(Q36112435)

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Early intervention with a small molecule inhibitor for tumor necrosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease

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scholarly article

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Europe PubMed Central

PMC publication ID

12 August 2017

Early intervention with a small molecule inhibitor for tumor necrosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease (English)

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Alzheimer's disease

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author name string

S Prasad Gabbita

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Minu K Srivastava

2

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Europe PubMed Central

PMC publication ID

12 August 2017

Pirooz Eslami

3

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Ming F Johnson

4

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Naomi K Kobritz

5

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

David Tweedie

6

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Nigel H Greig

7

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Frank P Zemlan

8

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Sherven P Sharma

9

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Marni E Harris-White

10

1 reference

Europe PubMed Central

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12 August 2017

language of work or name

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25 May 2012

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12 August 2017

Journal of Neuroinflammation

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Europe PubMed Central

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12 August 2017

9

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

99

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

https://scigraph.springernature.com/pub.10.1186/1742-2094-9-99

0 references

Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations

1 reference

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Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

1 reference

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Tumor necrosis factor-α synthesis inhibitor, 3,6'-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice

1 reference

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2 October 2017

Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system

1 reference

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Design, synthesis and biological assessment of novel N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines and 3-substituted 2,6-dioxopiperidines for TNF-α inhibitory activity

1 reference

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Isolation of brain and spinal cord mononuclear cells using percoll gradients

1 reference

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TNF-α contributes to caspase-3 independent apoptosis in neuroblastoma cells: role of NFAT

1 reference

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CCR6: a biomarker for Alzheimer's-like disease in a triple transgenic mouse model

1 reference

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2 October 2017

Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors

1 reference

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Exploring the full spectrum of macrophage activation

1 reference

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2 October 2017

Tumor necrosis factor-alpha potentiates intraneuronal Ca2+ signaling via regulation of the inositol 1,4,5-trisphosphate receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

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Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

1 reference

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2 October 2017

Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

1 reference

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Innate recognition of viruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Microglial senescence: does the brain's immune system have an expiration date?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Discovery of neurogenic, Alzheimer's disease therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Clinical aspects of inflammation in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Neuroinflammation: a potential therapeutic target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Validation of the neuroinflammation cycle as a drug discovery target using integrative chemical biology and lead compound development with an Alzheimer's disease-related mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Pharmacotherapeutic approaches to the prevention of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Microglia and neuroinflammation: a pathological perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Microglia and Alzheimer's disease pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Macrophage-derived tumor necrosis factor alpha, an early developmental signal for motoneuron death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Thiothalidomides: Novel Isosteric Analogues of Thalidomide with Enhanced TNF-α Inhibitory Activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Intrathecal inflammation precedes development of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Inflammatory processes in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Thalidomide: current therapeutic uses and management of its toxicities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

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Control of synaptic strength by glial TNFalpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

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beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

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Synaptic plasticity in hippocampal CA1 neurons of mice lacking type 1 inositol-1,4,5-trisphosphate receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Inflammation and Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

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HIV-1 infection induces differentiation of immature neural cells through autocrine tumor necrosis factor and nitric oxide production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

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Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

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Involvement of interleukin-1 and lipocortin-1 in ischaemic brain damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

An endotoxin-induced serum factor that causes necrosis of tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 October 2017

Tumor necrosis factor-α signaling maintains the ability of cortical synapses to express synaptic scaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 July 2018

Tumor necrosis factor-alpha modulates survival, proliferation, and neuronal differentiation in neonatal subventricular zone cell cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 July 2018

Glial-neuronal interactions in Alzheimer's disease: the potential role of a 'cytokine cycle' in disease progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 July 2018

Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 July 2018

Translational blockade imposed by cytokine-derived UA-rich sequences.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 July 2018

In vivo relationship of tumor necrosis factor-alpha to blood-brain barrier damage in patients with active multiple sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

2 July 2018

Tumour necrosis factor-alpha impairs neuronal differentiation but not proliferation of hippocampal neural precursor cells: Role of Hes1.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Intracerebral production of tumor necrosis factor-alpha, a local neuroprotective agent, in Alzheimer disease and vascular dementia.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Connecting TNF-alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid beta protein.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Amyloid deposition and inflammation in APPswe/PS1dE9 mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Identification of CD40 ligand in Alzheimer's disease and in animal models of Alzheimer's disease and brain injury

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Decreased behavioral impairments in an Alzheimer mice model by interfering with TNF-alpha metabolism.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Restraining tumor necrosis factor-alpha by thalidomide prevents the amyloid beta-induced impairment of recognition memory in mice

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Genomic and proteomic microglial profiling: pathways for neuroprotective inflammatory responses following nerve fragment clearance and activation.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

The blood-central nervous system barriers actively control immune cell entry into the central nervous system.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Minocycline reduces engraftment and activation of bone marrow-derived cells but sustains their phagocytic activity in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Chronic amphetamine treatment reduces NGF and BDNF in the rat brain.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-99

21 January 2018

Thalidomide-based TNF-alpha inhibitors for neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

23 September 2018

Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403851

23 September 2018

Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/22632257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/22632257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1742-2094-9-99

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

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0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

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