(Q36110574)

12 August 2017

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title

Genetics of Crohn disease, an archetypal inflammatory barrier disease (English)

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12 August 2017

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2

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12 August 2017

4

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12 August 2017

5

Michael Krawczak

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12 August 2017

1

Stefan Schreiber

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12 August 2017

Mario Albrecht

3

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12 August 2017

1 May 2005

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12 August 2017

Nature Reviews Genetics

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12 August 2017

6

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12 August 2017

5

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12 August 2017

376-388

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https://scigraph.springernature.com/pub.10.1038/nrg1607

12 August 2017

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cites work

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

1 reference

The effect of infections on susceptibility to autoimmune and allergic diseases

21 January 2018

1 reference

Inflammatory bowel disease and domestic hygiene in infancy

21 January 2018

1 reference

Association of inflammatory bowel disease with indicators for childhood antigen and infection exposure

21 January 2018

1 reference

Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking

21 January 2018

1 reference

Familial occurrence of inflammatory bowel disease

21 January 2018

1 reference

Genetics versus environment in inflammatory bowel disease: results of a British twin study

21 January 2018

1 reference

Investigation of inheritance of chronic inflammatory bowel diseases by complex segregation analysis

21 January 2018

1 reference

Contribution of the IL-2 and IL-10 genes to inflammatory bowel disease (IBD) susceptibility

21 January 2018

1 reference

Genetic analysis of susceptibility to dextran sulfate sodium-induced colitis in mice.

21 January 2018

1 reference

A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice

21 January 2018

1 reference

Identification of the cystic fibrosis gene: genetic analysis

21 January 2018

1 reference

Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease

21 January 2018

1 reference

Finding genes that underlie complex traits

21 January 2018

1 reference

Obstacles and opportunities in meta-analysis of genetic association studies.

21 January 2018

1 reference

The allelic architecture of human disease genes: common disease-common variant... or not?

21 January 2018

1 reference

Sarcoidosis is associated with a truncating splice site mutation in BTNL2.

21 January 2018

1 reference

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

21 January 2018

1 reference

Diagnostic misclassification reduces the ability to detect linkage in inflammatory bowel disease genetic studies

21 January 2018

1 reference

Biased tests of association: comparisons of allele frequencies when departing from Hardy-Weinberg proportions

21 January 2018

1 reference

Tests and estimates of allelic association in complex inheritance

21 January 2018

1 reference

Evidence for extensive transmission distortion in the human genome

21 January 2018

1 reference

Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan

21 January 2018

1 reference

Genomic control for association studies

21 January 2018

1 reference

Use of unlinked genetic markers to detect population stratification in association studies.

21 January 2018

1 reference

Mapping of a susceptibility locus for Crohn's disease on chromosome 16

21 January 2018

1 reference

Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1.

21 January 2018

1 reference

A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort

21 January 2018

1 reference

Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci

21 January 2018

1 reference

Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16.

21 January 2018

1 reference

American families with Crohn's disease have strong evidence for linkage to chromosome 16 but not chromosome 12

21 January 2018

1 reference

International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16.

21 January 2018

1 reference

Evidence for a NOD2-independent susceptibility locus for inflammatory bowel disease on chromosome 16p.

21 January 2018

1 reference

Linkage of inflammatory bowel disease to human chromosome 6p

21 January 2018

1 reference

Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors

21 January 2018

1 reference

Mapping of a disease susceptibility locus in chromosome 6p in Japanese patients with ulcerative colitis

21 January 2018

1 reference

Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs

21 January 2018

1 reference

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

21 January 2018

1 reference

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

1 reference

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

1 reference

Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

21 January 2018

1 reference

Genetic variation in DLG5 is associated with inflammatory bowel disease

21 January 2018

1 reference

The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease

21 January 2018

1 reference

Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact

21 January 2018

1 reference

IBD5 is a general risk factor for inflammatory bowel disease: replication of association with Crohn disease and identification of a novel association with ulcerative colitis

21 January 2018

1 reference

Functional variants of OCTN cation transporter genes are associated with Crohn disease

21 January 2018

1 reference

Lack of common NOD2 variants in Japanese patients with Crohn's disease

21 January 2018

1 reference

Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations.

21 January 2018

1 reference

Searching for genetic determinants in the new millennium

21 January 2018

1 reference

A genome-wide search identifies potential new susceptibility loci for Crohn's disease

21 January 2018

1 reference

Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease.

21 January 2018

1 reference

Further evidence of IBD5/CARD15 (NOD2) epistasis in the susceptibility to ulcerative colitis

21 January 2018

1 reference

Structural localization of disease-associated sequence variations in the NACHT and LRR domains of PYPAF1 and NOD2.

