(Q36138014)

12 August 2017

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title

Roles of a trithorax group gene, MLL, in hematopoiesis (English)

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12 August 2017

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Ryoichi Ono

1

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12 August 2017

Tetsuya Nosaka

series ordinal

2

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12 August 2017

Yasuhide Hayashi

series ordinal

3

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12 August 2017

1 May 2005

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International Journal of Hematology

12 August 2017

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12 August 2017

81

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12 August 2017

4

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12 August 2017

288-293

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https://scigraph.springernature.com/pub.10.1532/ijh97.04196

12 August 2017

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cites work

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties

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12 December 2020

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

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12 December 2020

FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23).

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12 December 2020

Chromatin silencing and activation by Polycomb and trithorax group proteins

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12 December 2020

Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins

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12 December 2020

Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias

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12 December 2020

MLL: a histone methyltransferase disrupted in leukemia

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12 December 2020

LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23).

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12 December 2020

The critical role of chromosome translocations in human leukemias.

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12 December 2020

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

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12 December 2020

Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis

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12 December 2020

Definitive hematopoiesis requires the mixed-lineage leukemia gene

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12 December 2020

Isolation and characterization of a pufferfish MLL (mixed lineage leukemia)-like gene (fMll) reveals evolutionary conservation in vertebrate genes related to Drosophila trithorax

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12 December 2020

Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis

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12 December 2020

Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro

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12 December 2020

Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells

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12 December 2020

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

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12 December 2020

SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24

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12 December 2020

The role of the MLL gene in infant leukemia

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12 December 2020

COMPASS: a complex of proteins associated with a trithorax-related SET domain protein

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12 December 2020

Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites

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12 December 2020

Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression

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12 December 2020

MLL targets SET domain methyltransferase activity to Hox gene promoters

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12 December 2020

Oncogenic transcription factors in the human acute leukemias

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12 December 2020

Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin

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12 December 2020

Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice

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12 December 2020

ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation

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12 December 2020

A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3

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12 December 2020

The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene

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12 December 2020

The molecular genetics of recurring chromosome abnormalities in acute myeloid leukemia

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12 December 2020

The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex

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12 December 2020

AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)

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12 December 2020

The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation

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12 December 2020

AF17q25, a putative septin family gene, fuses the MLL gene in acute myeloid leukemia with t(11;17)(q23;q25)

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12 December 2020

Frequency and clinical significance of the MLL gene rearrangements in infant acute leukemia

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12 December 2020

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

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12 December 2020

ASH1, a Drosophila trithorax group protein, is required for methylation of lysine 4 residues on histone H3

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12 December 2020

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

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12 December 2020

Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer

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12 December 2020

t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes

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12 December 2020

Dimerization of MLL fusion proteins immortalizes hematopoietic cells

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12 December 2020

An Mll-dependent Hox program drives hematopoietic progenitor expansion

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12 December 2020

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

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12 December 2020

MLL/SEPTIN6 chimeric transcript from inv ins(X;11)(q24;q23q13) in acute monocytic leukemia: report of a case and review of the literature

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12 December 2020

Histone methyltransferase activity of a Drosophila Polycomb group repressor complex

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12 December 2020

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene

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12 December 2020

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

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12 December 2020

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

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12 December 2020

Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development

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12 December 2020

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

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12 December 2020

Truncation of the Mll gene in exon 5 by gene targeting leads to early preimplantation lethality of homozygous embryos.

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12 December 2020

An ins(X;11)(q24;q23) fuses the MLL and the Septin 6/KIAA0128 gene in an infant with AML-M2.

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12 December 2020

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

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12 December 2020

MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

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12 December 2020

The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX.

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12 December 2020

An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

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12 December 2020

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

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12 December 2020

Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells

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12 December 2020

The small oligomerization domain of gephyrin converts MLL to an oncogene

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12 December 2020

Defects in yolk sac hematopoiesis in Mll-null embryos.

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12 December 2020

Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23)

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12 December 2020

Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex

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12 December 2020

MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis

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12 December 2020

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1

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12 December 2020

Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13).

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12 December 2020

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

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12 December 2020

MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)

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12 December 2020

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).

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12 December 2020

Altered Hox expression and segmental identity in Mll-mutant mice

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12 December 2020

The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4

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12 December 2020

Molecular analysis of t(X;11)(q24;q23) in an infant with AML‐M4

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12 December 2020

Gene expression profiling in childhood acute leukemia: progress and perspectives

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12 December 2020

Origins of chromosome translocations in childhood leukaemia

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12 December 2020

MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisom

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12 December 2020

The hare and the tortoise: an embryonic haematopoietic race.

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12 December 2020

Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein

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12 December 2020

The role of MLL in hematopoiesis and leukemia

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12 December 2020

Identifiers

DOI

10.1532/IJH97.04196

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Dimensions Publication ID

12 August 2017

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