(Q36094332)

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The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging

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scholarly article

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Europe PubMed Central

PMC publication ID

12 August 2017

The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging (English)

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

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traumatic brain injury

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2

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Amy K Wagner

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Europe PubMed Central

PMC publication ID

12 August 2017

author name string

Sriram Venneti

1

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Europe PubMed Central

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12 August 2017

Guoji Wang

3

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Europe PubMed Central

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12 August 2017

Susan L Slagel

4

1 reference

Europe PubMed Central

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12 August 2017

Xiangbai Chen

5

1 reference

Europe PubMed Central

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12 August 2017

Brian J Lopresti

6

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Europe PubMed Central

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12 August 2017

Chester A Mathis

7

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Europe PubMed Central

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12 August 2017

Clayton A Wiley

8

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Europe PubMed Central

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12 August 2017

language of work or name

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publication date

19 June 2007

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Europe PubMed Central

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12 August 2017

Experimental Neurology

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Europe PubMed Central

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12 August 2017

207

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Europe PubMed Central

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12 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

118-127

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 October 2017

ATP mediates rapid microglial response to local brain injury in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 October 2017

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 October 2017

PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 October 2017

In vivo imaging of neuroinflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 October 2017

Reciprocal interactions between microglia and neurons: from survival to neuropathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 October 2017

Visualising microglial activation in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 October 2017

Peripheral benzodiazepine receptors and mitochondrial function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 October 2017

Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 October 2017

Microglial response to brain injury: a brief synopsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 October 2017

The role of microglia and macrophages in the pathophysiology of the CNS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 October 2017

Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 October 2017

The role of microglia in brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 October 2017

Microglia: a sensor for pathological events in the CNS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 October 2017

A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 October 2017

In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 July 2018

Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 July 2018

PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 July 2018

Synthesis of the enantiomers of [N-methyl-11C]PK 11195 and comparison of their behaviours as radioligands for PK binding sites in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 July 2018

Macrophage and astrocyte populations in relation to [3H]PK 11195 binding in rat cerebral cortex following a local ischaemic lesion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 July 2018

A controlled cortical impact model of traumatic brain injury in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 July 2018

Brain kinetics and specific binding of [11C]PK 11195 to omega 3 sites in baboons: positron emission tomography study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 July 2018

Monitoring by PET of macrophage accumulation in brain after ischaemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

2 July 2018

Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Up-regulation of PK11195 binding in areas of axonal degeneration coincides with early microglial activation in mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Microglial activation correlates with severity in Huntington disease: a clinical and PET study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Quantitative analysis for estimating binding potential of the peripheral benzodiazepine receptor with [(11)C]DAA1106.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Neuroscience. Brain under surveillance: the microglia patrol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Microglial activation and dopamine terminal loss in early Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Activation of microglial cells and complement following traumatic injury in rat entorhinal-hippocampal slice cultures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: an imaging tool for glial cells in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

[(11)C]DAA1106: radiosynthesis and in vivo binding to peripheral benzodiazepine receptors in mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

PET visualization of microglia in multiple sclerosis patients using [11C]PK11195

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Elevated peripheral benzodiazepine receptor expression in simian immunodeficiency virus encephalitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Intervention with environmental enrichment after experimental brain trauma enhances cognitive recovery in male but not female rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

CD14 expression by activated parenchymal microglia/macrophages and infiltrating monocytes following human traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Attenuation of working memory and spatial acquisition deficits after a delayed and chronic bromocriptine treatment regimen in rats subjected to traumatic brain injury by controlled cortical impact

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Regional vulnerability after traumatic brain injury: gender differences in mice that overexpress human copper, zinc superoxide dismutase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Co-culture with astrocytes or microglia protects metabolically impaired neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

In-vivo measurement of activated microglia in dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Time course of glial proliferation and glial apoptosis following excitotoxic CNS injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Chronic methylphenidate treatment enhances water maze performance following traumatic brain injury in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Binding characteristics of [3H]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

PET of peripheral benzodiazepine binding sites in the microgliosis of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Reactive cell proliferation and microglia following injury to the rat brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2042945

23 September 2018

Traumatic Brain Injury in the United States: A Public Health Perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/17658516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Traumatic brain injury leads to increased expression of peripheral-type benzodiazepine receptors, neuronal death, and activation of astrocytes and microglia in rat thalamus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17658516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17658516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamics of microglial activation after human traumatic brain injury are revealed by delayed expression of macrophage-related proteins MRP8 and MRP14

1 reference

https://pubmed.ncbi.nlm.nih.gov/17658516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo imaging of activated microglia using [11C]PK11195 and positron emission tomography in patients after ischemic stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/17658516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17658516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/17658516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17658516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17658516

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.EXPNEUROL.2007.06.003

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

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