(Q36110578)

12 August 2017

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title

Many little things: one geneticist's view of complex diseases (English)

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12 August 2017

Oliver Smithies

1

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12 August 2017

1 May 2005

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12 August 2017

Nature Reviews Genetics

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12 August 2017

6

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12 August 2017

5

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12 August 2017

419-425

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https://scigraph.springernature.com/pub.10.1038/nrg1605

12 August 2017

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cites work

Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination

1 reference

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

21 January 2018

1 reference

Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells

21 January 2018

1 reference

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

21 January 2018

1 reference

The knockout mouse project

21 January 2018

1 reference

An animal model for cystic fibrosis made by gene targeting

21 January 2018

1 reference

Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E

21 January 2018

1 reference

Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats

21 January 2018

1 reference

Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat

21 January 2018

1 reference

Genetic linkage of the ACE gene to plasma angiotensin-converting enzyme activity but not to blood pressure. A quantitative trait locus confers identical complex phenotypes in human and rat hypertension

21 January 2018

1 reference

Molecular basis of human hypertension: role of angiotensinogen

21 January 2018

1 reference

Double-strand gap repair in a mammalian gene targeting reaction

21 January 2018

1 reference

Genetic control of blood pressure and the angiotensinogen locus

21 January 2018

1 reference

A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro

21 January 2018

1 reference

Importance of quantitative genetic variations in the etiology of hypertension

21 January 2018

1 reference

Why the kidney glomerulus does not clog: a gel permeation/diffusion hypothesis of renal function

21 January 2018

1 reference

The spaces in a uniform random suspension of fibres

21 January 2018

1 reference

Alexander George Ogston. 30 January 1911-29 June 1996: Elected F.R.S. 1955

21 January 2018

1 reference

Human genetics, animal models and computer simulations for studying hypertension

21 January 2018

1 reference

A strategy for increasing an in vivo flux by genetic manipulations. The tryptophan system of yeast

21 January 2018

1 reference

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels

21 January 2018

1 reference

Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse

21 January 2018

1 reference

Targeted disruption of a B2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons.

21 January 2018

1 reference

Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor

21 January 2018

1 reference

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

21 January 2018

1 reference

Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis

21 January 2018

1 reference

A noninvasive computerized tail-cuff system for measuring blood pressure in mice

31 March 2020

1 reference

A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRG1605

1 reference

12 August 2017

1 reference

PubMed ID

15861211