(Q36119968)

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Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase.

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17880684%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase (English)

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17880684%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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7 January 2020

Jau-Shyong Hong

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7 January 2020

author name string

Li Qian

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7 January 2020

Wei Zhang

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7 January 2020

Belinda Wilson

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7 January 2020

Patrick M Flood

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7 January 2020

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19 September 2007

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7 January 2020

full work available at URL

https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-4-23

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19 March 2024

https://api.unpaywall.org/v2/10.1186/1742-2094-4-23?email=unpaywall_01@example.com

Journal of Neuroinflammation

1 reference

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7 January 2020

4

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7 January 2020

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7 January 2020

online access status

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19 March 2024

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https://scigraph.springernature.com/pub.10.1186/1742-2094-4-23

0 references

Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

2 October 2017

MPTP and SNpc DA neuronal vulnerability: role of dopamine, superoxide and nitric oxide in neurotoxicity. Minireview

1 reference

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2 October 2017

Activation and assembly of the NADPH oxidase: a structural perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

2 October 2017

Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma

1 reference

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2 October 2017

NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

1 reference

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2 October 2017

Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention.

1 reference

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2 October 2017

Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease

1 reference

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2 October 2017

Inhibition by naloxone stereoisomers of beta-amyloid peptide (1-42)-induced superoxide production in microglia and degeneration of cortical and mesencephalic neurons

1 reference

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2 October 2017

Characterization of a novel brain-derived microglial cell line isolated from neonatal rat brain

1 reference

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2 October 2017

Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

2 October 2017

Microglia: a sensor for pathological events in the CNS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

2 October 2017

Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

2 October 2017

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1 reference

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2 October 2017

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

2 October 2017

Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

2 October 2017

Neuroinflammation alters the hippocampal pattern of behaviorally induced Arc expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

2 July 2018

Immunomodulatory effects of the alkaloid sinomenine in the high responder ACI-to-Lewis cardiac allograft model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

2 July 2018

Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP4-6 are neuroprotective through inhibition of NADPH oxidase: potent regulators of microglia-mediated oxidative stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

23 September 2018

Interleukin-10 protects lipopolysaccharide-induced neurotoxicity in primary midbrain cultures by inhibiting the function of NADPH oxidase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

23 September 2018

Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

23 September 2018

Effect of sinomenine on cytokine expression of macrophages and synoviocytes in adjuvant arthritis rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

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23 September 2018

The effect of sinomenine on cyclooxygenase activity and the expression of COX-1 and COX-2 mRNA in human peripheral monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

23 September 2018

NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

23 September 2018

Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

23 September 2018

Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

23 September 2018

Study progress in Sinomenium acutum (Thunb.) Rehd. et Wils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064906

23 September 2018

Soman-induced seizures: limbic activity, oxidative stress and neuroprotective proteins

1 reference

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23 September 2018

Role of intracellular thiol depletion, mitochondrial dysfunction and reactive oxygen species in Salvia miltiorrhiza-induced apoptosis in human hepatoma HepG2 cells

1 reference

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23 September 2018

Tumor necrosis factor alpha is toxic to embryonic mesencephalic dopamine neurons

1 reference

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23 September 2018

Activation of p47(PHOX), a cytosolic subunit of the leukocyte NADPH oxidase. Phosphorylation of ser-359 or ser-370 precedes phosphorylation at other sites and is required for activity.

1 reference

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23 September 2018

A microtiter plate assay for superoxide dismutase using a water-soluble tetrazolium salt (WST-1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17880684

12 December 2020

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inferred from PubMed ID database lookup

Superoxide produced by activated neutrophils efficiently reduces the tetrazolium salt, WST-1 to produce a soluble formazan: a simple colorimetric assay for measuring respiratory burst activation and for screening anti-inflammatory agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/17880684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction by naloxone of lipopolysaccharide-induced neurotoxicity in mouse cortical neuron–glia co-cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/17880684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17880684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacology of sinomenine. VII. Effect of sinomenine on the gastro-intestinal movement and its mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17880684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of beta endorphin on specific immune responses in man

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Respiratory burst inhibition in human neutrophils by ultra-low doses of [D-Ala2 ]methionine enkephalinamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17880684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection by sinomenine against endotoxin-induced fulminant hepatitis in galactosamine-sensitized mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17880684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of rat experimental arthritides by treatment with the alkaloid sinomenine

1 reference

https://pubmed.ncbi.nlm.nih.gov/17880684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic effects of the alkaloid sinomenine in combination with the immunosuppressive drugs tacrolimus and mycophenolic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/17880684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1742-2094-4-23

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Europe PubMed Central

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7 January 2020

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7 January 2020

1 reference

Europe PubMed Central

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7 January 2020

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