(Q36145591)

12 August 2017

Programmed disorders of beta-cell development and function as one cause for type 2 diabetes? The GK rat paradigm (English)

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12 August 2017

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Bernard Portha

1

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12 August 2017

1 November 2005

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Diabetes - Metabolism: Research and Reviews

12 August 2017

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12 August 2017

21

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12 August 2017

6

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12 August 2017

495-504

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

12 August 2017

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7 January 2021

Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea

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7 January 2021

Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects

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7 January 2021

Hyperglycemic crises in patients with diabetes mellitus

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7 January 2021

Diabetes mellitus and genetically programmed defects in beta-cell function

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7 January 2021

Maturity-onset diabetes of the young: a clinical history

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7 January 2021

Maternally inherited diabetes and deafness: a new diabetes subtype

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7 January 2021

Mitochondrial function in normal and diabetic beta-cells

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7 January 2021

Diabetes in identical twins. A study of 200 pairs

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7 January 2021

Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins

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7 January 2021

Searching for type 2 diabetes genes in the post-genome era.

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7 January 2021

Genetic approaches to the molecular understanding of type 2 diabetes

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7 January 2021

Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis

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7 January 2021

beta-cell function and viability in the spontaneously diabetic GK rat: information from the GK/Par colony

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7 January 2021

Beta-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes

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7 January 2021

Defective glucose-dependent cytosolic Ca2+ handling in islets of GK and nSTZ rat models of type 2 diabetes

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7 January 2021

Impaired development of pancreatic beta-cell mass is a primary event during the progression to diabetes in the GK rat.

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7 January 2021

Decreased pancreatic islet response to L-leucine in the spontaneously diabetic GK rat: enzymatic, metabolic and secretory data

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7 January 2021

Beta-cell growth in the neonatal Goto-Kakisaki rat and regeneration after treatment with streptozotocin at birth

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7 January 2021

Impaired pancreatic beta cell function in the fetal GK rat. Impact of diabetic inheritance

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7 January 2021

Early development of beta-cells is impaired in the GK rat model of type 2 diabetes

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7 January 2021

Impaired beta-cell regeneration after partial pancreatectomy in the adult Goto-Kakizaki rat, a spontaneous model of type II diabetes

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7 January 2021

Impaired pancreatic duct-cell growth in focal areas of regeneration after partial pancreatectomy in the adult Goto-Kakizaki rat, a spontaneous model of non-insulin dependent diabetes mellitus

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7 January 2021

Hyperglycemia contributes to impaired insulin response in GK rat islets

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7 January 2021

Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment

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7 January 2021

Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats

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7 January 2021

Metabolic programming: causes and consequences

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7 January 2021

For debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure.

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7 January 2021

The endocrine pancreas of the fetus from diabetic pregnant rat

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7 January 2021

Diabetes in pregnancy: effects on the foetal and newborn rat with particular regard to body weight, serum insulin concentration and pancreatic contents of insulin, glucagon and somatostatin

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7 January 2021

Maternal diabetes during pregnancy: consequences for the offspring.

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7 January 2021

Gestational diabetes leads to the development of diabetes in adulthood in the rat.

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7 January 2021

Impaired glucose homeostasis in adult rats from hyperglycemic mothers

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7 January 2021

Inheritance of diabetes mellitus as consequence of gestational hyperglycemia in rats

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7 January 2021

Effect of a low protein diet during pregnancy on the fetal rat endocrine pancreas

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7 January 2021

Age-dependent inability of the endocrine pancreas to adapt to pregnancy: a long-term consequence of perinatal malnutrition in the rat

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7 January 2021

Zinc depletion reduced Egr-1 and HNF-3beta expression and apolipoprotein A-I promoter activity in Hep G2 cells

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7 January 2021

Disturbed development of the preimplantation embryo in the insulin-dependent diabetic BB/E rat.

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7 January 2021

Type 2 diabetes mellitus--genes or intrauterine environment? An embryo transfer paradigm in rats.

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7 January 2021

Genomic imprinting and epigenetic reprogramming: unearthing the garden of forking paths

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7 January 2021

Folate, DNA methylation, and gene expression: factors of nature and nurture

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7 January 2021

Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat

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7 January 2021

Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat.

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7 January 2021

Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (Type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8.

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7 January 2021

Pathophysiological and genetic characterization of the major diabetes locus in GK rats

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7 January 2021

Phenotyping of individual pancreatic islets locates genetic defects in stimulus secretion coupling to Niddm1i within the major diabetes locus in GK rats

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7 January 2021

Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of AC-III mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type 2 diabetes

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7 January 2021

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats

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7 January 2021

The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man

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7 January 2021

Identifiers

DOI

10.1002/DMRR.566

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12 August 2017

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PubMed ID

15926190