to cytotoxic chemotherapy-induced apoptosis in human prostate cancer cells is associated with intracellular clusterin expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin as a possible predictor for biochemical recurrence of prostate cancer following radical prostatectomy with intermediate Gleason scores: a preliminary report

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin and the kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin Biogenesis Is Altered during Apoptosis in the Regressing Rat Ventral Prostate

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of androgen-dependent human prostate cancer cells from oxidative stress-induced DNA damage by overexpression of clusterin and its modulation by androgen

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

YB-1 is upregulated during prostate cancer tumor progression and increases P-glycoprotein activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense TRPM-2 oligodeoxynucleotides chemosensitize human androgen-independent PC-3 prostate cancer cells both in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Castration-induced increases in insulin-like growth factor-binding protein 2 promotes proliferation of androgen-independent human prostate LNCaP tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic Applications of Oligonucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical Analysis of Radical Prostatectomy Specimens After 8 Months of Neoadjuvant Hormonal Therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-x(S) anatagonizes the protective effects of Bcl-x(L).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of prostate cell growth by BXL-628, a calcitriol analogue selected for a phase II clinical trial in patients with benign prostate hyperplasia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP-1/c-Jun in the human prostate cancer cell line LNCaP

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

bcl-2 over-expression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein J (clusterin) and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acquisition of chemoresistant phenotype by overexpression of the antiapoptotic gene testosterone-repressed prostate message-2 in prostate cancer xenograft models

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics, tissue distribution, and stability of antisense oligodeoxynucleotide phosphorothioate ISIS 3466 in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin in the male reproductive tract

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Castration-induced apoptosis of androgen-dependent shionogi carcinoma is associated with increased expression of genes encoding insulin-like growth factor-binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxic sensitivity to tumor necrosis factor-alpha in PC3 and LNCaP prostatic cancer cells is regulated by extracellular levels of SGP-2 (clusterin).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Management of hormone refractory prostate cancer: current standards and future prospects

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gp80 (clusterin; TRPM-2) mRNA level is enhanced in human renal clear cell carcinomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic instability coupled to clonal selection as a mechanism for tumor progression in the Dunning R-3327 rat prostatic adenocarcinoma system

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin is a secreted mammalian chaperone

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human gliomas and epileptic foci express high levels of a mRNA related to rat testicular sulfated glycoprotein 2, a purported marker of cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Castration-induced up-regulation of insulin-like growth factor binding protein-5 potentiates insulin-like growth factor-I activity and accelerates progression to androgen independence in prostate cancer models

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of cell death induced by tumor necrosis factor alpha in LNCaP cells by overexpression of sulfated glycoprotein-2 (clusterin).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Testosterone-repressed prostate message-2 is an antiapoptotic gene involved in progression to androgen independence in prostate cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of the cytoprotective protein clusterin decreases radiosensitivity in the human LNCaP prostate tumour model

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin Has Chaperone-like Activity Similar to That of Small Heat Shock Proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic chemsensitization and inhibition of tumor growth and metastasis by the antisense oligodeoxynucleotide targeting clusterin gene in a human bladder cancer model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SGP-2 expression as a genetic marker of progressive cellular pathology in experimental hydronephrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15770517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00345-004-0474-0

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

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