(Q36124533)

12 August 2017

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title

Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function (English)

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12 August 2017

Hanne L Ostergaard

1

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12 August 2017

Tara L Lysechko

series ordinal

2

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12 August 2017

1 January 2005

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12 August 2017

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12 August 2017

31

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12 August 2017

267-282

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12 August 2017

3

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https://scigraph.springernature.com/pub.10.1385/ir:31:3:267

12 August 2017

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cites work

Phosphoinositide 3-kinase: a key biochemical signal for cell migration in response to chemokines.

1 reference

12 December 2020

The interaction of activated integrin lymphocyte function-associated antigen 1 with ligand intercellular adhesion molecule 1 induces activation and redistribution of focal adhesion kinase and proline-rich tyrosine kinase 2 in T lymphocytes.

1 reference

12 December 2020

A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal

1 reference

12 December 2020

RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner

1 reference

12 December 2020

Inhibition of the calcium-dependent tyrosine kinase (CADTK) blocks monocyte spreading and motility

1 reference

12 December 2020

MIP-1alpha induces activation of phosphatidylinositol-3 kinase that associates with Pyk-2 and is necessary for B-cell migration

1 reference

12 December 2020

Inhibition of the catalytic activity of cell adhesion kinase beta by protein-tyrosine phosphatase-PEST-mediated dephosphorylation

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12 December 2020

RAFTK/Pyk2-mediated cellular signalling

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12 December 2020

Molecular cloning and assignment of FAK2, a novel human focal adhesion kinase, to 8p11.2-p22 by nonisotopic in situ hybridization.

1 reference

12 December 2020

The beta1 and beta3 integrins promote T cell receptor-mediated cytotoxic T lymphocyte activation

1 reference

12 December 2020

A p56lck-independent Pathway of CD2 Signaling Involves Jun Kinase

1 reference

12 December 2020

Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization

1 reference

12 December 2020

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12 December 2020

CD28 ligation induces tyrosine phosphorylation of Pyk2 but not Fak in Jurkat T cells

1 reference

12 December 2020

Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation

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12 December 2020

LFA-1 integrin and the microtubular cytoskeleton are involved in the Ca(2)(+)-mediated regulation of the activity of the tyrosine kinase PYK2 in T cells

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12 December 2020

Alpha 4 beta 1 integrin-mediated tyrosine phosphorylation in human T cells: characterization of Crk- and Fyn-associated substrates (pp105, pp115, and human enhancer of filamentation-1) and integrin-dependent activation of p59fyn1.

1 reference

12 December 2020

Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily

1 reference

12 December 2020

Beta 1/beta 3 integrin ligation is uncoupled from ERK1/ERK2 activation in cytotoxic T lymphocytes

1 reference

12 December 2020

Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation

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12 December 2020

Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling

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12 December 2020

The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes

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12 December 2020

Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin

1 reference

12 December 2020

Cutting edge: functional role for proline-rich tyrosine kinase 2 in NK cell-mediated natural cytotoxicity

1 reference

12 December 2020

Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein

1 reference

12 December 2020

A physical interaction between the cell death protein Fas and the tyrosine kinase p59fynT.

1 reference

12 December 2020

Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism

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12 December 2020

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

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12 December 2020

Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling

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12 December 2020

A function for the AP3 coat complex in synaptic vesicle formation from endosomes

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12 December 2020

Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402

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12 December 2020

FERM domain interaction promotes FAK signaling

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12 December 2020

TCR engagement induces proline-rich tyrosine kinase-2 (Pyk2) translocation to the T cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion

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12 December 2020

Paxillin phosphorylation and association with Lck and Pyk2 in anti-CD3- or anti-CD45-stimulated T cells

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12 December 2020

Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain

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12 December 2020

Pyk2 is differentially regulated by beta1 integrin- and CD28-mediated co-stimulation in human CD4+ T lymphocytes

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12 December 2020

Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5.

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12 December 2020

Cytotoxic T lymphocytes express a beta3 integrin which can induce the phosphorylation of focal adhesion kinase and the related PYK-2

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12 December 2020

Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk

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12 December 2020

Regulation of Pyk2 expression by p56(Lck) in Jurkat T lymphocytes.

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12 December 2020

Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein.

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12 December 2020

PYK2 autophosphorylation, but not kinase activity, is necessary for adhesion-induced association with c-Src, osteoclast spreading, and bone resorption

1 reference

12 December 2020

Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration

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12 December 2020

Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton

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12 December 2020

A critical role for p59fyn in CD2-based signal transduction

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12 December 2020

The tyrosine kinase PYK-2/RAFTK regulates natural killer (NK) cell cytotoxic response, and is translocated and activated upon specific target cell recognition and killing

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12 December 2020

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

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12 December 2020

Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways

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12 December 2020

The N-termini of FAK and JAKs contain divergent band 4.1 domains

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12 December 2020

Identification of a new Pyk2 isoform implicated in chemokine and antigen receptor signaling.

1 reference

12 December 2020

Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins

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12 December 2020

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

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12 December 2020

Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway

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12 December 2020

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

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12 December 2020

Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration

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12 December 2020

Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction

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12 December 2020

RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes

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12 December 2020

Interaction of two proline-rich sequences of cell adhesion kinase beta with SH3 domains of p130Cas-related proteins and a GTPase-activating protein, Graf

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12 December 2020

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

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12 December 2020

Identification of a new Pyk2 target protein with Arf-GAP activity

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12 December 2020

Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response

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12 December 2020

Cell migration: integrating signals from front to back

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12 December 2020

Sustained TCR signaling is required for mitogen-activated protein kinase activation and degranulation by cytotoxic T lymphocytes

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12 December 2020

Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42

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12 December 2020

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

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12 December 2020

Rho and Rho-associated kinase modulate the tyrosine kinase PYK2 in T-cells through regulation of the activity of the integrin LFA-1.

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12 December 2020

Role of the cytoskeleton during leukocyte responses

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12 December 2020

T cell receptor engagement induces tyrosine phosphorylation of FAK and Pyk2 and their association with Lck.

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12 December 2020

CD44-initiated cell spreading induces Pyk2 phosphorylation, is mediated by Src family kinases, and is negatively regulated by CD45.

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12 December 2020

ARF: a key regulatory switch in membrane traffic and organelle structure

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12 December 2020

Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases

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12 December 2020

Identifiers

DOI

10.1385/IR:31:3:267

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Dimensions Publication ID

12 August 2017

1034890143

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Fatcat ID

release_gcsjfgweinbyljpxdjsygwc7gu

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/gcsjfgweinbyljpxdjsygwc7gu

24 November 2022

mapped directly with Wikidata item

1 reference