(Q36083972)

12 August 2017

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title

Biogenesis of CFTR and other polytopic membrane proteins: new roles for the ribosome-translocon complex (English)

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12 August 2017

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Sadlish H

1

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PubMed ID

15798900

12 August 2017

Skach WR

series ordinal

2

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12 August 2017

1 December 2004

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12 August 2017

12

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Journal of Membrane Biology

inferred from page(s)

published in

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12 August 2017

202

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12 August 2017

115-126

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12 August 2017

3

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https://scigraph.springernature.com/pub.10.1007/s00232-004-0715-6

12 August 2017

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cites work

Coupled translocation events generate topological heterogeneity at the endoplasmic reticulum membrane

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Crossref

https://api.crossref.org/works/10.1007%2FS00232-004-0715-6

Dissection of de novo membrane insertion activities of internal transmembrane segments of ATP-binding-cassette transporters: toward understanding topological rules for membrane assembly of polytopic membrane proteins

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007%2FS00232-004-0715-6

Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation

21 January 2018

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12 December 2020

Membrane insertion and assembly of ductin: a polytopic channel with dual orientations

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12 December 2020

Architecture of the protein-conducting channel associated with the translating 80S ribosome.

1 reference

12 December 2020

Sec61p contributes to signal sequence orientation according to the positive-inside rule

1 reference

12 December 2020

The cotranslational integration of membrane proteins into the phospholipid bilayer is a multistep process

1 reference

12 December 2020

A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane

1 reference

12 December 2020

Functions of signal and signal-anchor sequences are determined by the balance between the hydrophobic segment and the N-terminal charge

1 reference

12 December 2020

Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation

1 reference

12 December 2020

Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the endoplasmic reticulum membrane

1 reference

12 December 2020

TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation into the endoplasmic reticulum.

1 reference

12 December 2020

Transmembrane orientation and topogenesis of the third and fourth membrane-spanning regions of human P-glycoprotein (MDR1).

1 reference

12 December 2020

Three-dimensional structure of the bacterial protein-translocation complex SecYEG

1 reference

12 December 2020

Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

1 reference

12 December 2020

Regulation of protein topology by trans-acting factors at the endoplasmic reticulum

1 reference

12 December 2020

A nascent membrane protein is located adjacent to ER membrane proteins throughout its integration and translation

1 reference

12 December 2020

Empty site forms of the SRP54 and SR alpha GTPases mediate targeting of ribosome-nascent chain complexes to the endoplasmic reticulum

1 reference

12 December 2020

The distribution of positively charged residues in bacterial inner membrane proteins correlates with the trans-membrane topology

1 reference

12 December 2020

Structure of the mammalian ribosome-channel complex at 17A resolution

1 reference

12 December 2020

The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain

1 reference

12 December 2020

Multiple topogenic sequences in bovine opsin

1 reference

12 December 2020

The signal sequence moves through a ribosomal tunnel into a noncytoplasmic aqueous environment at the ER membrane early in translocation

1 reference

12 December 2020

Mapping the ends of transmembrane segments in a polytopic membrane protein. Scanning N-glycosylation mutagenesis of extracytosolic loops in the anion exchanger, band 3

1 reference

12 December 2020

Signal and membrane anchor functions overlap in the type II membrane protein I gamma CAT.

1 reference

12 December 2020

Multidrug resistance protein (Mdr)-alkaline phosphatase hybrids in Escherichia coli suggest a major revision in the topology of the C-terminal half of Mdr.

1 reference

12 December 2020

Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum

1 reference

12 December 2020

Discrete cross-linking products identified during membrane protein biosynthesis

1 reference

12 December 2020

Control of glycosylation of MHC class II-associated invariant chain by translocon-associated RAMP4.

1 reference

12 December 2020

Both lumenal and cytosolic gating of the aqueous ER translocon pore are regulated from inside the ribosome during membrane protein integration

1 reference

12 December 2020

Molecular mechanism of membrane protein integration into the endoplasmic reticulum

1 reference

12 December 2020

Assessment of topogenic functions of anticipated transmembrane segments of human band 3

1 reference

12 December 2020

Transmembrane biogenesis of Kv1.3.

1 reference

12 December 2020

Biogenesis of Polytopic Membrane Proteins: Membrane Segments Assemble within Translocation Channels prior to Membrane Integration

1 reference

12 December 2020

A two-step recognition of signal sequences determines the translocation efficiency of proteins.

1 reference

12 December 2020

Only the first and the last hydrophobic segments in the COOH-terminal third of Na,K-ATPase alpha subunit initiate and halt, respectively, membrane translocation of the newly synthesized polypeptide. Implications for the membrane topology

1 reference

12 December 2020

Construction of defined polytopic integral transmembrane proteins. The role of signal and stop transfer sequence permutations

1 reference

12 December 2020

Molecular mechanism of P-glycoprotein assembly into cellular membranes

1 reference

12 December 2020

Signal sequence recognition in posttranslational protein transport across the yeast ER membrane.

