(Q36111546)

12 August 2017

3 references

22 April 2019

25 April 2019

6 July 2020

Molecular and cellular alterations in Down syndrome: toward the identification of targets for therapeutics (English)

1 reference

12 August 2017

3 references

22 April 2019

25 April 2019

6 July 2020

Nicole Créau

1

1 reference

PMC publication ID

3403492

12 August 2017

language of work or name

1 reference

12 July 2012

4 references

12 August 2017

22 April 2019

25 April 2019

6 July 2020

4 references

12 August 2017

22 April 2019

25 April 2019

6 July 2020

2012

1 reference

12 August 2017

171639

1 reference

Creative Commons Attribution 3.0 Unported

12 August 2017

3 references

22 April 2019

25 April 2019

on focus list of Wikimedia project

6 July 2020

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

Brain phenotype of transgenic mice overexpressing cystathionine β-synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

miRNA-155 upregulation and complement factor H deficits in Down's syndrome.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Functions of noncoding RNAs in neural development and neurological diseases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Neurobiological elements of cognitive dysfunction in down syndrome: exploring the role of APP.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Altered regulation of tau phosphorylation in a mouse model of down syndrome aging

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

S100B and APP promote a gliocentric shift and impaired neurogenesis in Down syndrome neural progenitors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Do RCAN1 proteins link chronic stress with neurodegeneration?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Purkinje cell protein 4 positively regulates neurite outgrowth and neurotransmitter release

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Language and verbal short-term memory skills in children with Down syndrome: a meta-analytic review

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Memory profiles of Down, Williams, and fragile X syndromes: implications for reading development

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Development and validation of the Arizona Cognitive Test Battery for Down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Intersecting pathways in cell biology

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

The role of DYRK1A in neurodegenerative diseases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Trisomy-21 gene dosage over-expression of miRNAs results in the haploinsufficiency of specific target proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

The hAPP-YAC transgenic model has elevated UPS activity in the frontal cortex similar to Alzheimer's disease and Down's syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Cognitive deficits and associated neurological complications in individuals with Down's syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Normal protein composition of synapses in Ts65Dn mice: a mouse model of Down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down's syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Prevention of developmental delays in a Down syndrome mouse model

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Altered expression of KIF17, a kinesin motor protein associated with NR2B trafficking, may mediate learning deficits in a Down syndrome mouse model

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Natural gene-expression variation in Down syndrome modulates the outcome of gene-dosage imbalance

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Neonatal mice of the Down syndrome model, Ts65Dn, exhibit upregulated VIP measures and reduced responsiveness of cortical astrocytes to VIP stimulation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Study of somatic chromosomes from 9 mongoloid children

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

The neuropsychology of Down syndrome: evidence for hippocampal dysfunction

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Functional screening and complex traits: human 21q22.2 sequences affecting learning in mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Development of the superior temporal neocortex is anomalous in trisomy 21.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

DYRK1A: a master regulatory protein controlling brain growth.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

An increase in basal BDNF provokes hyperactivation of the Akt-mammalian target of rapamycin pathway and deregulation of local dendritic translation in a mouse model of Down's syndrome.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Total numbers of neurons and glial cells in cortex and basal ganglia of aged brains with Down syndrome--a stereological study.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Overexpression of Dyrk1A causes the defects in synaptic vesicle endocytosis

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Infantile spasms and Down syndrome: a new animal model

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Hippocampal hypocellularity in the Ts65Dn mouse originates early in development

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Abnormal neuronal development in the visual cortex of the human fetus and infant with down's syndrome. A quantitative and qualitative Golgi study.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Dendritic atrophy in children with Down's syndrome

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis

2 July 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Working memory in Down syndrome: is there a dual task deficit?

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Neuroanatomy of Down's syndrome: a high-resolution MRI study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Relationship between brain and cognitive processes in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Cognitive control of movement in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Gene expression profiling in the adult Down syndrome brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

The phenotype of persons having mosaicism for trisomy 21/Down syndrome reflects the percentage of trisomic cells present in different tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Global disruption of the cerebellar transcriptome in a Down syndrome mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Vasoactive intestinal peptide in the brain of a mouse model for Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Alteration of NO-producing system in the basal forebrain and hypothalamus of Ts65Dn mice: an immunohistochemical and histochemical study of a murine model for Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Minocycline prevents cholinergic loss in a mouse model of Down's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Axonal abnormalities in cerebellar Purkinje cells of the Ts65Dn mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Beta-amyloid overload does not directly correlate with SAPK/JNK activation and tau protein phosphorylation in the cerebellar cortex of Ts65Dn mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Developmental defects in trisomy 21 and mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

A medical enigma: persons with Down syndrome do not develop medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Impaired plasticity at specific subset of striatal synapses in the Ts65Dn mouse model of Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Gain-of-function of Olig transcription factors enhances oligodendrogenesis and myelination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Altered expression of neuropeptides in the primary somatosensory cortex of the Down syndrome model Ts65Dn.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Increased expression of beta-catenin in brain microvessels of a segmentally trisomic (Ts65Dn) mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Upregulation of beta-catenin expression in down syndrome model Ts65Dn mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Development of interlaminar astroglial processes in the cerebral cortex of control and Down's syndrome human cases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F171639

Dyrk1A influences neuronal morphogenesis through regulation of cytoskeletal dynamics in mammalian cortical neurons.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Astroglia disturbances during development of the central nervous system in fetuses with Down's syndrome.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Gait analysis and cerebral volumes in Down's syndrome.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Elevated expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in cerebellar unipolar brush cells of a Down syndrome mouse model

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

MRI volumes of the hippocampus and amygdala in adults with Down's syndrome with and without dementia

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

A tumor profile in Down syndrome.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403492

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22848846

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A lack of neuroblastoma in Down syndrome: a study from 11 European countries

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22848846

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Differential effects of trisomy on brain shape and volume in related aneuploid mouse models

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22848846

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1155/2012/171639

1 reference

12 August 2017

1 reference

PMC publication ID

3403492

12 August 2017

PubMed publication ID

22848846

1 reference

PMC publication ID

3403492