21 January 2018

1 reference

Genetic association studies: genes in search of diseases.

21 January 2018

1 reference

New approaches to gene hunting in IBD.

21 January 2018

1 reference

Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains

21 January 2018

1 reference

CATERPILLER: a novel gene family important in immunity, cell death, and diseases

21 January 2018

1 reference

Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk

21 January 2018

1 reference

Different intestinal permeability patterns in relatives and spouses of patients with Crohn's disease: an inherited defect in mucosal defence?

21 January 2018

1 reference

Subclinical intestinal inflammation: an inherited abnormality in Crohn’s disease relatives?

21 January 2018

1 reference

Intestinal epithelial toll-like receptors: to protect. And serve?

21 January 2018

1 reference

Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors

21 January 2018

1 reference

Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide

21 January 2018

1 reference

Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells

21 January 2018

1 reference

CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

21 January 2018

1 reference

TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells.

21 January 2018

1 reference

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

21 January 2018

1 reference

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

21 January 2018

1 reference

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

21 January 2018

1 reference

NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression

21 January 2018

1 reference

NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease

21 January 2018

1 reference

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

21 January 2018

1 reference

Interrogating a high-density SNP map for signatures of natural selection

21 January 2018

1 reference

Cell signalling and the control of pre-mRNA splicing.

21 January 2018

1 reference

Alternatively spliced N resistance gene transcripts: their possible role in tobacco mosaic virus resistance

21 January 2018

1 reference

Structure-function analysis of the tobacco mosaic virus resistance gene N

21 January 2018

1 reference

Assessing the impact of alternative splicing on domain interactions in the human proteome

21 January 2018

1 reference

Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity

21 January 2018

1 reference

Commensal host-bacterial relationships in the gut

21 January 2018

1 reference

Interactions between commensal intestinal bacteria and the immune system

21 January 2018

1 reference

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

21 January 2018

1 reference

Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease

21 January 2018

1 reference

Biodiversity and ecosystem productivity in a fluctuating environment: the insurance hypothesis

21 January 2018

1 reference

The diversity-stability debate

21 January 2018

1 reference

Culture of Mycobacterium avium subspecies paratuberculosis from the blood of patients with Crohn's disease.

21 January 2018

1 reference

Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics

21 January 2018

1 reference

Review article: antibiotics and probiotics in inflammatory bowel disease

21 January 2018

1 reference

Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial

21 January 2018

1 reference

21 January 2018

1 reference

HLA-DRB1*1101: A Significant Risk Factor for Sarcoidosis in Blacks and Whites

21 January 2018

1 reference

STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer

21 January 2018

1 reference

Structural, expression, and evolutionary analysis of mouse CIAS1

21 January 2018

1 reference

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

21 January 2018

1 reference

Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties

21 January 2018

1 reference

Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

21 January 2018

1 reference

Patterns of linkage disequilibrium in the MHC region on human chromosome 6p

21 January 2018

1 reference

The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants

21 January 2018

1 reference

Fine mapping of theIBD1 locus did not identify Crohn disease-associatedNOD2 variants: Implications for complex disease genetics

21 January 2018

1 reference

Epidemiology of IBD during the twentieth century: an integrated view

21 January 2018

1 reference

Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee

31 March 2020

1 reference

The genetics of Crohn disease: complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives

31 March 2020

1 reference

Familial aggregation of inflammatory bowel disease in northern Italy: a multicenter study. The Gruppo di Studio per le Malattie Infiammatorie Intestinali (IBD Study Group)

31 March 2020

1 reference

Genetic epidemiology and haplotypes

31 March 2020

1 reference

Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12

31 March 2020

1 reference

Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease

31 March 2020

1 reference

NOD2 3020insC frameshift mutation is not associated with inflammatory bowel disease in Chinese patients of Han nationality.

31 March 2020

1 reference

The International HapMap Project

31 March 2020

1 reference

Intestinal permeability and the prediction of relapse in Crohn's disease

31 March 2020

1 reference

Intestinal epithelial cells and innate immunity in the intestine: is CARD15/Nod2 another player?

31 March 2020

1 reference

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

31 March 2020

1 reference

Results from a genome-wide search for predisposing genes in sarcoidosis

31 March 2020

1 reference

Human leukocyte antigen-DRB1 position 11 residues are a common protective marker for sarcoidosis

31 March 2020

1 reference

Disease-associated variants in PYPAF1 and NOD2 result in similar alterations of conserved sequence

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRG1607

1 reference

12 August 2017

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PubMed ID

15861209