(Q36122184)

English

Phosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates endoplasmic reticulum (ER) stress-induced insulin resistance in hepatocytes

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Phosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates endoplasmic reticulum (ER) stress-induced insulin resistance in hepatocytes (English)

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

endoplasmic reticulum

0 references

insulin resistance

1 reference

based on heuristic

inferred from title

Ricardo Villarreal

4

object named as

Ricardo Villarreal

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

author name string

Meilian Liu

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Lijun Zhou

2

1 reference

Europe PubMed Central

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12 August 2017

Li Wei

3

1 reference

Europe PubMed Central

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12 August 2017

Xin Yang

5

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Derong Hu

6

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Ramon A Riojas

7

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Bekke M Holmes

8

1 reference

Europe PubMed Central

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12 August 2017

Paul R Langlais

9

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Hakjoo Lee

10

1 reference

Europe PubMed Central

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12 August 2017

Lily Q Dong

11

1 reference

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12 August 2017

language of work or name

0 references

publication date

8 June 2012

1 reference

Europe PubMed Central

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12 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

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12 August 2017

287

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

31

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

26087-26093

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

APPL1 mediates adiponectin-stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

Adiponectin receptor binding proteins--recent advances in elucidating adiponectin signalling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

DsbA-L alleviates endoplasmic reticulum stress-induced adiponectin downregulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

Identification of phosphorylation sites within the signaling adaptor APPL1 by mass spectrometry.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

Differential effects of tumor necrosis factor-alpha on protein kinase C isoforms alpha and delta mediate inhibition of insulin receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 October 2017

Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 July 2018

Mediation by arachidonic acid metabolites of the H2O2-induced stimulation of mitogen-activated protein kinases (extracellular-signal-regulated kinase and c-Jun NH2-terminal kinase).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3406692

2 July 2018

Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.372292

21 January 2018

The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.372292

21 January 2018

APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.372292

21 January 2018

Involvement of endoplasmic reticulum stress in insulin resistance and diabetes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.372292

21 January 2018

Rosiglitazone, insulin treatment, and fasting correct defective activation of protein kinase C-zeta/lambda by insulin in vastus lateralis muscles and adipocytes of diabetic rats

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.372292

21 January 2018

Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22685300

12 December 2020

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Identifiers

10.1074/JBC.M112.372292

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

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