1 reference

12 December 2020

Intracellular protein topogenesis

1 reference

12 December 2020

Topogenesis of cystic fibrosis transmembrane conductance regulator (CFTR): regulation by the amino terminal transmembrane sequences

1 reference

12 December 2020

Structural cues involved in endoplasmic reticulum degradation of G85E and G91R mutant cystic fibrosis transmembrane conductance regulator

1 reference

12 December 2020

Membrane protein biogenesis: regulated complexity at the endoplasmic reticulum

1 reference

12 December 2020

Co- and posttranslational translocation mechanisms direct cystic fibrosis transmembrane conductance regulator N terminus transmembrane assembly

1 reference

12 December 2020

A protein of the endoplasmic reticulum involved early in polypeptide translocation

1 reference

12 December 2020

Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane

1 reference

12 December 2020

Amino-terminal assembly of human P-glycoprotein at the endoplasmic reticulum is directed by cooperative actions of two internal sequences

1 reference

12 December 2020

A transmembrane form of the prion protein in neurodegenerative disease

1 reference

12 December 2020

Determination of the distance between the oligosaccharyltransferase active site and the endoplasmic reticulum membrane

1 reference

12 December 2020

Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence

1 reference

12 December 2020

X-ray structure of a protein-conducting channel

1 reference

12 December 2020

Functional expression of mouse mdr1 in Escherichia coli

1 reference

12 December 2020

The organization of engaged and quiescent translocons in the endoplasmic reticulum of mammalian cells

1 reference

12 December 2020

The signal recognition particle

1 reference

12 December 2020

Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins.

1 reference

12 December 2020

Structural requirements for membrane assembly of proteins spanning the membrane several times

1 reference

12 December 2020

The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer.

1 reference

12 December 2020

A novel CFTR disease-associated mutation causes addition of an extra N-linked oligosaccharide

1 reference

12 December 2020

Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein

1 reference

12 December 2020

A new role for BiP: closing the aqueous translocon pore during protein integration into the ER membrane

1 reference

12 December 2020

Transmembrane orientation of signal-anchor proteins is affected by the folding state but not the size of the N-terminal domain.

1 reference

12 December 2020

An unstable transmembrane segment in the cystic fibrosis transmembrane conductance regulator

1 reference

12 December 2020

Determining the structure and mechanism of the human multidrug resistance P-glycoprotein using cysteine-scanning mutagenesis and thiol-modification techniques

1 reference

12 December 2020

The membrane topology of the carboxyl-terminal third of the Neurospora plasma membrane H(+)-ATPase

1 reference

12 December 2020

Membrane integration of the second transmembrane segment of band 3 requires a closely apposed preceding signal-anchor sequence

1 reference

12 December 2020

Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane

1 reference

12 December 2020

Structural insight into the protein translocation channel

1 reference

12 December 2020

The translocon: a dynamic gateway at the ER membrane

1 reference

12 December 2020

Uncoupling translocation from translation: implications for transport of proteins across membranes

1 reference

12 December 2020

The amino terminus of opsin translocates "posttranslationally" as efficiently as cotranslationally

1 reference

12 December 2020

Structure and biosynthesis of the signal-sequence receptor.

1 reference

12 December 2020

Translocons, thermodynamics, and the folding of membrane proteins

1 reference

12 December 2020

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

12 December 2020

Heads or tails--what determines the orientation of proteins in the membrane.

1 reference

12 December 2020

Helical membrane protein folding, stability, and evolution

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12 December 2020

Cooperation of transmembrane segments during the integration of a double-spanning protein into the ER membrane

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12 December 2020

Cooperativity and flexibility of cystic fibrosis transmembrane conductance regulator transmembrane segments participate in membrane localization of a charged residue.

1 reference

12 December 2020

BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation

1 reference

12 December 2020

Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex

1 reference

12 December 2020

Protein translocons: multifunctional mediators of protein translocation across membranes

1 reference

12 December 2020

Topological "frustration" in multispanning E. coli inner membrane proteins.

1 reference

12 December 2020

Cotranslational protein integration into the ER membrane is mediated by the binding of nascent chains to translocon proteins.

1 reference

12 December 2020

Role of Sec61alpha in the regulated transfer of the ribosome-nascent chain complex from the signal recognition particle to the translocation channel

1 reference

12 December 2020

Different transmembrane domains associate with distinct endoplasmic reticulum components during membrane integration of a polytopic protein

1 reference

12 December 2020

Evidence for an alternate model of human P-glycoprotein structure and biogenesis

1 reference

12 December 2020

Identification of sequence determinants that direct different intracellular folding pathways for aquaporin-1 and aquaporin-4.

1 reference

12 December 2020

Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore.

1 reference

12 December 2020

The aqueous pore through the translocon has a diameter of 40-60 A during cotranslational protein translocation at the ER membrane

1 reference

12 December 2020

Topogenesis of membrane proteins: determinants and dynamics.

1 reference

12 December 2020

The Structure of Ribosome-Channel Complexes Engaged in Protein Translocation

1 reference

12 December 2020

10.1007/S00232-004-0715-6

Identifiers

DOI

1 reference

12 August 2017

1 reference

PubMed ID

15798900